2022
DOI: 10.1101/2022.05.03.490384
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Extrinsic regulation of interneuron specification and migration

Abstract: The imbalance between excitatory and inhibitory neurons in the human brain might lead to neurodevelopmental and neuropsychiatric disorders including cortical malformations, epilepsy, and autism spectrum disorders. We propose that the extracellular environment regulates interneuron differentiation and migration during development, ultimately affecting the excitatory/inhibitory balance.Using ventral cerebral organoids and dorso-ventral cerebral assembloids with mutations in the extracellular matrix gene LGALS3BP… Show more

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Cited by 2 publications
(1 citation statement)
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References 82 publications
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“…[95] A recent study demonstrates the impact of non-cell autonomous signaling via EVs on neuronal specification and migration during corticogenesis. [96] This field is in its infancy and will likely yield many more insights; thus, at this point, a possible involvement of HNRNPU cannot be ruled out.…”
Section: Sorting Of Ncrnas To Evsmentioning
confidence: 99%
“…[95] A recent study demonstrates the impact of non-cell autonomous signaling via EVs on neuronal specification and migration during corticogenesis. [96] This field is in its infancy and will likely yield many more insights; thus, at this point, a possible involvement of HNRNPU cannot be ruled out.…”
Section: Sorting Of Ncrnas To Evsmentioning
confidence: 99%