Extreme duration exercise affects old and younger men differently

Abstract

Aim & Methods: Extreme endurance exercise provides a valuable research model for understanding the adaptive metabolic response of older and younger individuals to intense physical activity. Here, we compare a wide range of metabolic and physiologic parameters in two cohorts of seven trained men, age 30 ± 5 years or age 65 ± 6 years, before and after the participants travelled ≈3000 km by bicycle over 15 days. Results: Over the 15-day exercise intervention, participants lost 2-3 kg fat mass with no significant change in body weight. VȮ 2 max did not change in younger cyclists, but decreased (p = 0.06) in the older cohort. The resting plasma FFA concentration decreased markedly in both groups, and plasma glucose increased See related editorial: Henriksson J. 2022. Extreme duration endurance exercise affects old and younger men differently-Older individuals experience a negative adaptive response affecting cardiovascular function. Acta Physiol (Oxf). e13843.

Preponderant Myosin Super-Relaxed State In Skeletal Muscle From Endurance Athletes

“…This study utilized four distinct groups, each with vastly different physical training profiles, several of which have been used in studies published previously (Hokken et al, 2021, Frandsen et al, 2022, Sahl et al, 2018). Age, height, weight, and body mass index (BMI) for all four groups as well as max values for physically active controls and endurance athletes are presented in Table 1.…”

“…Two contrasting athlete groups were recruited, comprising endurance athletes (EA) and strength athletes (SA). EA subjects were recruited from lo-cal groups of very highly-trained endurance cyclists ( 63.0 ± 3.4 mL/kg/min training load 9.1 ± 3.7 h/week) (table 1) (Frandsen et al, 2022). SA subjects were recruited from local weight training clubs.…”

“…For EA was assessed with breath-by-breath measurements of pulmonary and by an online system (COSMED Quark CPET, COSMED, Italy) during a graded exercise test performed on a cycle ergometer. The protocol was adapted from the Achten 35/3 protocol and described in detail elsewhere (Achten et al, 2002, Frandsen et al, 2022). In brief, the protocol was performed in continuation of a submaximal graded exercise test for determination of substrate oxidation, and was elicited through workload increments of 35 W every minute until volitional exhaustion.…”

The new impact factor for Acta physiologica: Rising high in the field of physiology

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Exercise and energy

“…Research has recently focussed on, for example, the differential effects of exercise in subjects of different age groups 4,5 and the beneficial effects of endurance exercise on pathologies associated with an aging population, e.g. neuromuscular degenerative diseases 6 and type 2 diabetes 7 .…”