Extraskeletal Ewing's Sarcoma Family of Tumors in Adults: Prognostic Factors and Clinical Outcome

Tural, Deniz; Mandel, Nil Molınas; Dervışoğlu, Sergülen; Dinçbaş, Fazilet Öner; Koca, Sevim Baykal; Öksüz, Didem Çolpan; Kantarcı, Fatih; Turna, Hande; Selçukbiricik, Fatih; Hız, Murat

doi:10.1093/jjco/hys027

Cited by 63 publications

(60 citation statements)

References 25 publications

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“…Our series focused on late adolescents and adult patients with EES/PNET, and was the first report of Asian. The median age at diagnosis in our patients was 28 years, whereas other previous studies' median age was 20-26 years (Rud et al, 1989;Baldini et al, 1999;Eralp et al, 2002;El et al, 2010;Tural et al, 2012). 65% of the patients in the study were men.…”

Section: Discussioncontrasting

confidence: 65%

“…Several studies have demonstrated the prognostic impacts on tumour stages (localized vs metastatic), sizes, surgical margins, high lactate dehydrogenase, present of CR to initial treatment (Kinsella et al, 1983;Rud et al, 1989;Raney et al, 1997;Ahmad et al, 1999;Eralp et al, 2002;El et al, 2010;Applebaum et al, 2011;Shannon et al, 2012;Tural et al, 2012).…”

Section: Extraskeletal Ewing Sarcomas In Late Adolescencementioning

confidence: 99%

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Extraskeletal Ewing Sarcomas in Late Adolescence and Adults: A Study of 37 Patients

Tao

Hu²,

Wang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Extraskeletal Ewing sarcoma (EES)/primitive neuroectodermal tumours (PNET) are rare soft tissue sarcomas. Prognostic factors and optimal therapy are still unconfirmed. Materials and Methods: We performed a retrospective analysis on patients to explore the clinic characteristics and prognostic factors of this rare disease. A total of 37 patients older than 15 years referred to our institute from Jan., 2002 to Jan., 2012 were reviewed. The characteristics, treatment and outcome were collected and analyzed. Results: The median age was 28 years (range 15-65); the median size of primary tumours was 8.2 cm (range 2-19). Sixteen patients (43%) had metastatic disease at the initial presentation. Wide surgical margins were achieved in 14 cases (38%). Anthracycline or platinum-based chemotherapy was performed on 29 patients (74%). Radiotherapy was delivered in 13 (35%). At a median follow-up visit of 24 months (range 2-81), the media event-free survival (EFS) and overall survival (OS) were 15.8 and 30.2 months, respectively. The 3-year EFS and OS rates were 24% and 43%, respectively. Metastases at presentation and wide surgical margins were significantly associated with OS and EFS. Tumour size was significantly associated with OS but not EFS. There were no significant differences between anthracycline and platinum based chemotherapy regarding EFS and OS. Conclusions: EES/PNET is a malignant tumour with high recurrence and frequent distant metastasis. Multimodality therapy featuring wide surgical margins, aggressive chemotherapy and adjuvant local radiotherapy is necessary for this rare disease. Platinum-based chemotherapy can be used as an adjuvant therapy.

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Section: Discussioncontrasting

confidence: 65%

Section: Extraskeletal Ewing Sarcomas In Late Adolescencementioning

confidence: 99%

Extraskeletal Ewing Sarcomas in Late Adolescence and Adults: A Study of 37 Patients

Tao

Hu²,

Wang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…The patients had obviously better disease even those had been received only surgical resection. Extraskeletal Ewing's sarcoma considers as a poor prognostic factor (Tural et al, 2012;Somarouthu et al, 2014), however the outcome of the patients in our study that mainly were skeletal was worse than that Tao HT et al (2013) reported in extraskeletal Ewing's sarcoma in China. In this study median event free survival and overall survival for entire group were 15.8 months and 30.2 months respectively.…”

