Extremely high prevalence of multidrug resistant tuberculosis in Murmansk, Russia: a population-based study

Mäkinen, Johanna; Marjamäki, Merja; Haanperä-Heikkinen, M.; Marttila, Harri; Endourova, L. B.; Преснова, С. Э.; Mathys, Vanessa; Bifani, Pablo; Ruohonen, R.; Viljanen, Matti K.; Soini, Hanna

doi:10.1007/s10096-011-1200-7

Cited by 25 publications

(18 citation statements)

References 30 publications

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“…Beijing family was the predominant genotype among the 58 XDR-TB isolates, correlating with reports from Beijing [7] and other regions of the world [4,28,29]. The modern Beijing sublineage constituted the majority (70.5%) of Beijing family strains.…”

Section: Discussionsupporting

confidence: 69%

Molecular characterisation of extensively drug-resistant Mycobacterium tuberculosis isolates in China

Zhao

Sun

Zeng

et al. 2015

International Journal of Antimicrobial Agents

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Section: Discussionsupporting

confidence: 69%

Molecular characterisation of extensively drug-resistant Mycobacterium tuberculosis isolates in China

Zhao

Sun

Zeng

et al. 2015

International Journal of Antimicrobial Agents

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“…Studies in Russia (54) and Ukraine (55) found that rpoB531 was highly prevalent in strains of the Beijing genotype. In contrast, we found no significant association between the genotype and any resistance-conferring mutation, including rpoB531.…”

Section: Discussionmentioning

confidence: 99%

Molecular Characterization of Multidrug-Resistant Mycobacterium tuberculosis Isolates from China

Zhao

Chen

Liu

et al. 2014

Antimicrob Agents Chemother

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eTo investigate the molecular characterization of multidrug-resistant tuberculosis (MDR-TB) isolates from China and the association of specific mutations conferring drug resistance with strains of different genotypes, we performed spoligotyping and sequenced nine loci (katG, inhA, the oxyR-ahpC intergenic region, rpoB, tlyA, eis, rrs, gyrA, and gyrB) for 128 MDR-TB isolates. Our results showed that 108 isolates (84.4%) were Beijing family strains, 64 (59.3%) of which were identified as modern Beijing strains. Compared with the phenotypic data, the sensitivity and specificity of DNA sequencing were 89.1% and 100.0%, respectively, for isoniazid (INH) resistance, 93.8% and 100.0% for rifampin (RIF) resistance, 60.0% and 99.4% for capreomycin (CAP) resistance, 84.6% and 99.4% for kanamycin (KAN) resistance, and 90.0% and 100.0% for ofloxacin (OFX) resistance. The most prevalent mutations among the MDR-TB isolates were katG315, inhA15, rpoB531, -526, and -516, rrs1401, eis-10, and gyrA94, -90, and -91. Furthermore, there was no association between specific resistance-conferring mutations and the strain genotype. These findings will be helpful for the establishment of rapid molecular diagnostic methods to be implemented in China.

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“…In particular, a 74.8% rate of prevalence of the Beijing family in the studied population was found (compared to an average 50% rate among pulmonary TB patients across Russia [16,27,[36][37][38][39][40][41][42][43][44][45][46][47][48]). At the same time, the rate of B0/W148 in the Beijing population was 30% (35).…”

Section: Virulence and Transmissibilitymentioning

confidence: 99%

Insights into the Origin, Emergence, and Current Spread of a Successful Russian Clone of Mycobacterium tuberculosis

Mokrousov

2013

Clin Microbiol Rev

103

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SUMMARY Mycobacterium tuberculosis variant Beijing B0/W148 is regarded as a successful clone of M. tuberculosis that is widespread in the former Soviet Union and respective immigrant communities. Understanding the pathobiology and phylogeography of this notorious strain may help to clarify its origin and evolutionary history and the driving forces behind its emergence and current dissemination. I present the first review and analysis of all available data on the subject. In spite of the common perception of the omnipresence of B0/W148 across post-Soviet countries, its geographic distribution shows a peculiar clinal gradient. Its frequency peaks in Siberian Russia and, to a lesser extent, in the European part of the former Soviet Union. In contrast, the frequency of B0/W148 is sharply decreased in the Asian part of the former Soviet Union, and it is absent in autochthonous populations elsewhere in the world. Placing the molecular, clinical, and epidemiological features in a broad historical, demographic, and ecological context, I put forward two interdependent hypotheses. First, B0/W148 likely originated in Siberia, and its primary dispersal was driven by a massive population outflow from Siberia to European Russia in the 1960s to 1980s. Second, a historically recent, phylogenetically demonstrated successful dissemination of the Beijing B0/W148 strain was triggered by the advent and wide use of modern antituberculosis (anti-TB) drugs and was due to the remarkable capacity of this strain to acquire drug resistance. In contrast, there is some indication, but not yet systematic proof, of an enhanced virulence of this strain.

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Extremely high prevalence of multidrug resistant tuberculosis in Murmansk, Russia: a population-based study

Abstract: Drug resistance and molecular epidemiology of tuberculosis (TB)

Cited by 25 publications

References 30 publications

Molecular characterisation of extensively drug-resistant Mycobacterium tuberculosis isolates in China

Molecular characterisation of extensively drug-resistant Mycobacterium tuberculosis isolates in China

Molecular Characterization of Multidrug-Resistant Mycobacterium tuberculosis Isolates from China

Insights into the Origin, Emergence, and Current Spread of a Successful Russian Clone of Mycobacterium tuberculosis

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