Extreme genetic heterogeneity among the nine major tribal Taiwanese island populations detected with a new generation Y23 STR system

Zeng, Zhaoshu; Garcia-Bertrand, Ralph; Calderon, Silvia; Li, Li; Zhong, Mingxia; Herrera, René J.

doi:10.1016/j.fsigen.2014.05.004

Cited by 10 publications

(10 citation statements)

References 17 publications

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“…For example, the Atayal appeared to have a remote relationship with the other populations on the basis of our results. Previous population genetic analyses consistently revealed similar genetic variations, which may result from numerous factors, such as socio-cultural characteristics (i.e., endogamy, language barriers), and the emergence of a high aggregation of specific haplotype [7,10].…”

Section: Discussionmentioning

confidence: 77%

Phylogenetic analysis and forensic characteristics of 12 populations using 23 Y-STR loci

Gao

Yun

et al. 2015

Forensic Science International: Genetics

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Section: Discussionmentioning

confidence: 77%

Phylogenetic analysis and forensic characteristics of 12 populations using 23 Y-STR loci

Gao

Yun

et al. 2015

Forensic Science International: Genetics

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“…Small sample sizes can inflate the genetic distances, and with just 20 sampled individuals from each group, the R ST values should be interpreted with caution. However, we note that such extreme genetic distances have been observed previously between other ethnic groups living in relative geographic proximity, when they have experienced prolonged and severe genetic isolation coupled with long‐standing endogamy (Zeng et al., ; Roewer et al., ; Gaikwad et al., ). As such, it is perhaps not unexpected to observe large genetic distances between the ethnic groups of Swat and Dir districts given their isolated residential localities, their cultural preferences for endogamous marriages, as well as their differences in subsistence practices, lifestyles, and language (Barth, ).…”

Section: Discussionmentioning

confidence: 82%

High Y‐chromosomal Differentiation Among Ethnic Groups of Dir and Swat Districts, Pakistan

Ullah

Olofsson

Ilardo

et al. 2017

Annals of Human Genetics

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The ethnic groups that inhabit the mountainous Dir and Swat districts of northern Pakistan are marked by high levels of cultural and phenotypic diversity. To obtain knowledge of the extent of genetic diversity in this region, we investigated Y-chromosomal diversity in five population samples representing the three main ethnic groups residing within these districts, including Gujars, Pashtuns and Kohistanis. A total of 27 Y-chromosomal short tandem repeats (Y-STRs) and 331 Y-chromosomal single nucleotide polymorphisms (Y-SNPs) were investigated. In the Y-STRs, we observed very high and significant levels of genetic differentiation in nine of the 10 pairwise between-group comparisons (R 0.179-0.746), and the differences were mirrored in the Y-SNP haplogroup frequency distribution. No genetic differences were found between the two Pashtun subethnic groups Tarklanis and Yusafzais (R = 0.000). Utmankhels, also considered Pashtuns culturally, were not closely related to any of the other population samples (R 0.451-0.746). Thus, our findings provide examples of both associations and dissociations between cultural and genetic legacies. When analyzed within a larger continental-scale context, these five ethnic groups fall mostly outside the previously characterized Y-chromosomal gene pools of the Indo-Pakistani subcontinent. Male founder effects, coupled with culturally and topographically based constraints upon marriage and movement, are likely responsible for the high degree of genetic structure in this region.

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“…Attentions have been paid to demonstrating the inner-population structure utilizing Y-STRs as genetic markers for the purpose of inferring the most likely geographic origin of a haplotype at Y chromosome. In 2014, Zeng et al [27] discussed the Taiwanese origin of the Austronesian expansion within 9 major aboriginal tribes inhabiting Taiwan. And in 2016, Ulises et al [29] reported a comprehensive study on population structure of 13 Argentine provinces.…”

Section: Resultsmentioning

confidence: 99%

“…And we got the allele of DYS389II by the subtraction of DYS389I. The popular combination of computational R ST values which referred to the excess similarity among alleles chosen randomly within the subgroup relative to the entire group [25] and Multidimensional Scaling plot (MDS) [26] was adopted as YHRD analyzed and many publications conducted [15,19,27–32]. Linkage patterns and Analysis of Molecular Variance (AMOVA) which generated the pairwise R ST values and according significant values were performed using Arlequin 3.0 based on detailed haplotype information of eligible individuals (samples with the null, intermediate alleles, and copy-number variations were removed).…”

Section: Methodsmentioning

confidence: 99%

Inner and inter population structure construction of Chinese Jiangsu Han population based on Y23 STR system

HuiPin¹,

Ba²,

Yang³

et al. 2017

PLoS ONE

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In this study, we analyzed the genetic polymorphisms of 23 Y-STR loci from PowerPlex® Y23 system in 916 unrelated healthy male individuals from Chinese Jiangsu Han, and observed 912 different haplotypes including 908 unique haplotypes and 4 duplicate haplotypes. The haplotype diversity reached 0.99999 and the discrimination capacity and match probability were 0.9956 and 0.0011, respectively. The gene diversity values ranged from 0.3942 at DYS438 to 0.9607 at DYS385a/b. Population differentiation within 10 Jiangsu Han subpopulations were evaluated by RST values and visualized in Neighbor-Joining trees and Multi-Dimensional Scaling plots as well as population relationships between the Jiangsu Han population and other 18 Eastern Asian populations. Such results indicated that the 23 Y-STR loci were highly polymorphic in Jiangsu Han population and played crucial roles in forensic application as well as population genetics. For the first time, we reported the genetic diversity of male lineages in Jiangsu Han population at a high-resolution level of 23 Y-STR set and consequently contributed to familial searching, offender tracking, and anthropology analysis of Jiangsu Han population.

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Extreme genetic heterogeneity among the nine major tribal Taiwanese island populations detected with a new generation Y23 STR system

Cited by 10 publications

References 17 publications

Phylogenetic analysis and forensic characteristics of 12 populations using 23 Y-STR loci

Phylogenetic analysis and forensic characteristics of 12 populations using 23 Y-STR loci

High Y‐chromosomal Differentiation Among Ethnic Groups of Dir and Swat Districts, Pakistan

Inner and inter population structure construction of Chinese Jiangsu Han population based on Y23 STR system

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