Extravasation of Antineoplastic Agents: Prevention And Treatments

Boschi, Rita; Rostagno, Elena

doi:10.4081/pr.2012.e28

Cited by 25 publications

(20 citation statements)

References 18 publications

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“…The repetitive nature of this process impairs healing and may result in progressive and chronic tissue injury. Second, the drug that does not bind to cellular DNA may metabolize and be cleared, limiting the degree of tissue injury [ 21 ]. However, the literature addressing extravasation is limited to animal studies, case reports, and small human studies.…”

Section: Adverse Effects Of Anticancer Drugsmentioning

confidence: 99%

Development of Newly Synthesized Chromone Derivatives with High Tumor Specificity against Human Oral Squamous Cell Carcinoma

et al. 2020

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Since many anticancer drugs show severe adverse effects such as mucositis, peripheral neurotoxicity, and extravasation, it was crucial to explore new compounds with much reduced adverse effects. Comprehensive investigation with human malignant and nonmalignant cells demonstrated that derivatives of chromone, back-bone structure of flavonoid, showed much higher tumor specificity as compared with three major polyphenols in the natural kingdom, such as lignin-carbohydrate complex, tannin, and flavonoid. A total 291 newly synthesized compounds of 17 groups (consisting of 12 chromones, 2 esters, and 3 amides) gave a wide range of the intensity of tumor specificity, possibly reflecting the fitness for the optimal 3D structure and electric state. Among them, 7-methoxy-3-[(1E)-2-phenylethenyl]-4H-1-benzopyran-4-one (compound 22), which belongs to 3-styrylchromones, showed the highest tumor specificity. 22 induced subG1 and G2 + M cell population in human oral squamous cell carcinoma cell line, with much less keratinocyte toxicity as compared with doxorubicin and 5-FU. However, 12 active compounds selected did not necessarily induce apoptosis and mitotic arrest. This compound can be used as a lead compound to manufacture more active compound.

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Section: Adverse Effects Of Anticancer Drugsmentioning

confidence: 99%

Development of Newly Synthesized Chromone Derivatives with High Tumor Specificity against Human Oral Squamous Cell Carcinoma

et al. 2020

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“…Areas with limited soft tissue to protect underlying structures (tendons, bones and nerves) and areas with small and fragile veins, such as lower extremities, should be avoided 8 9. European Society for Medical Oncology guidelines advise using large veins in the forearm and against using sites over joints, the inner wrist, lower extremities, antecubital fossa or on the dorsum of the hand 1.…”

Section: Discussionmentioning

confidence: 99%

Epirubicin extravasation: consequences of delayed management

Hale

Deutsch²,

Lahiri

2017

BMJ Case Reports

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Epirubicin is an anthracycline chemotherapy agent used for treatment of several cancers including oesophageal, breast and gastric. Extravasation is a well-recognised and serious complication of any intravenous therapies but especially chemotherapeutic agents. Signs of the injury can be subtle and without prompt recognition and treatment there can be extensive tissue damage and depending on location of injury this can result in significant functional loss. In this article, a case of delayed management of epirubicin extravasation from a cannula situated at the dorsum of the hand is discussed. Successful surgical reconstruction of the resulting substantial tissue damage using a radial forearm flap 21 days following injury is described.

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“…Irritants do not typically cause soft tissue ulcers unless a large quantity of the drug is inadvertently extravasated ( Ener et al, 2004 ). Extravasation is the accidental direct infiltration of chemotherapy into the tissues surrounding the intravenous site ( Boschi and Rostagno, 2012 ). Extravasation of anti-neoplastic agents can potentially cause tissue necrosis and functional impairment ( Boschi and Rostagno, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

“…Extravasation is the accidental direct infiltration of chemotherapy into the tissues surrounding the intravenous site ( Boschi and Rostagno, 2012 ). Extravasation of anti-neoplastic agents can potentially cause tissue necrosis and functional impairment ( Boschi and Rostagno, 2012 ).…”

Section: Introductionmentioning

confidence: 99%