Extraoral bitter taste receptors in health and disease

Lü, Ping; Zhang, Cheng–Hai; Lifshitz, Lawrence M.

doi:10.1085/jgp.201611637

Cited by 182 publications

(196 citation statements)

References 149 publications

Supporting

Mentioning

190

Contrasting

Unclassified

Order By: Relevance

“…В последнее время было установлено, что, кроме признанных PRR, в защите респираторного тракта от инфекционных патогенов участвуют рецепторы традиционных сенсорных путей трансдукции сиг-нала, а именно представители двух семейств хемо-сенсорных вкусовых рецепторов (taste receptor) -TAS1R, TAS2R (табл. 1) [50,73].…”

Section: Staphylococcus Aureus эпителиоцитыunclassified

Розвиток Імунної Відповіді При Стафілококовій Пневмонії (Частина 5)

Абатуров

Никулина

2021

View full text Add to dashboard Cite

У статті на підставі літературних джерел продемонстрована роль клітинних реакцій у розвитку імунної відповіді при пневмонії, спричиненої Staphylococcus aureus. Описані механізми взаємодії Staphylococcus aureus з образ-розпізнавальними рецепторами епітеліоцитів респіраторного тракту, такими як хемосенсорні смакові рецептори, рекрутування та активації макрофагів, що забезпечують ефективний саногенез від стафілококової інфекції. Показані імуномодулююча роль ефероцитозу й основні варіанти клітинної загибелі, що регулюють запалення.

show abstract

Section: Staphylococcus Aureus эпителиоцитыunclassified

Розвиток Імунної Відповіді При Стафілококовій Пневмонії (Частина 5)

Абатуров

Никулина

2021

View full text Add to dashboard Cite

show abstract

“…The chemosensory cells send signals to the nervous system, so that the breathing rate is decreased. In this way, we breathe less bacteria in [3].…”

Section: What Are These Green Fluorescent Cells?mentioning

confidence: 99%

Can a Bitter Taste be Detected Outside the Tongue?

Liu¹,

Atzberger²

2018

Front. Young Minds

View full text Add to dashboard Cite

Bitter, sweet, sour, salty, and savory tastes can be sensed by the tongue through their related taste receptors. The taste of bitter is very important in nature. It protects us from eating harmful things, which usually taste bitter. In this research, we looked for cells that have bitter taste receptors. To make them visible, we labeled them with a green fluorescent protein. These green cells were found on the tongue, as expected, but they were also found in other places that are easily exposed to harmful things, such as the airway, the gut, and the urethra. Our work also showed that the cells expressing bitter receptors could have the ability to activate the immune system. We cannot actually taste bitter anywhere apart from the tongue, but bitter taste receptors in other parts of the body may function in a different way. HOW CAN WE SENSE DIFFERENT TASTES?When food enters the mouth, small molecules of the food can be sensed by the tongue. We know that different foods have different tastes. We can sense five different tastes-sweet, bitter, sour, salty, and savory. We taste these five

show abstract

“…Knockout mouse studies are recommended to support the causal relationship and scientists expect that these will facilitate our understanding on the functional roles of extraoral taste receptors [269]. …”

Section: Limitations Of the Present Hypothesis On Extraoral Tastementioning

confidence: 99%

Extraoral Taste Receptor Discovery: New Light on Ayurvedic Pharmacology

Gîlcă

Dragoș

2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

More and more research studies are revealing unexpectedly important roles of taste for health and pathogenesis of various diseases. Only recently it has been shown that taste receptors have many extraoral locations (e.g., stomach, intestines, liver, pancreas, respiratory system, heart, brain, kidney, urinary bladder, pancreas, adipose tissue, testis, and ovary), being part of a large diffuse chemosensory system. The functional implications of these taste receptors widely dispersed in various organs or tissues shed a new light on several concepts used in ayurvedic pharmacology (dravyaguna vijnana), such as taste (rasa), postdigestive effect (vipaka), qualities (guna), and energetic nature (virya). This review summarizes the significance of extraoral taste receptors and transient receptor potential (TRP) channels for ayurvedic pharmacology, as well as the biological activities of various types of phytochemical tastants from an ayurvedic perspective. The relative importance of taste (rasa), postdigestive effect (vipaka), and energetic nature (virya) as ethnopharmacological descriptors within Ayurveda boundaries will also be discussed.

show abstract

Extraoral bitter taste receptors in health and disease

Cited by 182 publications

References 149 publications

Розвиток Імунної Відповіді При Стафілококовій Пневмонії (Частина 5)

Розвиток Імунної Відповіді При Стафілококовій Пневмонії (Частина 5)

Can a Bitter Taste be Detected Outside the Tongue?

Extraoral Taste Receptor Discovery: New Light on Ayurvedic Pharmacology

Contact Info

Product

Resources

About