Extrinsic aging

Tsatsou, Fragkiski; Trakatelli, M.; Patsatsi, Aikaterini; Kalokasidis, Konstantinos; Sotiriadis, Dimitrios

doi:10.4161/derm.22519

Cited by 57 publications

(19 citation statements)

References 62 publications

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“…UVB exposure causes photoaging, wrinkling, and pigmentation [ 22 ]. The UVB-irradiated group treated with AFWE showed no alteration in cellular morphology ( Figure S2C ), and no cell death was seen in the control or positive control groups ( Figure 6 A).…”

Section: Resultsmentioning

confidence: 99%

“…Thus, it is obvious that the activation of PKC, P38, and deactivation of ERK are all known to regulate the IVL expression. UVB exposure causes photoaging, wrinkling, and pigmentation [22]. The UVB-irradiated group treated with AFWE showed no alteration in cellular morphology…”

Section: Afwe and Io Both Confirm The Regulatory Role Of Pkc And Mapk Signaling In Ivl Expressionmentioning

confidence: 91%

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Effects of Aloe vera Flower Extract and Its Active Constituent Isoorientin on Skin Moisturization via Regulating Involucrin Expression: In Vitro and Molecular Docking Studies

Sultana

Park

Shin³

et al. 2021

Molecules

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Skin moisturization is very crucial for maintaining the flexibility, viscoelasticity, and differentiation of the epidermis and its deprivation causes several diseases from dry skin to dermatitis. Aloe vera, a miracle plant having diverse medicinal properties including skin moisturization effects. This study investigated for the first time the molecular mechanism targeting skin moisturization effects of the Aloe vera flower and its major active constituent. By treating human epidermal keratinocytes (HaCaT cells) with Aloe vera flower water extract (AFWE), we found that AFWE upregulated epidermal involucrin by activating the expression of protein kinase C, p38, and ERK 1/2. Additionally, it modulated filaggrin, increased aquaporin expression, and hyaluronan synthesis via a balanced regulation of HAS1 and HYAL1 protein. Similarly, it was able to protect UVB-induced photodamage. Western blot analysis, ELISA, and qRT- PCR were performed to evaluate various epidermal differentiation markers and moisturization-related factors on human epidermal keratinocytes (HaCaT cells). TLC and HPLC were used to detect and analyze the chemical constituents. Among them, we found that an active component of Aloe vera flower, isoorientin (IO) has a high binding affinity to all of its targeted proteins such as involucrin, PKC, P38, etc. through molecular docking assay. This study indicated that the Aloe vera flower and its active constituent, IO can be used as a prominent ingredient to enhance skin barrier function and improve its related pathologies.

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Section: Resultsmentioning

confidence: 99%

Section: Afwe and Io Both Confirm The Regulatory Role Of Pkc And Mapk Signaling In Ivl Expressionmentioning

confidence: 91%

Effects of Aloe vera Flower Extract and Its Active Constituent Isoorientin on Skin Moisturization via Regulating Involucrin Expression: In Vitro and Molecular Docking Studies

Sultana

Park

Shin³

et al. 2021

Molecules

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“…It was shown that damage to ESC DNA by low-dose ionizing radiation significantly induced DSBs-mediated chromatin modifications and that DSBs may also be passed on to their differentiated cell lineages [ 44 ]. Persistent exposure to UVR also increased DNA damaged lesions and mutations and led to premature aging or carcinogenesis of the skin [ 45 ].…”

Section: Uv-induced Depletion Of Skin Stem Cells: a Multipronged Amentioning

confidence: 99%

Ultraviolet Radiation‐Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging

Panich

Sittithumcharee

Rathviboon

et al. 2016

Stem Cells International

264

199

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Skin is the largest human organ. Skin continually reconstructs itself to ensure its viability, integrity, and ability to provide protection for the body. Some areas of skin are continuously exposed to a variety of environmental stressors that can inflict direct and indirect damage to skin cell DNA. Skin homeostasis is maintained by mesenchymal stem cells in inner layer dermis and epidermal stem cells (ESCs) in the outer layer epidermis. Reduction of skin stem cell number and function has been linked to impaired skin homeostasis (e.g., skin premature aging and skin cancers). Skin stem cells, with self-renewal capability and multipotency, are frequently affected by environment. Ultraviolet radiation (UVR), a major cause of stem cell DNA damage, can contribute to depletion of stem cells (ESCs and mesenchymal stem cells) and damage of stem cell niche, eventually leading to photoinduced skin aging. In this review, we discuss the role of UV-induced DNA damage and oxidative stress in the skin stem cell aging in order to gain insights into the pathogenesis and develop a way to reduce photoaging of skin cells.

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“…Intrinsic aging is a normal physiological process characterized by decreased cell proliferation in basal layers and accumulation of senescent cells in epidermis and dermis resulting in skin dryness, thinning, fine wrinkles, itching [ 1 ], and susceptibility to many skin disorders, such as infections, autoimmune disorders, and malignancy [ 2 ]. External factors, including pollutants, smoking, diet, temperature, and especially ultraviolet and infrared radiation have larger influence on aggravation of inflammation and aging phenotypes such as wrinkles, irregular pigmentation, skin dryness, and decreased dermal and epidermal thickness [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging

Ansary

Hossain

Kamiya

et al. 2021

IJMS

171

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Skin is the largest and most complex organ in the human body comprised of multiple layers with different types of cells. Different kinds of environmental stressors, for example, ultraviolet radiation (UVR), temperature, air pollutants, smoking, and diet, accelerate skin aging by stimulating inflammatory molecules. Skin aging caused by UVR is characterized by loss of elasticity, fine lines, wrinkles, reduced epidermal and dermal components, increased epidermal permeability, delayed wound healing, and approximately 90% of skin aging. These external factors can cause aging through reactive oxygen species (ROS)-mediated inflammation, as well as aged skin is a source of circulatory inflammatory molecules which accelerate skin aging and cause aging-related diseases. This review article focuses on the inflammatory pathways associated with UVR-mediated skin aging.

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Extrinsic aging

Cited by 57 publications

References 62 publications

Effects of Aloe vera Flower Extract and Its Active Constituent Isoorientin on Skin Moisturization via Regulating Involucrin Expression: In Vitro and Molecular Docking Studies

Effects of Aloe vera Flower Extract and Its Active Constituent Isoorientin on Skin Moisturization via Regulating Involucrin Expression: In Vitro and Molecular Docking Studies

Ultraviolet Radiation‐Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging

Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging

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