Extraordinarily high serum IgE levels and consequences for atopic phenotypes

Are age‐specific high serum IgE levels associated with worse symptomatology in children with atopic dermatitis?

“…Our finding that the severity of AD correlates with serum IgE levels is in agreement with that of Laske et al ; 1 however, we used Æ and recorded better correlations. The use of crude IgE values without the consideration of age‐specific references may be misleading and may undermine the usefulness of this readily available parameter for atopy.…”

“…Atopic dermatitis (AD) is a distressing disease associated with pruritus and sleep disturbance. The overall severity of AD has been reported to correlate with the levels of serum immunoglobulin E (IgE); 1,2 however, it is not known whether the subjective symptoms of pruritus and sleep loss or the objective signs of excoriations also correlate with the IgE levels. The symptomatology of AD is usually assessed using clinical scores.…”

Hand eczema and atopic dermatitis in adolescents: a prospective cohort study from the BAMSE project

“…To the best of our knowledge, no previous studies regarding hand eczema and specific IgE have been published. IgE sensitization is influenced by age, sex, lifestyle and genetic factors, and elevated total and/or allergen‐specific IgE level is the most commonly associated laboratory feature in patients with AD. Hand eczema is strongly associated with a variety of contact allergens but potential associations with food allergy and airborne allergens are less explored …”

IgE, Mast Cells, and Eosinophils in Atopic Dermatitis

“…Sensitization to both aeroallergens and food allergens was noted in 80% of the former group and 32% of the latter group. These authors concluded that children with very high serum IgE levels had more severe AD [17]. Another study investigated 345 children (mean age, 2.9 years) for a correlation of the severity of eczema and serum IgE levels.…”