Extrapulmonary small-cell carcinoma of the liver

Abstract

A 53-year-old man was admitted to our hospital for the evaluation of a mass (13 x 10 cm) in the left lobe of the liver seen by imaging studies. On subsequent biopsy of the mass, the lesion was histologically diagnosed as malignant small round-cell tumor, consistent with metastatic small-cell carcinoma. Segment IV segmentectomy was performed. On pathological examination, the mass showed a yellowish-gray granular appearance with multifocal hemorrhage and necrosis. The phenotypes shown by immunohistochemistry revealed characteristic patterns of small-cell carcinoma (neuron-specific enolase [NSE]+, synaptophysin+, c-Kit+, cluster designation [CD]56+, epithelial membrane antigen [EMA]+, cytokeratin [CK]7-). High resolution-computed tomography (HRCT) revealed inactive pulmonary tuberculosis with small calcified tuberculoma in the right upper lobe. Sputum cytology was negative for malignancy. The postoperative course was uneventful, and platinum-based chemotherapy (cisplatin, etoposide) was initiated.

Primary small cell carcinoma of the esophagus: clinicopathological and immunohistochemical features of 21 cases

“…It is a highly aggressive tumor associated with a poor prognosis, similar to SCC that arises in the lung [2] and other extrapulmonary organs, including breast [3], ovary [4], uterine cervix [5], liver [6], salivary gland [7], stomach [8], colon [9], prostate [10], urinary bladder [11], and kidney [12]. Histologically, SCC is characterized by neuroendocrine-like architectural patterns, including nested and trabecular growth with common features including peripheral palisading and rosette formation in the tumors [2-12].…”

Undifferentiated carcinoma of the liver: a case report with immunohistochemical analysis

“…Extrapulmonary small cell carcinomas are extremely rare and can originate in a variety of sites, including the liver, colon, stomach, esophagus, cervix, gallbladder, and skin [9–14]. Zanconati et al [9] reported three cases of unusual small cell primary carcinoma of the liver.…”

Primary Small Cell Carcinoma of Liver: A Rare Tumor

“…In the two cases reported by Sengoz et al [9], one patient who received chemotherapy survived for 13 months and the other survived for 67 months after hemihepatectomy. Kim et al [10] reported a case in which segmentectomy of the liver and adjuvant chemotherapy were performed, the patient survived with no signs of recurrence for at least 4 months. In other 5 reported cases, 2 patients received combined chemotherapy [11, 12], and two underwent resection [13, 14] and one received no treatment [2].…”