Extremely low-frequency electromagnetic fields: A possible non-invasive therapeutic tool for spinal cord injury rehabilitation

Kumar, Suneel; Dey, Soumil; Jain, Suman

doi:10.1080/15368378.2016.1194290

Cited by 10 publications

(10 citation statements)

References 147 publications

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“…ELF-EMF therapy has been noted for the minimal level of harm it causes, the extensive range of ways in which it can be used to treat various diseases, as well as the beneficial clinical results achieved with relatively small financial outlay. The nature of the ELF-EMF effect on the body allows deep tissue penetration, however, it is not a thermal method, which makes it possible to use it in the treatment of neurological diseases [17]. ELF-EMF affects the body at both the molecular and cellular level and causes the change in ionic channels.…”

Section: Introductionmentioning

confidence: 99%

Effect of Rehabilitation with Extremely Low Frequency Electromagnetic Field on Molecular Mechanism of Apoptosis in Post-Stroke Patients

et al. 2020

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Apoptosis in acute stroke is associated with a negative prognosis and is correlated with the severity of the neurological deficit. However, there is no evidence that indicates that, in the subacute phase of the stroke, the apoptosis process might activate neuroplasticity. Therefore, in this study, we investigated the effect of an extremely low frequency electromagnetic field (ELF-EMF) on the molecular mechanism of apoptosis, as used in the rehabilitation of post-stroke patients. Patients with moderate stroke severity (n = 48), 3–4 weeks after incident, were enrolled in the analysis and divided into ELF-EMF and non-ELF-EMF group. The rehabilitation program in both groups involves the following: kinesiotherapy—30 min; psychological therapy—15 min; and neurophysiological routines—60 min. Additionally, the ELF-EMF group was exposed to an ELF-EMF (40 Hz, 5 mT). In order to assess the apoptosis gene expression level, we measured the mRNA expression of BAX, BCL-2, CASP8, TNFα, and TP53. We found that ELF-EMF significantly increased the expression of BAX, CASP8, TNFα, and TP53, whereas the BCL-2 mRNA expression after ELF-EMF exposition remained at a comparable level in both groups. Thus, we suggest that increasing the expression of pro-apoptotic genes in post-stroke patients promotes the activation of signaling pathways involved in brain plasticity processes. However, further research is needed to clarify this process.

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Section: Introductionmentioning

confidence: 99%

Effect of Rehabilitation with Extremely Low Frequency Electromagnetic Field on Molecular Mechanism of Apoptosis in Post-Stroke Patients

et al. 2020

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“…Increasing studies have shown that electrical stimulation can guide the neurite growth in vitro and enhance neuron survival and locomotor function improvement of injured spinal cord in vivo (Han et al., 2016b, Hofstoetter et al., 2018, Yao and Li, 2016, Zhang et al., 2017). However, a disadvantage of spinal electrical stimulation is the need for surgery and an implanted electrode array, which may have undesirable effects (Kumar et al., 2017). EA is widely used in clinical practice because of its effectiveness and safety for patients.…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture Facilitates the Integration of Neural Stem Cell-Derived Neural Network with Transected Rat Spinal Cord

et al. 2019

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SummaryThe hostile environment of an injured spinal cord makes it challenging to achieve higher viability in a grafted tissue-engineered neural network used to reconstruct the spinal cord circuit. Here, we investigate whether cell survival and synaptic transmission within an NT-3 and TRKC gene-overexpressing neural stem cell-derived neural network scaffold (NN) transplanted into transected spinal cord could be promoted by electroacupuncture (EA) through improving the microenvironment. Our results showed that EA facilitated the cell survival, neuronal differentiation, and synapse formation of a transplanted NN. Pseudorabies virus tracing demonstrated that EA strengthened synaptic integration of the transplanted NN with the host neural circuit. The combination therapy also promoted axonal regeneration, spinal conductivity, and functional recovery. The findings highlight EA as a potential and safe supplementary therapeutic strategy to reinforce the survival and synaptogenesis of a transplanted NN as a neuronal relay to bridge the two severed ends of an injured spinal cord.

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“…They are commonly used in neurology, psychiatry (treatment of depression), rheumatology, orthopedics (to treat spinal injury) and dermatology both at diagnostic and therapeutic levels ( D’Angelo et al, 2015 , Mattsson and Simkó, 2019 ). ( Kumar et al, 2017 ). It also promotes cell proliferation ( Song et al, 2018 ) and has supporting role of in generating immune-modulatory responses, neuromodulation and possible benefits of neuroprotection.…”

Section: Extremely Low Frequency Radiation (Elf)mentioning

confidence: 99%

Radiobiological effects and medical applications of non-ionizing radiation

Omer

2021

Saudi Journal of Biological Sciences

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Radiation is used in medicine to diagnose and treat diseases but it can also cause harm to the body by burning or mutation. This depends on whether the radiation is ionizing or nonionizing. Despite its vast applications in surgery, dermatology and cosmetics, little is taught and thus known about non-ionizing radiation. This review article discusses the fundamentals of non-ionizing electromagnetic radiations. The main aim is to extensively explain the different types of non-ionizing radiation. This will equip students and medical personnel with knowledge on different medical applications and expose them to a variety of specializations in medicine that utilize non-ionizing radiation. The article discusses the physics, hazard, means of protection and medical application of each type of radiation: ultraviolet radiation, light (both visible light and LASER), infrared radiation, microwaves and extremely low frequency radiation separately. It presents these terms in a simple manner that avoids rigors mathematics and physics, which makes them comprehensible for medical students. The development of new diagnostic and therapeutic approaches could also lead to increased hazards to the body unless they are treated with precaution. If not adequately monitored, a significant health risk may be posed to potentially exposed employees. Hence proper dosage should be used for non-ionizing radiation. This is only possible through understanding of the risks/benefits of these radiations by studying the physics and radiobiological effects of each individual radiation.

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Extremely low-frequency electromagnetic fields: A possible non-invasive therapeutic tool for spinal cord injury rehabilitation

Cited by 10 publications

References 147 publications

Effect of Rehabilitation with Extremely Low Frequency Electromagnetic Field on Molecular Mechanism of Apoptosis in Post-Stroke Patients

Effect of Rehabilitation with Extremely Low Frequency Electromagnetic Field on Molecular Mechanism of Apoptosis in Post-Stroke Patients

Electroacupuncture Facilitates the Integration of Neural Stem Cell-Derived Neural Network with Transected Rat Spinal Cord

Radiobiological effects and medical applications of non-ionizing radiation

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