Extraossäres Osteosarkom der Schilddrüse

Hertel, Victoria; Basten, O.; Bockmühl, Ulrike

doi:10.1055/s-2006-925096

Cited by 8 publications

(4 citation statements)

References 8 publications

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“…Osteosarcoma occurs most commonly in the long bones of teenagers and young adults. The extraosseous form of osteosarcoma accounts for less than 5% of all osteosarcomas, especially in the malignant non-epithelial neoplasms of the thyroid and has been reported in only several cases (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). Clinically, primary osteosarcoma of the thyroid presents as an aggressive, rapidly growing thyroid mass with a poor prognosis (4).…”

Section: Discussionmentioning

confidence: 99%

KMT2C mutation is a diagnostic molecular marker for primary thyroid osteosarcoma: A case report and literature review

Wang

et al. 2022

Front. Med.

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Primary thyroid osteosarcoma is an extremely rare tumor which is associated with a poor prognosis. In this study, we describe an additional case. A 4.5 × 3.8 cm irregular heterogeneous nodule was examined in the left thyroid gland of a 72-year-old woman. Cytological smears and histopathological specimens showed typical features of osteosarcoma with a neoplastic lesion rich in spindle cells with occasional multinucleated cells and lace-like osteoid matrix. Negative immunoreaction with epithelial markers and positive immunoreaction with SATB2 and low Ki-67 labeling index suggested the diagnosis of osteosarcoma. Multiple KMT2C gene mutations determined by next-generation sequencing further confirmed the diagnosis.

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Section: Discussionmentioning

confidence: 99%

KMT2C mutation is a diagnostic molecular marker for primary thyroid osteosarcoma: A case report and literature review

Wang

et al. 2022

Front. Med.

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“…However, these are rare incidents, described in single cases and involving the heart, lung, prostate, urinary bladder and breasts [1–4]. The extraosseous form of osteosarcoma occurs very rarely (approx.…”

Section: Discussionmentioning

confidence: 99%

“…It mimics anaplastic carcinoma with extensive osseous metaplasia [2, 3]. One of the conclusive tests is immunohistochemical staining, which excludes epithelial differentiation of the tumour [4]. We present a case of a female patient who underwent surgery due to a fast-growing tumour of the right thyroid lobe, with an unexpected final diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Primary osteosarcoma of the thyroid gland – a

Zembala‐Nożyńska

Lange²

2013

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A rare localization of primary osteosarcoma is presented. A woman aged 76 years was operated on for rapid growth of thyroid right lobe tumour. Histopathology showed anaplastic cancer with numerous foci of osseous metaplasia, negative with thyroglobulin, calcitonin, synaptophysin and chromogranin. A high proliferative activity of the tumour was observed (MIB-1 reaction) in the form of a positive reaction in approx. 40% of the tumour cell nuclei. The tumour stage was evaluated as pT4aNxMx according to the TNM scale. The reconsultation revealed negative staining with cytokeratin, and positive with vimentin, thereby confirming the mesenchymal origin of the tumour, with the final diagnosis being primary thyroid osteosarcoma. Taking into consideration the histopathological diagnosis, the extremely low radiation sensitivity of the tumour, the patient's age, the radical surgical treatment and persisting respiratory failure, radiotherapy was rejected in favour of further follow-up. The patient remains under oncological and endocrinological care.

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“…1 Primary osteosarcoma of the thyroid was first described by Foerster in 1860. In the past one and one-half centuries, only 27 well-documented primary osteosarcomas of the thyroid have been reported in the literature, [2][3][4][5][6][7][8] with only one in the cytology literature. Clinically, primary osteosarcoma of the thyroid presents as an aggressive, rapidly growing thyroid mass, similar to anaplastic thyroid carcinoma.…”

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confidence: 99%

Fine‐needle aspiration biopsy of primary osteosarcoma of the thyroid: Report of a case and review of the literature

Tong

Hamele‐Bena

Liu

et al. 2008

Diagnostic Cytopathology

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Primary osteosarcoma of the thyroid is an extremely rare tumor, with only 27 well-documented cases reported in the literature, including only one in the cytology literature. We describe here an additional case with fine-needle aspiration biopsy findings. A 60-year-old woman presented with a 1-month history of progressive midline neck swelling. CT and ultrasound demonstrated a large thyroid mass with tracheal compression. Fine-needle aspiration biopsies were performed and showed pleomorphic spindle and epithelioid neoplastic cells, multinucleated giant cells, and scant metachromatic extracellular matrix material. Cell block sections contained minute tissue fragments with neoplastic spindle cells. Immunohistochemical stains showed the tumor cells to be positive for vimentin and negative for cytokeratins, TTF-1, calcitonin, synatophysin, chromogranin, and S-100 protein, suggesting a sarcoma; however, the differential diagnosis also included anaplastic thyroid carcinoma and medullary thyroid carcinoma. Tissue biopsy revealed a high-grade spindle cell neoplasm with osteoid production, consistent with osteosarcoma of the thyroid. The patient developed a large pulmonary embolus and superior vena cava syndrome and no further surgical intervention was performed. She died 5 weeks after the initial diagnosis. Upon retrospective review, the cytologic features resemble osteosarcoma in other areas. Although cytologic features on fine-needle aspiration biopsy may suggest a diagnosis of this rare entity, definitive diagnosis should be deferred to histologic examination.

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Extraossäres Osteosarkom der Schilddrüse

Cited by 8 publications

References 8 publications

KMT2C mutation is a diagnostic molecular marker for primary thyroid osteosarcoma: A case report and literature review

KMT2C mutation is a diagnostic molecular marker for primary thyroid osteosarcoma: A case report and literature review

Primary osteosarcoma of the thyroid gland – a

Fine‐needle aspiration biopsy of primary osteosarcoma of the thyroid: Report of a case and review of the literature

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