Extravillous trophoblast invasion of venous as well as lymphatic vessels is altered in idiopathic, recurrent, spontaneous abortions

Windsperger, Karin; Dekan, Sabine; Pils, Sophie; Golletz, Carsten; Kunihs, Victoria; Fiala, Christian; Kristiansen, Glen; Knöfler, Martin; Pollheimer, Jürgen

doi:10.1093/humrep/dex058

Cited by 99 publications

(98 citation statements)

References 35 publications

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“…In both cases, it will be interesting to see whether endolymphatic trophoblasts can be retrieved from local lymph nodes. The first data showing a respective localization have already been published [26].…”

Section: Endolymphatic Trophoblastmentioning

confidence: 99%

“…At the same time, the remaining secretion products and the respective fluids need to be drained back into the maternal system. Hence, erosion and connection of uterine veins to the intervillous space of the placenta needs to take place next ( Figure 2A) [24][25][26]. Other images of the Enders collection show the junctional zone of trophoblast invasion at the secondary villus stage.…”

Section: Looking Into Invaded Uterine Structures From the Embryo's Numentioning

confidence: 99%

“…Following invasion into uterine glands, it seems as if the next route of invasion guides extravillous trophoblasts toward uterine veins (Figure 2A) [24][25][26]. The secretion products of the uterine glands need to be removed from the growing intervillous space.…”

Section: Endovenous Trophoblastmentioning

confidence: 99%

“…Finally, invasion into uterine lymph vessels is described (endolymphatic trophoblast) [24,26]. The function of this route of invasion is unclear so far.…”

Section: Endolymphatic Trophoblastmentioning

confidence: 99%

“…In cases with idiopathic recurrent spontaneous abortion, a role for alterations of trophoblast invasion into spiral arteries has been described; however, this role is still debated today, with no final conclusion whether or not there is a direct relation between altered arterial invasion and the etiology of recurrent spontaneous abortion [35][36][37]. Windsperger et al (2017) [26] recently analyzed decidual placental bed tissues from cases with recurrent spontaneous abortion. These authors quantified the spatial distribution of extravillous trophoblasts in placental bed spiral arteries, veins, and lymph vessels.…”

Section: One Example Of Non-arterial Changes Of Trophoblast Invasion mentioning

confidence: 99%

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Traditional and New Routes of Trophoblast Invasion and Their Implications for Pregnancy Diseases

Huppertz

2019

IJMS

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Historically, invasion of placental trophoblasts was thought to be extremely specific, only invading into the connective tissues of the maternal uterus and finally reaching and transforming the uterine spiral arteries. Only recently, identification of new routes of trophoblast invasion into different structures of the maternal uterus has been achieved. Thorough morphological analysis has resulted in the identification of trophoblasts invading into glands, veins, and lymph vessels of the uterine wall. These new routes pave the way for a re-evaluation of trophoblast invasion during normal placental development. Of course, such new routes of trophoblast invasion may well be altered, especially in pregnancy pathologies such as intra-uterine growth restriction, preeclampsia, early and recurrent pregnancy loss, stillbirth, and spontaneous abortion. Maybe one or more of these pregnancy pathologies show alterations in different pathways of trophoblast invasion, and, thus, etiologies may need to be redefined, and new therapies may be developed.

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Section: Endolymphatic Trophoblastmentioning

confidence: 99%

Section: Looking Into Invaded Uterine Structures From the Embryo's Numentioning

confidence: 99%

Section: Endovenous Trophoblastmentioning

confidence: 99%

“…Finally, invasion into uterine lymph vessels is described (endolymphatic trophoblast) [24,26]. The function of this route of invasion is unclear so far.…”

Section: Endolymphatic Trophoblastmentioning

confidence: 99%