Extraskeletal Giant Cell Tumor of the Larynx: Case Report and Review of the Literature

Rochanawutanon, Mana; Praneetvatakul, Phurich; Laothamatas, Jiraporn; Sirikulchayanonta, Vorachai

doi:10.1177/014556131109000509

Cited by 11 publications

(3 citation statements)

References 19 publications

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“…GCT has been described in sites of endochondral bone ossification in the skull base. Previous reports have described GCT of the larynx arising from the endochondral bone of the laryngeal skeleton, except for a case report of an extraosseous subglottic soft tissue giant cell tumor of the larynx [6] . There is no typical radiological appearance.…”

Section: Discussionmentioning

confidence: 97%

Giant cell tumor of paralaryngeal soft tissues, extending to the laryngeal cartilage

Maia Segundo,

Mello,

Furlan

et al. 2024

Radiology Case Reports

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Section: Discussionmentioning

confidence: 97%

Giant cell tumor of paralaryngeal soft tissues, extending to the laryngeal cartilage

Maia Segundo,

Mello,

Furlan

et al. 2024

Radiology Case Reports

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“…4 Rare cases have been reported in the head and neck region. 4,[10][11][12] To the best of our knowledge, 19 head and neck GCTSTs have been published in the English literature since its first description in 1972. Five of the 19 cases were located in the neck, 3 in the parotid, one laryngeal, 12 one intranasal, and one intracranial (mimicking a glioma).…”

Section: Discussionmentioning

confidence: 99%

“…4,[10][11][12] To the best of our knowledge, 19 head and neck GCTSTs have been published in the English literature since its first description in 1972. Five of the 19 cases were located in the neck, 3 in the parotid, one laryngeal, 12 one intranasal, and one intracranial (mimicking a glioma). 5 The remaining 8 arose in superficial soft tissue of the head: forehead (1 case), temporal area (1 case), cheek (2 cases), lip (2 cases), ear (1 case), and paranasal region (1 case).…”

Section: Discussionmentioning

confidence: 99%

Periocular Cutaneous Soft-Tissue Giant Cell Tumor in a Pediatric Patient

Hogeboom

Gallardo²,

Delgado-Muñoz

et al. 2021

The American Journal of Dermatopathology

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Giant cell tumor of soft tissue (GCTST) is a rare neoplasm genetically unrelated but histopathologically indistinguishable to its osseous counterpart. Histologically, GCTST is characterized as a multinodular proliferation of bland histiocytoid mononuclear cells intermixed with osteoclast-like giant cells. GCTST most commonly presents as a soft-tissue mass located in the extremities of middle-aged adults. In this report, we describe a case of a dermal GCTST arising in the periocular region of a 3year-old girl. This is the youngest patient diagnosed with GCTST reported in the literature and is also singular because of its anatomic location: Only a handful of head and neck GCTSTs have been reported to date. Furthermore, GCTST most often presents as a superficial or deep soft-tissue mass and much less commonly as a dermal-based skin tumor, as was our case. On microscopic examination, the resected lesion demonstrated classical features including numerous osteoclast-like giant cells embedded in a background of mononuclear ovoid cells which displayed brisk mitotic activity and were surrounded by variable stromal hemorrhage. Tumor cells presented a vaguely fascicular arrangement. Immunohistochemical profile demonstrated positivity for smooth muscle actin and CD68 and negativity for desmin, myo-D1, S100, HMB-45, Melan-A, p16, and NKIC3. The unusual characteristics of this case emphasize the clinicopathologic heterogeneity of GCTST.

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