Extraventricular unusual glioma in a child with extensive myxoid change resembling chordoid glioma

Goyal, Renu; Vashishta, Rakesh Kumar; Singhi, Samata; Gill, Manmeet Kaur

doi:10.1136/jcp.2005.033548

Cited by 17 publications

(23 citation statements)

References 11 publications

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“…[23, 26] Intratumoral hemorrhage was noted in 3 patients. [5, 15, 27] Heterogenous enhancement was noted in 3 patients [6, 28], and includes the present case.…”

Section: Resultssupporting

confidence: 58%

“…Four patients died from pulmonary embolism postoperatively[1, 7, 20, 24], 4 from infectious causes [6, 9, 26, 40], two from myocardial infarction. [5, 21] No deaths from tumor progression were reported in any study. Age, tumor size, MIB, EOR, and RT did not predict survival.…”

Section: Resultsmentioning

confidence: 99%

“…[5, 7, 18, 37] Cells are typically found within a mucinous vacuolated stroma. [5, 7, 18, 37] Tumor immunopositivity for GFAP, EMA, CD34, cytokeratin, S100, and vimentin is commonly present. [5, 11, 38–40] Some degree of lymphocytic infiltrate appears to be common.…”

Section: Resultsmentioning

confidence: 99%

“…[5, 7, 18, 37] Tumor immunopositivity for GFAP, EMA, CD34, cytokeratin, S100, and vimentin is commonly present. [5, 11, 38–40] Some degree of lymphocytic infiltrate appears to be common. Of the 57 cases that elaborated on extent of lymphocyte infiltration, 4 reported sparse infiltrate (7.0%).…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Prognostic factors for recurrence and complications in the surgical management of primary chordoid gliomas: A systematic review of literature

Ampie

Choy

Lamano

et al. 2015

Clinical Neurology and Neurosurgery

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Introduction Chordoid Gliomas (CG) are rare neoplasms which frequently arise within the third ventricle. Surgery remains the mainstay treatment for CG. The present study comprehensively reviews all reported cases of CG within the literature in order to identify risk factors for surgical complications and tumor recurrence. Methods A comprehensive search on MEDLINE (OVID and Pubmed), Scopus, Embase, and Web of Science was conducted following PRISMA guidelines to identify all reported cases of CG. Results A total of 81 patients met the study criteria, comprised of 33 males and 48 females. Median age at diagnosis was 48 years with a range from 5 to 72 years, and mean tumor size was 3.1 cm. Biopsy, subtotal resection (STR), and gross total resection (GTR) was achieved in 8, 34, and 33 patients, respectively, with 6 cases not reporting extent of eresection (EOR). Thirteen patients underwent adjuvant radiotherapy. Postoperative complications were noted in 30 cases (37%), with new onset diabetes insipidus being the most common. Postoperative morbidity was not associated with age, tumor size, or extent of resection. A trans-lamina terminalis approach demonstrated a strong trend towards decreased overall rates of postoperative morbidity compared to other approaches (p=0.051). GTR was associated with improved progression-free survival (PFS; p=0.028), while adjuvant radiotherapy, age, tumor size and MIB-I were not predictive of patient outcomes. Conclusion GTR should be the primary goal for the management of CG, as it is associated with improved rates of tumor control without an increased rate of postoperative complications. Surgical approach was a stronger predictor of complication rates than extent of resection. Morbidity remains high, and future studies to further elaborate on factors predictive of postoperative complications are critical.

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“…[23, 26] Intratumoral hemorrhage was noted in 3 patients. [5, 15, 27] Heterogenous enhancement was noted in 3 patients [6, 28], and includes the present case.…”

Section: Resultssupporting

confidence: 58%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic factors for recurrence and complications in the surgical management of primary chordoid gliomas: A systematic review of literature

Ampie

Choy

Lamano

et al. 2015

Clinical Neurology and Neurosurgery

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“…20) The ideal treatment for chordoid glioma would be GTR without complications, but this is quite difficult because of the size and location of the tumor. 8,13,17,27,31) PR can reduce the tumor volume and also increase the distance from the optic pathways, where the risk of morbidity could be minimized while the effect of gamma knife radiosurgery is maximized. Less invasive microsurgery and gamma knife radiosurgery with a lower marginal dose can provide a safe and effective treatment for chordoid glioma of the third ventricle.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Approach to Chordoid Glioma of the Third Ventricle

Kobayashi

Tsugawa

Hashizume

et al. 2013

Neurol. Med. Chir.(Tokyo)

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Chordoid glioma of the third ventricle is considered to be a benign glial tumor located exclusively in the mid-anterior portion of the third ventricle near the hypothalamus and optic nerves, with the histological features of a chordoma and immuno-labeling for glial fibrillary acidic protein. Unfortunately, the clinical outcome of chordoid glioma has been poor, even in patients receiving gross total or partial removal with or without radiotherapy. Three cases of chordoid glioma of the third ventricle were treated with less invasive microsurgery for pathological diagnosis or partial removal without neuro-endocrinological complication, followed by gamma knife radiosurgery using a lower marginal dose for the optic nerves and hypothalamus. Gamma knife radiosurgery was performed after open biopsy in two patients, and after partial removal in the third patient using a lower marginal dose of 10.5 to 12 Gy. Serial magnetic resonance imaging revealed gradual decrease or at least no change in the tumor size, without significant complication at follow up 70 and 66 months later in two cases. The third patient accidentally died 13 months after gamma knife treatment. We conclude that low dose gamma knife radiosurgery after less invasive microsurgery is both safe and effective for the control of chordoid glioma of the third ventricle over a very long follow-up period.

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Assessment of magnetic resonance imaging and histopathological changes in chordoid glioma: A retrospective analysis of 13 cases

Huang,

Deng,

Wen

et al. 2024

Int J Imaging Syst Tech

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Chordoid glioma (CG) is a rare tumor, and its predominantly anterior location is in the third ventricle. However, the clinical characteristics of CG were not obvious, and there was less knowledge of CG‐related imaging. This study aimed at exploring the MRI imaging features of CG. We retrospectively analyzed the MRI data of 13 patients diagnosed with CG from January 2015 to May 2021. The pathological change of tumor tissue was observed using H&E staining and immunohistochemical. The MRI manifestations of CG often include phyllode masses in the anterior part of the third ventricle. T2WI is dominated by iso‐ and hypointensity, with internal patchy hyperintensity, marked enhancement, and peritumoral edema. The “eight‐character edema sign” runs along the optic beam and may be useful for distinguishing CG from other tumors. CG has unique MRI manifestations that can serve as a diagnostic basis. Our study may help to enhance the understanding of imaging about CG and improve the diagnosis of patients with CG.

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Extraventricular unusual glioma in a child with extensive myxoid change resembling chordoid glioma

Cited by 17 publications

References 11 publications

Prognostic factors for recurrence and complications in the surgical management of primary chordoid gliomas: A systematic review of literature

Prognostic factors for recurrence and complications in the surgical management of primary chordoid gliomas: A systematic review of literature

Therapeutic Approach to Chordoid Glioma of the Third Ventricle

Assessment of magnetic resonance imaging and histopathological changes in chordoid glioma: A retrospective analysis of 13 cases

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