Extraorbital Sebaceous Carcinoma With Rapidly Developing Visceral Metastases

Duman, Deniz; Ceyhan, Berrin; Celikel, Turgay; Ahıskalı, Rengin; Duman, Dursun

doi:10.1046/j.1524-4725.2003.29268.x

Cited by 25 publications

(18 citation statements)

References 11 publications

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“…[10] Distant metastases have been reported in <10% of all EOSC cases, which may occur in the abdomen lung, brain, bone, and subcutaneous soft tissue. [10]…”

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confidence: 99%

The usefulness of dermoscopy in extraocular sebaceous carcinoma

Nair¹,

Patel²,

Gandhi³

2018

Indian J Dermatol

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“…[10] Distant metastases have been reported in <10% of all EOSC cases, which may occur in the abdomen lung, brain, bone, and subcutaneous soft tissue. [10]…”

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confidence: 99%

The usefulness of dermoscopy in extraocular sebaceous carcinoma

Nair¹,

Patel²,

Gandhi³

2018

Indian J Dermatol

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“…19,20 Radiation and topical and systemic therapies also have been suggested as useful in the treatment of sebaceous carcinoma, although experience is limited. 7,[20][21][22][23][24][25] Given the rarity of sebaceous carcinoma and the relatively limited information available in the literature regarding US populations, we initiated an investigation of the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database 26 to study the demographics and clinical outcomes of patients with sebaceous carcinoma. The SEER database is a collection of large, population-based cancer registries that records cases and general demographic and pathologic information.…”

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confidence: 99%

A retrospective review of 1349 cases of sebaceous carcinoma

Dasgupta

Wilson

2008

Cancer

328

294

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BACKGROUD:Sebaceous carcinoma is a rare and aggressive cutaneous carcinoma. It is believed that this malignancy predominates in the periocular region and occurs more frequently in Asian populations and in women. The objective of the current study was to analyze demographic characteristics and outcomes for patients with this malignancy from a large United States‐based population registry.METHODS:An analysis of the National Cancer Institute's Surveillance, Epidemiology, and End Results database from 1973 through 2004 was performed.RESULTS:Of 1349 patients who were identified, 54% were men, 86.2% were white, and 5.5% were of Asian/Pacific Islander ancestry. The median age at diagnosis was 73 years. The most frequent site of disease was the eyelid (38.7%). The population‐matched 5‐ and 10‐year age‐matched relative survival rate was 91.9% (standard error [SE], 1.9%) and 79.2% (SE, 3.7%), respectively. Cause of death was attributable to cancer in 31% of patients. Orbital involvement did not predict for worsened survival compared with nonorbital involvement (5‐year overall survival, 75.2% vs 68%, respectively; P = .66). The overall population‐matched rate of sebaceous carcinoma was highest in whites (2.03 cases per 1000,000; SE, 0.08) versus Asian/Pacific Islanders (1.07 per 1000,000; SE, 0.18; P = .0001) versus blacks (0.48 per 1000,000; SE, 0.11; P < .0001).CONCLUSIONS:The current results support the finding of a predominance of men among patients with sebaceous carcinoma, and no difference was observed in the prognosis for orbital and periorbital involvement. This retrospective analysis also corroborated previous case reports of a higher incidence among patients with advanced age and the highest incidence for sites in the eyelid and skin of the face. The results also established that Asian/Pacific Islander ancestry is not a risk factor for developing sebaceous carcinoma. Cancer 2009. © 2008 American Cancer Society.

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“…Af ter two co ur ses of tre at ment, prog res si on was ob ser ved and che mot he rapy re gi men was chan ged to do ce ta xel as a sing le agent. 11 The re was par ti al res pon se to this tre at ment, which was al so con fir med with PET-CT. Up to now, the re was one mo re ca se re port uti li zing PET-CT in the follow-up of SC. 7 …”

Section: Discussionmentioning

confidence: 87%

Aggressive Extra-Ocular Sebaceous Carcinoma Originating from Lumbar Skin with Disseminated Lymphadenopathies: A PET-CT Evaluation: Case Report

