Extrapyramidal Features in Central Lyme Borreliosis

Kohlhepp, W.; Kühn, Wilfried; Krüger, Horst

doi:10.1159/000116399

Cited by 33 publications

(9 citation statements)

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“…Our patient developed generalised chorea following a bout of cocaine use, which had disappeared at followup six months later. s Chorea associated with infection or outcome of rheumatic fever Extrapyramidal signs occur rarely in association with borreliosis, and have been described in less than 2 % of such patients with neurological disturbances [16]. In the case in this series (patient 38), reported previously, [24] MRI revealed deep white matter lesions similar to those often found in multiple sclerosis and signal hypointensity in the putamina.…”

Section: Discussionmentioning

confidence: 46%

Cause and course in a series of patients with sporadic chorea

Piccolo

Defanti

Soliveri³

et al. 2003

Journal of Neurology

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Although a convincing concordance between choreic signs and neuroradiological findings was possible in 4 patients only, it was possible to assign an aetiology in most cases with vascular related causes the most frequent and metabolic factors often participating. Huntington's disease is not unusual as a cause of sporadic choreas. HIV infection is an emerging cause of chorea and AIDS-related disease should be considered in young patients presenting without a family history of movement disorders. We emphasize the importance of follow-up to identify persistent chorea for which genetic testing is mandatory.

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Section: Discussionmentioning

confidence: 46%

Cause and course in a series of patients with sporadic chorea

Piccolo

Defanti

Soliveri³

et al. 2003

Journal of Neurology

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“…Cases with predominant meningeal involvement have been mistaken for tuberculous meningitis [44]. Other rare cases present as extrapyramidal [45, 46] or as psychiatric disorders, such as schizophrenia-like psychosis [47–50], catatonia [51] or mania [52]. In all cases with dementia-like syndromes reported in our review, LNB was originally not taken into consideration.…”

Section: Resultsmentioning

confidence: 99%

Secondary dementia due to Lyme neuroborreliosis

Kristoferitsch

Aboulenein-Djamshidian

Jecel

et al. 2018

Wien Klin Wochenschr

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SummaryDementia-like syndromes are rare manifestations of Lyme neuroborreliosis. The clinical patterns are summarized using our own cases and case reports from the literature, which were diagnosed as definite Lyme neuroborreliosis according to the European guidelines. The cases disclose signs of subcortical dementia that occur more rapidly than in patients suffering from primary dementia. Gait disturbances early in the disease course is another frequently observed characteristic feature. The response to 2–4 weeks of antibiotic treatment with ceftriaxone was excellent. There were no indications for a prolonged antibiotic treatment. It is essential to be aware of this manifestation of Lyme neuroborreliosis, because early antibiotic treatment will prevent permanent sequelae that may occur throughout the further course of the untreated disease.

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“…In some cases, the magnetic resonance (MR) picture is characterised by multiple bilateral periventricular focal lesions that are similar to the plaques observed in patients with multiple sclerosis (MS), but the two can be distinguished by the presence of anfi-Borrelia antibodies in cerebrospinal fluid [3,8]. Movement disorders are rare in patients with Lyme disease, although choreic dyskinesias have been observed during the course of mild encephalitis [9,10].…”

Section: Introductionmentioning

confidence: 99%

Chorea as a symptom of neuroborreliosis: a case study

et al. 1998

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Borrelia burgdorferi (Bb) can cause a large number of neurological symptoms. Although extrapyramidal disturbances are rare (representing less than 2% of all neurological complications), diffuse choreic dyskinesias have been described during the course of mild encephalitis. The data published in the literature suggest that there are clinical and neurological analogies between neuroborreliosis and multiple sclerosis (MS). The presence of specific anti-Bb antibodies in cerebrospinal fluid is a discriminating factor that allows a diagnosis of neuroborreliosis to be made. We describe the case of a patient with Lyme disease, characterised by widespread chorea and behavioural disturbances. Emphasis is placed on the atypical onset and evolution, the difficulties encountered in formulating a diagnosis, and the uncertainties concerning the pathophysiology and clinical/neuroradiological correlations of the disease.

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Extrapyramidal Features in Central Lyme Borreliosis

Abstract: We report 5 cases with an extrapyramidal syndrome resulting from Borrelia burgdorferi encephalitis which responded to antibiotic treatment. The acute onset of extrapyramidal features together with diffuse pain can be the leading symptoms of central borreliosis.

Cited by 33 publications

References 0 publications

Cause and course in a series of patients with sporadic chorea

Cause and course in a series of patients with sporadic chorea

Secondary dementia due to Lyme neuroborreliosis

Chorea as a symptom of neuroborreliosis: a case study

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