Extrauterine low‐grade endometrial stromal sarcoma: Report of three cases

Fukunaga, Masao; Ishihara, Akira; Ushigome, Shinichiro

doi:10.1111/j.1440-1827.1998.tb03909.x

Cited by 51 publications

(29 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, it is reasonable to suggest that ESS arising from endometriosis should be considered in the differential diagnosis of a pelvic mass in patients with highly elevated CA125 levels together with a history of endometriosis. Nevertheless, data with regard to serum CA125 levels in patients with ESS arising from endometriosis are limited and are currently only available in 7 published case reports [2,24,29,30,31,35,37]. More studies to estimate the value of the CA125 level in ESS arising from endometriosis are warranted.…”

Section: Discussionmentioning

confidence: 99%

“…However, ESS arising from endometriosis is a rarer disease with an incompletely understood etiology. Previous studies have usually been based on case reports, and no more than 50 cases of ESS arising in endometriosis have been reported in the English literature (table 3) [2,4,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37]. In the current study, we reported the clinicopathological features of a series of 5 cases treated in our center, including the results of expression analyses for several possible markers for targeted therapy.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Endometrial Stromal Sarcoma Arising from Endometriosis: A Clinicopathological Study and Literature Review

Lan¹,

Huang²,

Lin³

et al. 2012

Gynecol Obstet Invest

View full text Add to dashboard Cite

Objectives: We aimed to investigate the nature of endometrial stromal sarcoma (ESS) arising from endometriosis. Methods: The clinical data of 5 patients with ESS arising from endometriosis were reviewed retrospectively. The expression of CD117, HER2/neu, EGFR, VEGF, and PDGFR was analyzed by immunohistochemical staining. Results: The median age of the 5 patients was 45 years. The primary tumor sites were the ovary in 2, the pelvis in 2, and the cervical canal in 1 patient. Three patients had disseminated disease at diagnosis. Four patients underwent complete tumor resection. All of the 5 cases received adjuvant chemotherapy and 2 received progesterone therapy, while none were treated with radiotherapy. No recurrence occurred in the 4 cases who had complete tumor resection, and the only patient who progressed was the patient in whom the tumor was unresectable. Tumor cells in all cases exhibited positive staining for PDGFR and were negative for CD117 and HER2/neu. The expression of EGFR and VEGF was observed in 2 and 4 cases, respectively. Conclusion: ESS arising from endometriosis is rare. Complete tumor resection in ESS arising from endometriosis may reduce the recurrence rate.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Endometrial Stromal Sarcoma Arising from Endometriosis: A Clinicopathological Study and Literature Review

Lan¹,

Huang²,

Lin³

et al. 2012

Gynecol Obstet Invest

View full text Add to dashboard Cite

show abstract

“…There is an association between hormonal therapy, especially unopposed estrogens, and the development of ESS (and other neoplasms) in endometriosis. [39][40][41] Unopposed estrogens are contraindicated in post-hysterectomy patients with a history of endometriosis. Before making a diagnosis of a primary ovarian (or any extrauterine) ESS, a primary uterine neoplasm should be excluded.…”

Section: Ovarian Endometrial Stromal Sarcomamentioning

confidence: 99%

Ovarian Neoplasms Composed of Small Round Cells

McCluggage¹

2004

Advances in Anatomic Pathology

102

View full text Add to dashboard Cite

Ovarian neoplasms composed predominantly or exclusively of small round cells with scant cytoplasm are relatively rare. However, there is a wide differential, and pathologists often struggle to make a correct diagnosis because of overlapping histologic features. Perhaps the best known of these neoplasms is ovarian small cell carcinoma of hypercalcemic type (OSCCHT), a tumor of unknown histogenesis. This may be confused with a wide range of neoplasms ranging from sex cord-stromal tumors (some of which may exhibit a small cell phenotype) to neoplasms in the family of small round blue cell tumors to various undifferentiated malignancies. A neuroendocrine small cell carcinoma, so-called small cell carcinoma of pulmonary type, may also arise within the ovary, and this may be a component of a typical ovarian surface epithelial-stromal tumor. In addition to the well-known family of small round blue cell tumors of childhood, other small cell neoplasms that may arise within the ovary or involve the ovary include intra-abdominal desmoplastic small round cell tumor, metastatic small cell carcinoma, peripheral and central primitive neuroectodermal tumor, and endometrial stromal sarcoma. Malignant melanoma, undifferentiated carcinoma, and various germ cell tumors, especially dysgerminoma and immature teratoma, also on occasion enter into the differential diagnosis of an ovarian small cell neoplasm. In this review, the morphologic features of some of these neoplasms are described, as is the value of immunohistochemistry and other ancillary techniques in establishing a diagnosis.

show abstract

“…30 ESS is more common in extraovarian endometriosis than in ovarian lesions, possibly reflecting the increased hormone sensitivity of the pelvic peritoneum vs. the ovary. 31,32 This finding could also reflect the tissue preference of cells.…”

Section: Histology Of Endometriosis-related Malignant Conditionsmentioning

confidence: 99%

Ovarian endometriosis as a premalignant condition: epidemiological, histological and molecular evidence

Dreyer

2012

Southern African Journal of Gynaecological Oncology

View full text Add to dashboard Cite

Endometriosis is a common monoclonal benign proliferative disorder that may give rise to pelvic malignancy. Epithelial ovarian carcinoma is responsible for a large proportion of gynaecological cancer-associated deaths. Early diagnosis is difficult and screening is generally unsuccessful. Knowledge of the risk factors for the development of endometriosis and progression to malignancy may assist in identifying women at risk of developing endometriosis-related neoplasia. The associations between infertility, endometriosis and the development of cancer are reviewed in this article. Proliferative growth, metaplasia, hyperplasia and atypia are identified as proliferative disorders in endometriosis and atypia is considered a premalignant lesion. Several endometriosis-related pelvic malignancies have been described, and these all develop from the multipotent Müllerian cell differentiating into epithelial and/or stromal components. The probable histological type depends on the site of the endometriotic lesion and the population group. Cytogenetic and specific gene alterations that are involved in the carcinogenetic process are described briefly and these may help to predict risk of malignancy or to confirm histological subtype. The importance of endometriosis as a precursor of ovarian and related malignancies was probably seriously underestimated in the past. Advances in molecular testing, histology and our understanding of oncogenesis may empower us to help prevent these devastating diseases.Peer reviewed.

show abstract

Extrauterine low‐grade endometrial stromal sarcoma: Report of three cases

Cited by 51 publications

References 15 publications

Endometrial Stromal Sarcoma Arising from Endometriosis: A Clinicopathological Study and Literature Review

Endometrial Stromal Sarcoma Arising from Endometriosis: A Clinicopathological Study and Literature Review

Ovarian Neoplasms Composed of Small Round Cells

Ovarian endometriosis as a premalignant condition: epidemiological, histological and molecular evidence

Contact Info

Product

Resources

About