Extremely rare synovial chondrosarcoma arising from the elbow joint: case report and review of the literature

Muramatsu, Keiichi; Miyoshi, Tetsuya; Moriya, Atsushi; Onaka, Hiroshi; Shigetomi, Mitsunori; Nakashima, Daisuke; Taguchi, Toshihiko

doi:10.1016/j.jse.2011.06.014

Cited by 19 publications

(19 citation statements)

References 19 publications

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“…Only 61 cases, including the 10 cases described in this study, have been reported in the English-language literature, as single case reports or small series (Figure 3; Table S2). [1][2][3][4][5][7][8][9][10]12,13,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] The age range at diagnosis in our series matches with previous findings. Likewise, our data confirm that synovial chondrosarcomas mostly arise from large joints, with the hip and the knee as the site of origin for~70% of all neoplasms [1][2][3][4][5][7][8][9][10]12,13,[17][18][19][20][21]…”

Section: Discussionsupporting

confidence: 89%

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Synovial chondrosarcoma: a single‐institution experience with molecular investigations and review of the literature

et al. 2020

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Aims To evaluate the available diagnostic histological criteria for synovial chondrosarcoma and to screen for the presence of IDH1/IDH2 mutations in a series of cases of this malignant cartilaginous neoplasm. Methods and results Ten cases of synovial chondrosarcoma diagnosed at our institute were reviewed. At presentation, all tumours occurred in adults (median age, 62 years). The most common location was the knee joint (five cases), and the size at diagnosis ranged from 30 mm to 170 mm. Eight patients had secondary synovial chondrosarcomas associated with pre‐existing/recurrent or concomitant synovial chondromatosis. Five patients had local recurrences and three had lung metastases. All patients with intralesional excisions developed local recurrences, whereas those who underwent wide resections did not. At last follow‐up (mean, 91 months), available for nine patients, seven patients were alive and disease‐free, one patient had died of disease, and one was alive with paravertebral metastases. Frequent histological features observed included loss of clustering of chondrocytes (nine cases), the presence of variable amounts of myxoid matrix (eight cases), peripheral hypercellularity (eight cases), tumour necrosis (six cases), and spindling of chondrocytes (four cases). Of the seven cases for which it was possible to evaluate bone permeation, six showed infiltration of bone marrow. All seven cases screened for mutations of exon 4 of IDH1 and IDH2 were found to be wild‐type. Conclusions Histological criteria in correlation with clinical and radiological features allow the recognition of synovial chondrosarcoma. IDH1/IDH2 mutations were not present in synovial chondrosarcoma. Adequate surgical margins are important for disease control.

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Section: Discussionsupporting

confidence: 89%

“…The mortality rate observed in our series (11%) is lower than that derived from all cases reported previously (23%). [1][2][3][4][5][7][8][9][10]12,13,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] Importantly, our median follow-up is longer than that reported in the literature (91 months versus 36 months).…”

Section: Discussionmentioning

confidence: 99%

Synovial chondrosarcoma: a single‐institution experience with molecular investigations and review of the literature

et al. 2020

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“…Synovial chondrosarcoma arising from chondromatosis is 1 of the rarest types of chondrosarcoma. 9 The current patient represents the only reported case in the literature with histologically and MRI-confirmed synovial elbow chondromatosis that underwent malignant change to chondrosarcoma. In addition, there was a distinctive metastasis of the tumor in subcutaneous areas.…”

Section: Discussionmentioning

confidence: 73%

“…9 There have been 5 reports in the literature of primary synovial chondrosarcoma without a chondromatosis stage. 4,[9][10][11] Muramatsu et al 9 presented a case of primary elbow chondrosarcoma in a 64-year-old man who underwent elbow arthroplasty after 2 years of uncontrollable right elbow pain. Preoperative MRI showed propagation of synovium inside the joint space and erosive changes on the radial head.…”

Section: Discussionmentioning

confidence: 99%

Odyssey of an Elbow Synovial Chondromatosis

Sachinis¹,

Sinopidis²,

Baliaka³

et al. 2015

Orthopedics

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Synovial chondromatosis of the elbow is an uncommon condition. However, a chondrosarcoma arising from the former is remarkably rare. The authors report a case of an elbow chondrosarcoma secondary to synovial chondromatosis in a 38-year-old woman. Before the development of chondrosarcoma, the patient underwent 3 operations and 3 sessions of radiosynovectomy because of continuous recurrence of synovial chondromatosis on the left elbow. After the last radiosynovectomy, magnetic resonance imaging and biopsy showed a grade II chondrosarcoma secondary to synovial chondromatosis. The patient underwent further surgery and custom-made arthroplasty because of aseptic loosening of the prosthesis. Four months after the last intervention, 3 subcutaneous nodes appeared on the patient's elbow and were histologically found to be a recurrence of chondrosarcoma (grade III). Amputation by disarticulation of the shoulder was performed in addition to biopsy of another subcutaneous node on the abdomen. The biopsy showed metastasis of chondrosarcoma. At final follow-up, the patient had lung metastasis 7 years after the initial diagnosis. A reason for the manifestation of primary synovial chondromatosis and its progression to chondrosarcoma has not been found. Synovial chondromatosis progressing to chondrosarcoma in the elbow was reported in only 1 case, with no clear initial diagnosis. The role of radiosynovectomy in the development of chondrosarcoma is unknown, and no reports have described the treatment of elbow synovial chondromatosis. Although synovial chondromatosis is benign, its metaplastic nature is a marker of possible malignancy, especially with signs of recurrence and aggression. The role of radiosynovectomy in malignant changes should be examined in future studies.

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“…The interphalangeal and metacarpophalangeal joints are the most frequently impacted hand joints. [3,[5][6][7] Pain, swelling, limited range of motion, and stiffness may be seen. [8] Diagnosis can be made based on plain radiograms, though magnetic resonance imaging (MRI) is the most valuable modality for early diagnosis and differential diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Synovyal Osteocondromatosıs In Metacarpophalengeal Joınt: A Case Report

Karaman¹

2017

South Clin Ist Euras

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Extremely rare synovial chondrosarcoma arising from the elbow joint: case report and review of the literature

Cited by 19 publications

References 19 publications

Synovial chondrosarcoma: a single‐institution experience with molecular investigations and review of the literature

Synovial chondrosarcoma: a single‐institution experience with molecular investigations and review of the literature

Odyssey of an Elbow Synovial Chondromatosis

Synovyal Osteocondromatosıs In Metacarpophalengeal Joınt: A Case Report

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