Extraskeletal risk factors for fractures of the proximal femur

Lefauveau, Pascal; Fardellone, Patrice

doi:10.1016/s1297-319x(03)00140-4

Cited by 11 publications

(7 citation statements)

References 33 publications

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“…This number is expected to increase to 2.6 million in 2025 and 4.5 million in 2050, mainly as a consequence of population aging [1]. Hip fractures mainly affect the elderly, especially women [2, 3]. In general, hip fractures have significant consequences on individuals and health-care systems [2].…”

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confidence: 99%

“…Hip fractures mainly affect the elderly, especially women [2, 3]. In general, hip fractures have significant consequences on individuals and health-care systems [2]. They are an important source of morbidity and mortality: 20–30 % of hip fracture patients die within 1 year after the fracture, and one-third are totally dependent or reside in a nursing home after 1 year [4, 5].…”

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confidence: 99%

“…They are an important source of morbidity and mortality: 20–30 % of hip fracture patients die within 1 year after the fracture, and one-third are totally dependent or reside in a nursing home after 1 year [4, 5]. Hip fractures can also cause high managements costs; costs of one hip fracture are estimated at US$21,000 in the first year after surgery [2, 5, 6]. …”

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Potential Impact of Benzodiazepine Use on the Rate of Hip Fractures in Five Large European Countries and the United States

et al. 2012

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Benzodiazepine use increases the risk of falls and has been associated with an increased risk of hip fractures. Our aim was to estimate the possible population impact of the use of benzodiazepines on the rate of hip fracture in France, Germany, Italy, Spain, the United Kingdom, and the United States. We conducted a literature review to estimate the pooled relative risk (RR) for hip fractures and use of benzodiazepines. Prevalence rates of benzodiazepine use in 2009 were calculated for each country using the IMS MIDAS database and three public databases in Denmark, the Netherlands, and Norway. Both the RR and prevalence rates were used for calculation of population attributable risks (PARs) of hip fractures associated with benzodiazepine use. The literature review showed an increased risk of hip fractures in benzodiazepine users (RR = 1.4, 95 % CI 1.2–1.6). Rate of benzodiazepine use showed considerable differences between countries, ranging from 4.7 % to 22.3 % of population ever in a 1-year period. These are reflected in results for the PARs; estimated attributions of benzodiazepines to the rate of hip fractures were 1.8 %, 95 % CI 1.1–2.6 (Germany); 2.0 %, 95 % CI 1.2–2.8 (United Kingdom); 5.2 %, 95 % CI 3.2–7.3 (Italy); 7.4 %, 95 % CI 4.5–10.0 (France); 8.0 %, 95 % CI 4.9–11.0 (United States); and 8.2 %, 95 % CI 5.1–12.0 (Spain). PAR estimates suggest that the potential attribution of benzodiazepine use on the population rate of hip fractures in the five specified European countries and the United States varies between 1.8 % and 8.2 %. During the next phase of the IMI-PROTECT study, a comparison with individual patient data will show whether this approach is valid.

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Potential Impact of Benzodiazepine Use on the Rate of Hip Fractures in Five Large European Countries and the United States

et al. 2012

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“…: +41 residence and cognitive impairment were significant factors that increase the risk factors for hip fractures. Lefauveau [19] presented a review where the role of height, body mass, the reason for falls, age, gender, ethnicity and geographic area of birth as well as physical activity were investigated in connection with fractures of the proximal femur. A further classification of risk factors was given by Woolf et al [20].…”

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confidence: 99%

“…Faulkner and others [38][39][40] reported that the hip axis length (HAL) is a risk factor independent of the BMD and Lochmüller et al [41] confirmed this hypothesis by finding a positive correlation between HAL and femoral strength. Lefauveau et al [19] reported that the femoral neck length was greater in a group of patients who suffered a fracture and that a longer femoral neck increased the odds ratio for true neck fractures, but not for trochanteric fractures. Center et al [42] found a greater femoral neck width (FNW) in fracture cases than in controls.…”

Section: Introductionmentioning

confidence: 99%