Yaman¹,

Coşkun²,

Güner³

et al. 2010

Turkiye Klinikleri J Med Sci

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ebaceous carcinoma (SC) is a malignant adnexal tumor with variable sites of origin, histological patterns and clinical presentations. Eyelid SC is the most common type of SC and comprises 1-5.5% of all eyelid tumors.1 Extra-orbital SC accounts only 25% of all cases, arising mostly from the head and neck region.2 It typically presents as a slow growing mass and is believed to be an indolent tumor with better prognosis compared to its ocular counterpart 1 , although there are some reports claiming the contrary. 3To our knowledge, this is the first report of SC originating from lumbar region. Moreover, this case is associated with generalized involvement of lymph nodes which is exceedingly rare. A PET-CT Evaluation: Case Report A AB BS S T TR RA AC CT T Se ba ce o us car ci no ma (SC) is a ma lig nant ad ne xal tu mor, usu ally ori gi na ting from eyelids. Ex tra-or bi tal se ba ce o us car ci no ma is a ra re car ci no ma lo ca li zed com monly in he ad and neck re gi on. Alt ho ugh ex tra-or bi tal SC has an in do lent co ur se, it may ha ve highly in va si ve pro per ti es and may ca u se dis tant me tas ta ses ra pidly. We re port a 46 ye ar-old-wo man with ex tra-or bi tal SC ori gina ting from lum bar skin. Just af ter two months from the ex ci si on of pri mary le si on, pa ti ent re admit ted with axil lary lympha de no pat hi es. po sit ron emis si on to mog raphy (PET-CT) was used for eva lu a ti on of both ex tent of di se a se and tre at ment res pon se. Par ti al re mis si on was ob ser ved with do ce ta xel tre at ment. This ca se il lus tra tes how ex tra-ocu lar SC can be ha ve ag gres si vely des pi te the tra di ti o nal be li ef. PET-CT can help to eva lu a te the ex tent of di se a se and res pon se to the rapy.K Ke ey y W Wo or rd ds s: : Se ba ce o us gland ne op lasms; lum bo sac ral re gi on; po sit ron-emis si on to mog raphy Ö ÖZ ZE ET T Se ba se kar si nom, ge nel lik le göz ka pak la rın dan kö ken alan ma lign de ri eki tü mö rü dür. Ekstra-okü ler se ba se kar si nom lar na dir olup, sık lık la baş-bo yun böl ge sin de göz le nir ler. Her ne ka dar ya vaş se yir li ola rak bil di ril se ler de ba zı va ka lar da yük sek bir in va ziv po tan si yel göz le nir ve uzak metas taz sap ta na bi lir. Bu va ka da lom ber de ri den kö ken alan eks tra-okü ler se ba se kar si nom lu 46 ya şın -da bir ka dın has ta tak dim edil di. İlk lez yo nun cer ra hi ola rak çı ka rı mın dan sa de ce iki ay son ra has ta da ak sil ler len fa de no pa ti ler sap tan dı. Po zit ron emis yon to mog ra fi (PET-BT) hem has ta lık yaygın lı ğı nı hem de te da vi ya nı tı nı de ğer len dir mek ama cıy la kul la nıl dı. İkin ci ba sa mak te da vi de kulla nı lan do si tak sel re ji mi ile par si yel ya nıt göz len di. Bu va ka, eks tra-okü ler se ba se kar si no mun za man za man na sıl bir ag re sif se yir iz le ye bi le ce ği ni gös ter mek te dir. PET-BT has ta lık yay gın lı ğı nı ve te davi ya nı tı nı de ğer len dir me de et kin bir yön tem ola bi lir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : S...

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Extraorbital Sebaceous Carcinoma With Rapidly Developing Visceral Metastases

Abstract: Extraorbital SC may show a poor prognosis. Both the dermatologic surgeon and the dermatologist should be cautious of the risk of local recurrence and distant metastasis when dealing with extraorbital SC.

Cited by 25 publications

References 11 publications

The usefulness of dermoscopy in extraocular sebaceous carcinoma

The usefulness of dermoscopy in extraocular sebaceous carcinoma

A retrospective review of 1349 cases of sebaceous carcinoma

Aggressive Extra-Ocular Sebaceous Carcinoma Originating from Lumbar Skin with Disseminated Lymphadenopathies: A PET-CT Evaluation: Case Report

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