Extraskeletal myxoid chondrosarcoma with dedifferentiation

Ramesh, K; Gahukamble, L. D.; Sarma, N. H.; Fituri, O.M. Al

doi:10.1111/j.1365-2559.1995.tb01531.x

Cited by 19 publications

(13 citation statements)

References 5 publications

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“…However, it remains unclear whether histological signs of aggressive behavior, such as dedifferentiation, Ki-67 staining, mitotic rate, and necrosis provide additional prognostic information. Anecdotally, our case is remarkably similar to a previously reported case of EMC, in which excision of the primary mass was followed by growth of a recurrent, dedifferentiated tumor and rapid clinical deterioration with metastatic disease [12]. …”

Section: Discussionsupporting

confidence: 83%

A Case of Highly Aggressive Extraskeletal Myxoid Chondrosarcoma

Mitchell

Poiesz

Leung³

2011

Case Rep Oncol

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Extraskeletal myxoid chondrosarcoma (EMC) is a soft tissue malignancy characterized by specific chromosomal abnormalities involving the TEC gene. This disease has historically been considered largely indolent both histologically and clinically. Rarer subsets of EMC exist that demonstrate aggressive histopathologic features and clinical behavior, though it remains unclear whether or not aggressive histopathology is predictive of outcome. Herein we present a case of EMC with aggressive histopathologic features that underwent rapid clinical progression despite initial treatment with curative intent. This case provides the context for a discussion of the existing literature regarding treatment, prognosis, pathology, and genetic/molecular features of EMC in general and aggressive EMC specifically.

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Section: Discussionsupporting

confidence: 83%

A Case of Highly Aggressive Extraskeletal Myxoid Chondrosarcoma

Mitchell

Poiesz

Leung³

2011

Case Rep Oncol

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“…Ueda et al 7 reported a case of low-grade EMC that transformed into a high-grade tumour when it recurred; similar to our case 1. Ramesh et al 6 reported a case of dedifferentiated EMC that consisted of low-grade EMC juxtapposed to high-grade spindle cell sarcoma. We also observed spindle cell sarcomatous differentiation in one of our cases (case 2).…”

Section: Discussionmentioning

confidence: 99%

High‐grade extraskeletal myxoid chondrosarcoma: a high‐grade epithelioid malignancy

Lucas¹,

Fletcher

Adsay³

et al. 1999

Histopathology

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“…Tumors with dedifferentiation are known to have an aggressive clinical course. 8 There have been few case reports 3,4,6,7 on fine needle aspiration cytology (FNAC) of EMC. We describe the cytologic findings in a case with no ap-parent chondroid differentiation, diagnosed by fine needle aspiration cytology and confirmed by histopathology.…”

Section: Background: Extraskeletal Myxoid Chondrosarcoma Is a Rare Somentioning

confidence: 99%