2018
DOI: 10.1159/000487544
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Extraskeletal Osteosarcoma: A Rare Case Arising in Phthisis Bulbi with a Review of the Literature

Abstract: A 60-year-old male presented with an increasingly painful and swollen phthisical eye. Enucleation revealed a large mass obliterating the eye with extension into the adjacent extraocular muscle. Histologic examination showed high-grade osteosarcoma. Systemic work-up showed no disease elsewhere, and a diagnosis of orbital extraskeletal osteosarcoma was rendered. Complete resection was not possible, and neoadjuvant radiation was given. The patient subsequently developed pulmonary metastasis and died of disease 5 … Show more

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Cited by 5 publications
(2 citation statements)
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“…This patient was diagnosed with primary extraskeletal osteosarcoma, osteoblastic type, grade 3 (high-grade) histologically, stage pT2N0M0. Extraskeletal osteosarcoma is characterized by production of osteoid matrix by neoplastic cells arising without connection to the skeletal system [8]. The histomorphological spectrum of extraskeletal osteosarcomas is broad and similar to that seen in skeletal osteosarcomas [9].…”
Section: Discussionmentioning
confidence: 99%
“…This patient was diagnosed with primary extraskeletal osteosarcoma, osteoblastic type, grade 3 (high-grade) histologically, stage pT2N0M0. Extraskeletal osteosarcoma is characterized by production of osteoid matrix by neoplastic cells arising without connection to the skeletal system [8]. The histomorphological spectrum of extraskeletal osteosarcomas is broad and similar to that seen in skeletal osteosarcomas [9].…”
Section: Discussionmentioning
confidence: 99%
“…The stain for the Ki-67 analogous MIB-1 shows high proliferative activity with values around 25%. Systematic genetic differences between extraskeletal and bone osteosarcomas have not documented [ 7 , 8 ] The previous analysis highlighted several factors associated with a better outcome include size less than 5 cm (the most important), fibroblastic or chondroblastic histological subtype, and diminished proliferative activity as measured by Ki-67 index. However, the validity of these prognostic factors is controversial [ 9 , 10 ].…”
Section: Discussionmentioning
confidence: 99%