Extraosseous Manifestation of Multiple Myeloma with Unusual Appearance in Computed Tomography – Case Report

Heckmann, Martina; Uder, Michael; Grgic, Aleksandar; Adrian, Nicole; Bautz, W.; Heinrich, Marc

doi:10.1016/j.rontge.2008.03.003

“…Laboratory analysis may reveal abnormal liver biochemistry (7,8,10,13,14). Involvement of the liver can either appear as diffuse plasma cell infiltration, which can only be seen on microscopic examination, or scarce as spaceoccupying liver lesions with circumscribed tumour nodules like in our patient (6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Ultrasound as well as computed tomography can be used to identify mass lesions.…”

Section: Discussionmentioning

confidence: 85%

“…However, imaging features are non-specific and based on few published case reports. Moreover they cannot be used to distinguish between liver metastases from multiple myeloma or solid tumours (7,9,13,15).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Plasmablastic Myeloma Presenting with Nodular Liver Lesions: Rare but Important to Recognize

Boumans

¹

,

Hoekstra

²

,

Krukkert-Alberink

³

et al. 2014

Electron J Gen Med

0

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“…Per our literature search, eight cases of extramedullary plasmacytomas of the GB or biliary ducts were found [ 7 - 14 ]. Four cases were associated with MM, [ 9 - 10 , 12 , 14 ] and the other four were for solitary [ 7 - 8 , 11 , 13 ]. Table 2 summarizes these cases.…”

Section: Discussionmentioning

confidence: 99%

A Case of Multiple Myeloma Associated with Extramedullary Plasmacytoma of the Gallbladder Manifesting as Acute Cholecystitis

Abughanimeh¹,

Qasrawi²,

Omar³

et al. 2018

Cureus

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Multiple myeloma (MM) is a common hematological malignancy that represents 1% of all cancers. MM is distinguished from other plasma cell disorders by prominent bone marrow involvement and systemic organ damage. Extramedullary plasmacytomas of the gall bladder (GB) or biliary ducts, whether solitary or in association with MM, are very rare. We report a case of a 66-year-old female with a history of refractory MM who presented with right upper quadrant abdominal pain. Her laboratory evaluation revealed an abnormal liver panel and lactic acidosis. Abdominal ultrasonography was consistent with acute cholecystitis with no evidence of biliary obstruction or abnormal liver parenchyma. An open cholecystectomy with liver biopsy was performed. The histological evaluation revealed involvement of the GB submucosa and serosa, as well as the liver parenchyma by abnormal plasma cells with lambda light chain restriction. Congo red stain for the GB sample was positive. The patient declined further treatment for MM and was discharged home with comfort measures.

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“…However, MM can be complicated by secondary plasmacytomas, which are usually associated with a more aggressive course, shorter progression-free survival, and worse prognosis [1,4,[6][7]. The involvement of the gall bladder (GB) and biliary ducts by plasma cell neoplasms, whether solitary plasmacytomas or MM with secondary plasmacytomas, is rare [7][8][9][10][11][12][13][14]. The clinical and radiological manifestations of GB involvement can be confused with many benign and malignant diseases.…”

Section: Introductionmentioning

confidence: 99%

A Case of Multiple Myeloma Associated With Extramedullary Plasmacytoma of the Gallbladder Manifesting as Acute Cholecystitis

Ghanimeh

¹

,

Abughanimeh

²

,

Omar

³

et al. 2017

American Journal of Gastroenterology

0

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Multiple myeloma (MM) is a common hematological malignancy that represents 1% of all cancers. MM is distinguished from other plasma cell disorders by prominent bone marrow involvement and systemic organ damage. Extramedullary plasmacytomas of the gall bladder (GB) or biliary ducts, whether solitary or in association with MM, are very rare. We report a case of a 66-year-old female with a history of refractory MM who presented with right upper quadrant abdominal pain. Her laboratory evaluation revealed an abnormal liver panel and lactic acidosis. Abdominal ultrasonography was consistent with acute cholecystitis with no evidence of biliary obstruction or abnormal liver parenchyma. An open cholecystectomy with liver biopsy was performed. The histological evaluation revealed involvement of the GB submucosa and serosa, as well as the liver parenchyma by abnormal plasma cells with lambda light chain restriction. Congo red stain for the GB sample was positive. The patient declined further treatment for MM and was discharged home with comfort measures.

show abstract

Extraosseous Manifestation of Multiple Myeloma with Unusual Appearance in Computed Tomography – Case Report

Cited by 11 publications

References 9 publications

Plasmablastic Myeloma Presenting with Nodular Liver Lesions: Rare but Important to Recognize

Plasmablastic Myeloma Presenting with Nodular Liver Lesions: Rare but Important to Recognize

A Case of Multiple Myeloma Associated with Extramedullary Plasmacytoma of the Gallbladder Manifesting as Acute Cholecystitis

A Case of Multiple Myeloma Associated With Extramedullary Plasmacytoma of the Gallbladder Manifesting as Acute Cholecystitis

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