Extremophilic Fungi as a Source of Bioactive Molecules

Das, Annada; Satyaprakash, Kaushik; Das, Anubrata

doi:10.1007/978-981-16-4907-3_21

Cited by 3 publications

(3 citation statements)

References 141 publications

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“…Chromatographic separation and molecular identification of the obtained fragments of Malbranchea sulfurea metabolites revealed six light-sensitive polyketides called malbran pyrroles A–F with cytotoxic activities against PANC-1, HepG 2 , and MCF-7 cancer cell lines, with their IC 50 values in the range from 3 to 11 μM 42 [ 42 , 51 ]. More metabolites of this group of fungi and their biological activities are listed in Table 1 , with their half inhibitory concentrations (IC50), specifically on human cancer cell lines, unless otherwise, stated.…”

Section: Fungi Of Extreme Temperature Conditionsmentioning

confidence: 99%

“…In addition, they can be also classified based on the environments in which they can thrive, for instance, the organisms that grow at high temperatures are termed thermophilic and hyperthermophilic; the psychrophilics that can grow at low temperatures; or those who are adapted to acidic or basic pH environments and are referred to as acidophilic or alkaliphilic. The species that grow in high-pressure conditions, such as in the deep sea or underground, are called piezophilic or barophilic, and finally, there are organisms that require NaCl to grow or survive in environments with high salt concentrations and low water activity (aw) that are generally called halophilic [ 50 , 51 ].…”

Section: Introductionmentioning

confidence: 99%

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The Cytotoxic Properties of Extreme Fungi’s Bioactive Components—An Updated Metabolic and Omics Overview

Kiss

Akbari

Marchev

et al. 2023

Life

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Fungi are the most diverse living organisms on planet Earth, where their ubiquitous presence in various ecosystems offers vast potential for the research and discovery of new, naturally occurring medicinal products. Concerning human health, cancer remains one of the leading causes of mortality. While extensive research is being conducted on treatments and their efficacy in various stages of cancer, finding cytotoxic drugs that target tumor cells with no/less toxicity toward normal tissue is a significant challenge. In addition, traditional cancer treatments continue to suffer from chemical resistance. Fortunately, the cytotoxic properties of several natural products derived from various microorganisms, including fungi, are now well-established. The current review aims to extract and consolidate the findings of various scientific studies that identified fungi-derived bioactive metabolites with antitumor (anticancer) properties. The antitumor secondary metabolites identified from extremophilic and extremotolerant fungi are grouped according to their biological activity and type. It became evident that the significance of these compounds, with their medicinal properties and their potential application in cancer treatment, is tremendous. Furthermore, the utilization of omics tools, analysis, and genome mining technology to identify the novel metabolites for targeted treatments is discussed. Through this review, we tried to accentuate the invaluable importance of fungi grown in extreme environments and the necessity of innovative research in discovering naturally occurring bioactive compounds for the development of novel cancer treatments.

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Section: Fungi Of Extreme Temperature Conditionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Cytotoxic Properties of Extreme Fungi’s Bioactive Components—An Updated Metabolic and Omics Overview

Kiss

Akbari

Marchev

et al. 2023

Life

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“…Using these metabolites with the help of nanotechnology will be used as a powerful tool in pharmaceutical sciences. [11][12][13] They can produce biological metabolites that have certain actions such as antibacterial, antifungal, antioxidant, and anticancer. The overuse of basically antibiotic drugs has resulted in the development of drug resistance (DR), which reduces or eliminates their efficacy.…”

Section: Introductionmentioning

confidence: 99%

Salt Tolerant Microbes (Active Metabolites) Mediated Nanoparticle: Drug Delivery and Future Prospects

Priya,

Joshi,

Rautela

et al. 2024

J. Pure Appl. Microbiol.

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Salt Tolerant Microbes are a group of microorganisms that grow, develop, and survive in extremely high salt concentrations. Based on their tolerance level they generally grow up optimally at pH values beyond 9.0, but the growth is inhibited at the pH value that is most closely associated with neutral 6.5. They have minimal dietary needs and a good salt quantity that is high enough to osmotic pressure. They can produce biological metabolites that have certain actions such as antibacterial, antifungal, antioxidant, and anticancer. We discussed in this article various pharmaceutical formulations of salt-tolerant microbes, every formulation shows the specific pharmacological actions like anti-cancer activity, anti-oxidant activity, and anti-microbial activity, and also discusses methods for the biosynthesis of salt-tolerant microbes’ nanoparticles.

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Role of Bioactive Compounds Synthesized by Extremophilic Microbes and Their Bioactivity

Narayanan,

Devi,

Kandhasamy

et al. 2024

Reference Series in Phytochemistry

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Extremophilic Fungi as a Source of Bioactive Molecules

Cited by 3 publications

References 141 publications

The Cytotoxic Properties of Extreme Fungi’s Bioactive Components—An Updated Metabolic and Omics Overview

The Cytotoxic Properties of Extreme Fungi’s Bioactive Components—An Updated Metabolic and Omics Overview

Salt Tolerant Microbes (Active Metabolites) Mediated Nanoparticle: Drug Delivery and Future Prospects

Role of Bioactive Compounds Synthesized by Extremophilic Microbes and Their Bioactivity

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