Extraskeletal Osteosarcoma Associated with Retained Surgical Sponge in a Dog

Miller, Margaret A.; Aper, Rhonda L.; Fauber, Amy E.; Blevins, William E.; Ramos‐Vara, José A.

doi:10.1177/104063870601800218

Cited by 45 publications

(55 citation statements)

References 17 publications

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“…Microchips have been shown to elicit sarcomas in mice [184]. An osteosarcoma has been reported at the site of a retained surgical sponge in the dog [185]. Aluminium has been detected in an injection-site sarcoma resected from a cat [32, 92].…”

Section: The Possible Role Of Chronic Inflammationmentioning

confidence: 99%

Origins of Injection-Site Sarcomas in Cats: The Possible Role of Chronic Inflammation—A Review

Woodward¹

2011

ISRN Veterinary Science

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The etiology of feline injection-site sarcomas remains obscure. Sarcomas and other tumors are known to be associated with viral infections in humans and other animals, including cats. However, the available evidence suggests that this is not the case with feline injection-site sarcomas. These tumors have more in common with sarcomas noted in experimental studies with laboratory animals where foreign materials such as glass, plastics, and metal are the causal agent. Tumors arising with these agents are associated with chronic inflammation at the injection or implantation sites. Similar tumors have been observed, albeit infrequently, at microchip implantation sites, and these also are associated with chronic inflammation. It is suggested that injection-site sarcomas in cats may arise at the administration site as a result of chronic inflammation, possibly provoked by adjuvant materials, with subsequent DNA damage, cellular transformation, and clonal expansion. However, more fundamental research is required to elucidate the mechanisms involved.

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Section: The Possible Role Of Chronic Inflammationmentioning

confidence: 99%

Origins of Injection-Site Sarcomas in Cats: The Possible Role of Chronic Inflammation—A Review

Woodward¹

2011

ISRN Veterinary Science

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“…These reports are mainly focused on imaging of the foreign bodies (Lamb and others 1994, Merlo and Lamb 2000) although osteomyelitis (Teague and others 1978) and development of neoplasia (Pardo and others 1990, Miller and others 2006, Haddad and others 2010) was reported in several small animals, at the site of swab retention many years after original surgery. This scarcity of reports within the veterinary literature suggests either the incidence is very low, or that retained swabs do not cause a clinical problem in veterinary cases.…”

mentioning

confidence: 99%

Retained surgical swabs in 13 dogs

Forster

Anderson²,

Yool

et al. 2013

Vet Record Case Reports

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To report the signalment, history, clinical signs, diagnostic and surgical findings and outcome in dogs and cats with retained swabs, medical records of dogs and cats that were referred to four referral centres were reviewed. Cases in which a retained surgical swab was identified during surgery at the referral hospital were selected for further study. The signalment, history, clinical signs, diagnostic and surgical findings and outcome in these cases were reviewed. Thirteen dogs with retained surgical swabs were included in the study. Bodyweight ranged from 9 to 45 kg. The initial surgery was a ‘non-routine’ abdominal procedure in seven dogs, ovariohysterectomy in five dogs and perineal hernia repair in one dog. Time from initial surgery to presentation at the referral centre ranged from four days to seven years. Treatment involved major surgery in eight of the 13 dogs. Outcome was excellent in 12 of 13 cases, one dog was euthanased.

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“…In contrast to human cases, most canine extraskeletal osteosarcomas arise from the viscera rather than from the subcutaneous tissues (2). Of the few canine cases reported in the subcutaneous tissues, one report described cases involving four dogs (1) and another occurred in a 7-year-old spayed female Labrador retriever (3), while the most recently reported cases were in seven dogs (8), in an 11-year-old spayed female Labrador retriever (associated with a retained surgical sponge) (9), and in a 6-year-old spayed female Labrador retriever (associated with injection) (10). The majority of cases have thus been reported in larger breeds of dog, with no reports specifically involving smaller breeds.…”

Section: Resultsmentioning

confidence: 99%

Extraskeletal chondroblastic osteosarcoma of the subcutaneous tissue in a Maltese dog

Seung¹,

Ju²,

Kyung³

et al. 2017

Turk J Vet Anim Sci

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A 10-year-old spayed female Maltese dog presented to a local animal hospital with a subcutaneous mass (4 × 3 × 3 cm) in the right shoulder region. The mass was well circumscribed, with soft tissue opacity and variable levels of mineralization, but with no bony involvement in radiography. The mass was surgically removed. Upon histological examination, the mass consisted of malignant mesenchymal cells that had produced a chondroid matrix and osteoid. Round to polygonal neoplastic cells with large nuclei showed moderate anisokaryosis and variable numbers of mitotic figures. The tumor cells were positive for vimentin and osteocalcin and negative for pancytokeratin, S100, and C-kit. On the basis of histopathologic and immunohistochemical features, the tumor was diagnosed as an extraskeletal chondroblastic osteosarcoma.

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Extraskeletal Osteosarcoma Associated with Retained Surgical Sponge in a Dog

Cited by 45 publications

References 17 publications

Origins of Injection-Site Sarcomas in Cats: The Possible Role of Chronic Inflammation—A Review

Origins of Injection-Site Sarcomas in Cats: The Possible Role of Chronic Inflammation—A Review

Retained surgical swabs in 13 dogs

Extraskeletal chondroblastic osteosarcoma of the subcutaneous tissue in a Maltese dog

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