Extraocular muscle afferents to the cerebellum of the cat

Fuchs, Albert F.; Kornhuber, H. H.

doi:10.1113/jphysiol.1969.sp008718

Cited by 154 publications

(26 citation statements)

References 19 publications

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“…The first is related to the proprioceptive impulses from stretch receptors in the extraocular muscles. There is considerable evidence that there are stretch receptors in the extraocular muscles which generate inflow signals to the cerebellum (Fuchs & Kornhuber, 1969;Baker, Precht & Llina's, 1972). Recently, Maekawa & Kimura (1980) showed that such signals reach the flocculus in the rabbit.…”

Section: Discussionmentioning

confidence: 99%

Eye position signals in the flocculus of the monkey during smooth‐pursuit eye movements

Noda

Warabi

1982

The Journal of Physiology

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SUMMARY1. Discharges of Purkinje cells and mossy fibres were recorded from the flocculus of monkeys trained to fixate a small visual target and to track the target when it moved slowly.2. Discharges of Purkinje cells changed tonically with shifts of gaze. Firing rates were linearly related to eye positions for either the entire or more than half the eye-position range in 12-6 % of Purkinje cells tested (76/603 units).3. The eye position-related activity (position component) was observable in these cells also during smooth-pursuit eye movements. It was typically seen during slow eye movements (velocities less than 10 deg/s) but became undetectable during high velocity movements (faster than 50 deg/s).4. The position component became prominent when smooth pursuit was executed at the preferred loci of the individual cells. In the majority of the cells tested at their preferred loci, the position component was observable to a relatively high frequency, such as 0-5 Hz (± 10 deg; peak velocity 31 deg/s).5. Forty-five mossy fibre units showed saccade-related bursts and position-related intersaccadic tonic activity during steady eye position. In each unit, the position component was found only during fixations within a specific range of eye positions. During fixations outside these regions, all position-related mossy fibres were completely silent.6. During sinusoidal smooth-pursuit eye movements, the mossy fibres also displayed cyclic modulations in activity. All fibres discharged with eye movements in one direction and were silent during eye movements in the other direction.7. Saccade-related bursts from mossy fibres led the onset of saccades, ranging from 0 to 19 ms with a mean lead-time of 6-9 ms. This observation negates the possibility that the position-related signals might represent proprioceptive impulses from the stretch receptors of the extraocular muscle.

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Section: Discussionmentioning

confidence: 99%

Eye position signals in the flocculus of the monkey during smooth‐pursuit eye movements

Noda

Warabi

1982

The Journal of Physiology

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“…The effect of artificial spindle stimulation on perception of limb orientation is easily demonstrated in humans by the ability of an externally imposed vibration over a muscle to produce the perception of muscle shortening (65). Supporting physiological evidence comes from the discovery of cortical representations of certain muscle spindle afferents (59). Specific application of vibration to certain postural muscles can produce predictable changes in body orientation.…”

Section: Limb Positionmentioning

confidence: 99%

Perception of the Body in Space: Mechanisms

Young

1984

Comprehensive Physiology

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“…The motor representation in lobule V/VI of the ipsilateral cerebellum receives an efference copy of the motor command, sent out from cortical motor areas (Ebner and Pasalar, 2008). This efference copy, together with the proprioceptive feedback from the ongoing movements (Fuchs and Kornhuber, 1969;Bloedel and Courville, 1981), and the somatosensory information from the cortex are used to calculate a current somatosensory state estimate and to predict the sensory consequences of the motor behavior. The lobules V and VI transmit the information to the ipsilateral dorsal dentate nucleus, which itself also receives cerebral input via the pontine nuclei (Shinoda et al, 1992).…”

Section: Corticocerebellar Networkmentioning

confidence: 99%

An Intact Action-Perception Coupling Depends on the Integrity of the Cerebellum

et al. 2014

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It is widely accepted that action and perception in humans functionally interact on multiple levels. Moreover, areas originally suggested to be predominantly motor-related, as the cerebellum, are also involved in action observation. However, as yet, few studies provided unequivocal evidence that the cerebellum is involved in the action perception coupling (APC), specifically in the integration of motor and multisensory information for perception. We addressed this question studying patients with focal cerebellar lesions in a virtual-reality paradigm measuring the effect of action execution on action perception presenting self-generated movements as point lights. We measured the visual sensitivity to the point light stimuli based on signal detection theory. Compared with healthy controls cerebellar patients showed no beneficial influence of action execution on perception indicating deficits in APC. Applying lesion symptom mapping, we identified distinct areas in the dentate nucleus and the lateral cerebellum of both hemispheres that are causally involved in APC. Lesions of the right ventral dentate, the ipsilateral motor representations (lobules V/VI), and most interestingly the contralateral posterior cerebellum (lobule VII) impede the benefits of motor execution on perception. We conclude that the cerebellum establishes timedependent multisensory representations on different levels, relevant for motor control as well as supporting action perception. Ipsilateral cerebellar motor representations are thought to support the somatosensory state estimate of ongoing movements, whereas the ventral dentate and the contralateral posterior cerebellum likely support sensorimotor integration in the cerebellar-parietal loops. Both the correct somatosensory as well as the multisensory state representations are vital for an intact APC.

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Extraocular muscle afferents to the cerebellum of the cat

Cited by 154 publications

References 19 publications

Eye position signals in the flocculus of the monkey during smooth‐pursuit eye movements

Eye position signals in the flocculus of the monkey during smooth‐pursuit eye movements

Perception of the Body in Space: Mechanisms

An Intact Action-Perception Coupling Depends on the Integrity of the Cerebellum

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