Extraosseous Ewing Sarcoma: Expanding the Differential Diagnosis of Supraclavicular Fossa Tumors

Abstract

A broad spectrum of diseases can be included in the differential diagnosis of neck masses. We report a case of extraosseous Ewing sarcoma that presented as a neck mass in a 70-year-old man. To the best of our knowledge, this is the first reported case of extraosseous Ewing sarcoma of the supraclavicular fossa. Published cases of extraosseous Ewing sarcoma in the neck have been described in other age groups, but those tumors were confined to the parapharyngeal space. Also, there have been reported cases in patients older than 70 years in which Ewing sarcoma affected other structures such as the larynx and the pelvis, but none in the soft tissues of the neck. This case adds extraosseous Ewing sarcoma as a possible diagnosis to consider when evaluating a neck mass in the supraclavicular fossa.

Peripheral primitive neuroendocrine tumor of the chest wall—A case report with pathological correlation

“…There have been case reports of EO ES occurring in the kidney [4] , [5] , [6] , GI tract [7] , [8] , [9] , thyroid [10] , [11] , vagina [12] , [13] , [14] , and other more unusual locations such as the orbit [15] , adrenal gland [16] , and tonsil [17] . Fewer are seen in the thoracic region, with 1 reported case in the supraclavicular fossa [18] , and a few seen in the lung [19] , [20] . Peripheral PNET or EO ES originating from the chest wall was previously classified as Askin tumor [21] .…”