Extraskeletal myxoid chondrosarcoma of the thigh with a t(9;17) translocation

Yasuda, Taketoshi; Hori, Takeshi; Suzuki, Kayo; Koike, Masahiko; Nogami, Shigeharu; Yahara, Yasuhito; Kimura, Takeshi

doi:10.3892/ol.2011.526

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Extraskeletal myxoid chondrosarcoma, is a slow-growing tumor characterized, histologically, by prominent myxoid degeneration and a prolonged course, despite the high incidence of local recurrence (Yasuda et al, 2012). Extraskeletal myxoid chondrosarcoma has been considered by the World Health Organization as a differentiated tumors in cancer classification (Fletcher and Unni, 2002).…”

Section: Chondrosarcomamentioning

confidence: 99%

Biomarkers of Osteosarcoma, Chondrosarcoma, and Ewing Sarcoma

et al. 2017

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Osteosarcoma is the most frequent malignant bone neoplasm, followed by chondrosarcoma and Ewing sarcoma. The diagnosis of bone neoplasms is generally made through histological evaluation of a biopsy. Clinical and radiological features are also important in aiding diagnosis and to complete the staging of bone cancer. In addition to these, there are several non-specific serological or specific molecular markers for bone neoplasms. In bone tumors, molecular markers increase the accuracy of the diagnosis and assist in subtyping bone tumors. Here, we review these markers and discuss their role in the diagnosis and prognosis of the three most frequent malignant bone neoplasms, namely osteosarcoma, chondrosarcoma, and Ewing sarcoma.

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Section: Chondrosarcomamentioning

confidence: 99%

Biomarkers of Osteosarcoma, Chondrosarcoma, and Ewing Sarcoma

et al. 2017

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“…ES/PNET are highly malignant small round cell tumors with multidirectional differentiation potential and can be classified as intraosseous and extraosseous depending on their origin in bone or soft tissue (2). Extraosseous Ewing's sarcoma (EES)/PNET is an extremely rare primary malignant tumor with rapid progression and poor prognosis (3). EES/PNET has been reported mainly in the chest wall, lower extremities and paravertebral regions, followed by the upper extremities, hip and pelvis, and rarely in the epidural space, especially at the cervicothoracic junction (4,5).…”

Section: Introductionmentioning

confidence: 99%

A case of giant Ewing's sarcoma (EES)/primitive neuroectodermal tumor (PNET) of the cervicothoracic junction in children with incomplete paralysis of both lower limbs: Case report and literature review

Zhang

Lin

et al. 2023

Front. Surg.

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BackgroundExtraosseous Ewing's sarcoma/primary neuroectodermal tumor (EES/PNET) is a rare, malignant, small round blue cell tumor, which usually involves the larynx, kidneys, and esophagus. The most common metastatic sites are lung and bone. The incidence of epidural EES/PNET was 0.9%, and a detailed search of the PubMed literature found only 7 case reports of epidural ESS/PNET at the cervicothoracic junction in children.Case descriptionWe report a case of epidural ESS/PNET at the cervicothoracic junction in a child with chest and back pain as the first symptom, which worsened after half a year and developed incomplete paralysis of both lower extremities and urinary incontinence. She underwent emergency surgery, chemotherapy and radiotherapy, and died of lung metastases 8 months after surgery.ConclusionPrimary epidural tumors are mostly benign, such as spinal meningiomas and neuromas. Contrary to what has been previously thought, we report a case of malignant epidural EES/PNET at the cervicothoracic junction without bone destruction; The rarity of epidural EES/PNET at the cervicothoracic junction in children has led to a lack of data, particularly on prognostic factors and recurrence patterns. Due to the difficulty of early diagnosis and high mortality, spine surgeons must explore and increase their awareness of this disease.

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Extraskeletal myxoid chondrosarcoma arising in the femoral vein: a case report

et al. 2014

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Soft tissue tumors arising in deep veins of the extremities are uncommon, although a few cases of synovial sarcoma or leiomyosarcoma arising in the femoral vein have been documented. However, to the best of our knowledge, an extraskeletal myxoid chondrosarcoma (EMC) arising in the femoral vein has not been reported in the English literature. We report a case of EMC arising in the femoral vein of a 70-year-old man who presented with right leg edema and was diagnosed with a deep venous thrombosis (DVT) by computed tomography (CT). Magnetic resonance imaging (MRI) revealed a mass in the right proximal thigh that was diagnosed as myxomatous sarcoma by aspiration cytology, and anticoagulant therapy was initiated. The mass was surgically resected en bloc, including the femoral vein and surrounding soft tissue, and the femoral artery was preserved. The femoral vein was not reconstructed. The histologic diagnosis was an extraskeletal myxoid chondrosarcoma. The patient received postoperative local radiation treatment, with a total dose of 60 Gy, and is currently doing well with no evidence of local recurrence or metastasis at 8 months after surgery. In summary, this case report shows that EMC can arise in the femoral vein, and that reconstruction of the femoral vein is not always necessary during surgery for soft tissue tumors.

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Extraskeletal myxoid chondrosarcoma of the thigh with a t(9;17) translocation

Cited by 3 publications

References 27 publications

Biomarkers of Osteosarcoma, Chondrosarcoma, and Ewing Sarcoma

Biomarkers of Osteosarcoma, Chondrosarcoma, and Ewing Sarcoma

A case of giant Ewing's sarcoma (EES)/primitive neuroectodermal tumor (PNET) of the cervicothoracic junction in children with incomplete paralysis of both lower limbs: Case report and literature review

Extraskeletal myxoid chondrosarcoma arising in the femoral vein: a case report

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