Section: Discussioncontrasting

confidence: 76%

Survival of Patients with Ewing's Sarcoma in Yazd-Iran

Akhavan

Binesh²,

Shamshiri³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: The Ewing's sarcoma family is a group of small round cell tumors which accounts for 10-15% of all primary bone neoplasms. The aim of this study was to evaluate the survival of Ewing's sarcoma patients in our province and to determine of influencing factors. Materials and Methods: All patients with documented Ewing's sarcoma/ primitive neuroectodermal tumor(PNET) family pathology were enrolled in this study during a period of eight years. For all of them local and systemic therapy were carried out. Overall and event free survival and prognostic factors were evaluated. Results: Thirty two patients were enrolled in the study. The median age was 17.5 years. Twenty (65.2%) were male and 9 (28.1%) were aged 14 years or less. Mean disease free survival was 26.8 (95%CI; 13.8-39.9) months and five year disease free survival was 26%. Mean overall survival was 38.7 months (95%CI; 25.9-50.6) and median overall survival was 24 months. Five year overall survival was 25%. From the variables evaluated , only presence of metastatic disease at presentation (p value=0. 028) and complete response (p value =0. 006) had significant relations to overall survival. Conclusions: Survival of Ewing's sarcoma in our province is disappointing. It seems to be mostly due to less effective treatment. Administration of adequate chemotherapy dosage, resection of tumor with negative margins and precise assessment of irradiation volume may prove helpful.

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“…Egger's test (19,20,(22)(23)(24)(25). The funnel plot for this meta-analysis revealed evidence of symmetry, and the P-value from the Egger's test was 0.707 in the OS studies (Fig.…”

Section: Meta-analysismentioning

confidence: 83%

“…1 shows a flow diagram of the selection process for defining the relative studies. Following the process of selection, nine studies met the inclusion criteria and were included in the meta-analysis (17)(18)(19)(20)(21)(22)(23)(24)(25). The major characteristics of the nine eligible publications are shown in Table I.…”

Section: Resultsmentioning

confidence: 99%

Prognostic significance of serum lactate dehydrogenase levels in Ewing's sarcoma: A meta-analysis

Yang

Wang

et al. 2016

Molecular and Clinical Oncology

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Abstract.A number of studies have investigated the role of serum lactate dehydrogenase (LDH) levels in patients with Ewing's sarcoma, although these have yielded inconsistent and inconclusive results. Therefore, the present study aimed to systematically review the published studies and conduct a meta-analysis to assess its prognostic value more precisely. Cohort studies assessing the prognostic role of LDH levels in patients with Ewing's sarcoma were included. A pooled hazard ratio (HR) with 95% confidence intervals (CIs) of overall survival (OS) or 5-year disease-free survival (DFS) was used to assess the prognostic role of the levels of serum LDH. Nine studies published between 1980 and 2014, with a total of 1,412 patients with Ewing's sarcoma, were included. Six studies, with a total of 644 patients, used OS as the primary endpoint and four studies, with 795 patients, used 5-year DFS. Overall, the pooled HR evaluating high LDH levels was 2.90 (95% CI: 2.09-4.04) for OS and 2.40 (95% CI: 1.93-2.98) for 5-year DFS. This meta-analysis demonstrates that high levels of serum LDH are associated with lower OS and 5-year DFS rates in patients with Ewing's sarcoma. Therefore, serum LDH levels are an effective biomarker of Ewing's sarcoma prognosis.

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Extraskeletal Ewing's Sarcoma Family of Tumors in Adults: Prognostic Factors and Clinical Outcome

Cited by 63 publications

References 25 publications

Extraskeletal Ewing Sarcomas in Late Adolescence and Adults: A Study of 37 Patients

Extraskeletal Ewing Sarcomas in Late Adolescence and Adults: A Study of 37 Patients

Survival of Patients with Ewing's Sarcoma in Yazd-Iran

Prognostic significance of serum lactate dehydrogenase levels in Ewing's sarcoma: A meta-analysis

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