Extraskeletal osteosarcomas in dogs: a retrospective study of 169 cases (1986-1996)

Langenbach, Andreas; Anderson, M A; Dambach, Dm; Sørenmo, Karin U.; Shofer, F. S.

doi:10.5326/15473317-34-2-113

Cited by 102 publications

(192 citation statements)

References 12 publications

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“…It was shown that appendicular OSA carries worse prognosis than OSA situated in the axial skeleton (Nagamine et al 2015). The less common form of canine OSA are extra-skeletal (or soft tissue) tumors that show aggressive biological behaviour with high rate of recurrences (Langenbach et al 1998, Duffy et al 2015. Histological morphology of canine OSA is heterogeneous with numerous subtypes possible to diagnose in the microscopic examination, however, histologic subtyping of these neoplasms seems not to have any prognostic value (Nagamine et al 2015).…”

Section: Introductionmentioning

confidence: 99%

The animal-dependent risk factors in canine osteosarcomas

Sapierzyński¹,

Czopowicz²

2017

Polish Journal of Veterinary Sciences

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Canine osteosarcoma (OSA) is a malignant neoplastic tumor, which develops from the primitive mesenchymal stem cell, that has or can acquire the capacity to produce neoplastic osteoid with possible neoplastic bone formation. Predisposition of some dog breeds to OSA indicates genetic background of oncogenesis. The aim of the study was to characterize animal-dependent risk factors for canine osteosarcoma development in Poland. The study was conducted on canine patients diagnosed cytologically or histopathologically as having OSA, and data on age, breed, sex, as well as tumor location and character were recorded. No sex predisposition to OSA was observed, mongrels were significantly underrepresented. Large and giant dogs accounted for 47% and 35% of all pedigree dogs, respectively, and both proved predisposed to OSA. A vast majority of OSA developed in the skeleton (appendicular skeleton was more commonly affected than axial skeleton), soft tissues were affected less often. Rottweiler dogs are strongly predisposed to OSA, suggesting that the genetic background is involved in the tumor development, and indicates that dogs of this breed are a promising object for further studies on OSA pathogenesis.

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Section: Introductionmentioning

confidence: 99%

The animal-dependent risk factors in canine osteosarcomas

Sapierzyński¹,

Czopowicz²

2017

Polish Journal of Veterinary Sciences

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“…In dogs, EOS occurs mainly in older animals and is observed in several locations [23,30], especially the mammary glands [30]. Mammary gland osteosarcoma (MGO) has aggressive biological behavior, and commonly shows pulmonary metastasis [23].…”

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confidence: 99%

Establishment and Characterization of a Cell Line, MCO-Y4, Derived from Canine Mammary Gland Osteosarcoma

Kawabata

Yamamoto

Lan

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. A cell line, MCO-Y4, was established from a mammary gland osteosarcoma of a 16-year-old female mongrel dog. Histopathologically the tumor was composed of osteoblastic cells with an osteoid meshwork and chondroid matrix. The mean doubling time of the cells at the 93rd passage was 32.39 ± 4.66 hr. Immunohistochemically, the osteoblastic and chondroblastic cells were positive for bone morphogenetic protein (BMP)-2/4 and BMP receptor (BMPR) II. The cultured cells were spindle in shape during the growth and the confluent phases. No tumor matrix was detected in the culture dish by alcian blue staining or von-Kossa silver impregnation. MCO-Y4 cells on the chamber slides showed intense immunoreactivity for BMP-2/4 and BMPR II. Noggin, an antagonist for BMP-2/ 4, showed the growth inhibition on MCO-Y4 cells. In addition, fibronectin might be potential for stimulating growth of MCO-Y4 cells. When transplanted into severe combined immunodeficiency mice, the cells formed tumors consisting of solid proliferation of osteoblastic and fibroblastic cells with woven-bone trabeculae. These tumor cells were intensely positive for BMP-2/4 and BMPR II. Our results suggested that the cell line might be useful for studying the role of BMPs in canine osteosarcoma and the mechanism of ossification. KEY WORDS: bone morphogenetic protein, canine mammary gland, cell line, noggin, osteosarcoma.

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“…A retrospective study of extraskeletal OSA (OES) in 169 dogs and a comparative evaluation of OSA in dogs and humans described metastasis in lymph nodes, lungs, kidneys, spleen, bone marrow, tegument, but did not mention the brain (9,14). In another study of OSA in 156 dogs, brain metastasis was noticed only in the Rottweiler, what 108 suggests that biological behavior of this breed may be different (12).…”

Section: Discussionmentioning

confidence: 99%

Metastatic osteosarcoma as a cause of hemorrhagic stroke in a dog

Cristo¹,

Vargas²,

Biezus³

et al. 2017

Braz. J. Vet. Pathol.

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Cristo, et al.; Metastatic osteosarcoma as a cause of hemorrhagic stroke in a dog. Braz J Vet Pathol, 2017, 10(3), 105 -110 DOI: 10.24070/bjvp.1983-0246.v10i3p105-110 AbstractThe aim of this case report is to describe an uncommon hemorrhagic cerebrovascular accident (CVA) associated with an osteosarcoma (OSA) metastasis. Cerebrovascular accident (CVA) is the acute onset of a neurological deficit from any change in blood supply resulting from a pathological process, characterizing a stroke and among all the causes, the neoplastic thrombus of osteosarcoma, specifically, is the most infrequent in clinical practice. A seven-year-old female midsize mixed-breed dog was submitted to a forelimb amputation for showing an osteoblastic OSA in proximal humerus. Three weeks later, the patient presented uninterruptible seizure and coma, resulting in death. At necropsy, it was observed a friable and reddish mass in the left frontal cortex which, microscopically was constituted by OSA metastasis in association with multiple ruptures of blood vessels and focally extensive severe bleeding, which caused a CVA. At immunohistochemistry, neoplastic cells of the humerus and the brain metastasis were positive for vimentin and osteonectin, confirming the diagnosis of osteoblastic OSA. The reports about OSA metastasis on the brain are rare in animals and humans, what could be related to the low frequency and few diagnosis ante and post-mortem. As uncommon as the description of OSA metastasis to the brain, is the CVA associated to them, demonstrating that reporting cases related to these clinical and anatomopathological lesions are important for the scientific community.

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Extraskeletal osteosarcomas in dogs: a retrospective study of 169 cases (1986-1996)

Cited by 102 publications

References 12 publications

The animal-dependent risk factors in canine osteosarcomas

The animal-dependent risk factors in canine osteosarcomas

Establishment and Characterization of a Cell Line, MCO-Y4, Derived from Canine Mammary Gland Osteosarcoma

Metastatic osteosarcoma as a cause of hemorrhagic stroke in a dog

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