Extruded, Partially Disintegrated, Poly-HEMA Orbital Implant (AlphaSphere)

Yadav, Prashant; Castro, Dawn K. De; Mendoza, Pia R.; Fay, Aaron

doi:10.1097/iop.0b013e31829f3b5c

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…Although the behavior of different cells such as cartilage, bone, melanoma on Poly‐HEMA have been under precise investigations, the effect of polymer in preserving RPE cells' nature or stem cells’ features have not yet been studied [Lombello et al, ; Flynn et al, ; Yadav et al, ].…”

Section: Discussionmentioning

confidence: 99%

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Induced Retro‐Differentiation of Human Retinal Pigment Epithelial Cells on PolyHEMA

Nazemroaya

Soheili

Samiei

et al. 2017

J of Cellular Biochemistry

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Retinal pigment epithelium (RPE) cells represent a great potential to rescue degenerated cells of the damaged retina. Activation of the virtually plastic properties of RPE cells may aid in recovery of retinal degenerative disorders without the need for entire RPE sheet transplantation. Poly (2‐hydroxyethyl methacrylate)(PolyHEMA) is one of the most important hydrogels in the biomaterials world. This hydrophobic polymer does not normally support attachment of mammalian cells. In the current study we investigated the effect of PolyHEMA as a cell culture substrate on the growth, differentiation, and plasticity of hRPE cells. hRPE cells were isolated from neonatal human globes and cultured on PolyHEMA and polystyrene substrates (as controls) in 24‐well culture plates. DMEM/F12 was supplemented with 10% fetal bovine serum (FBS) and/or 30% human amniotic fluid (HAF) for cultured cells on polystyrene and PolyHEMA coated vessels. Morphology, rate of cell proliferation and cell death, MTT assay, immunocytochemistry and Real‐Time RT‐PCR were performed to investigate the effects of PolyHEMA on the growth and differentiation of cultured hRPE cells. Proliferation rate of the cells that had been cultured on PolyHEMA was reduced; PolyHEMA did not induce cell death in the hRPE cultures. hRPE cells cultured on PolyHEMA formed many giant spheroid colonies. The giant colonies were re‐cultured and the presence of retinal progenitor markers and markers of hRPE cells were detected in cell cultures on PolyHEMA. PolyHEMA seems to be promising for both maintenance and de‐differentiation of hRPE cells and expansion of the retinal progenitor cells from the cultures that are originated from hRPE cells. J. Cell. Biochem. 118: 3080–3089, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

“…This flexible, soft, and water absorbing plastic is the basic component of contact lenses [Chirila, 1993;Seidel and Malmonge, 2000;Olabisi, 2015]. It is also used in implantation of soft tissues, synthetic transplant for gristle and bone, regeneration of neurotic tissue, transmission of drug and etc [Lombello et al, 2000;Flynn et al, 2003;Yadav et al, 2014].…”

mentioning

confidence: 99%

Induced Retro‐Differentiation of Human Retinal Pigment Epithelial Cells on PolyHEMA

Nazemroaya

Soheili

Samiei

et al. 2017

J of Cellular Biochemistry

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“…However, Yadav and his team presented a case of a 54-year-old diabetic patient who underwent a secondary Alphasphere implant after enucleation due to endophthalmitis. Six weeks later, the implant's deterioration necessi-tated removal, with further investigation revealing it prompted a severe and irreversible host tissue reaction without signs of infection [164]. In a case highlighted by Neimkin et al, a 57-year-old female who underwent enucleation for choroidal melanoma and received an Alphasphere implant faced implant failure after 2 years, despite an initially uneventful recovery.…”

Section: Poly(methylmethacrylate) (Pmma)mentioning

confidence: 99%

The Use of Functional Biomaterials in Aesthetic and Functional Restoration in Orbital Surgery

Wu,

Fujioka,

Daigle

et al. 2024

JFB

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The integration of functional biomaterials in oculoplastic and orbital surgery is a pivotal area where material science and clinical practice converge. This review, encompassing primary research from 2015 to 2023, delves into the use of biomaterials in two key areas: the reconstruction of orbital floor fractures and the development of implants and prostheses for anophthalmic sockets post-eye removal. The discussion begins with an analysis of orbital floor injuries, including their pathophysiology and treatment modalities. It is noted that titanium mesh remains the gold standard for orbital floor repair due to its effectiveness. The review then examines the array of materials used for orbital implants and prostheses, highlighting the dependence on surgeon preference and experience, as there are currently no definitive guidelines. While recent innovations in biomaterials show promise, the review underscores the need for more clinical data before these new materials can be widely adopted in clinical settings. The review advocates for an interdisciplinary approach in orbital surgery, emphasizing patient-centered care and the potential of biomaterials to significantly enhance patient outcomes.

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“…For instance, Yadav et al presented a case in which a patient with diabetes experienced a significant and irreversible reaction to an Alphasphere implant. This reaction occurred without any signs of infection, suggesting that the implant itself might have triggered an adverse response in the host tissue [ 53 ]. Furthermore, Neimkin et al documented a case in which a patient underwent enucleation for choroidal melanoma and received an Alphasphere implant.…”

Section: Oculoplastic and Orbital Surgery Devicesmentioning

confidence: 99%

Biopolymeric Innovations in Ophthalmic Surgery: Enhancing Devices and Drug Delivery Systems

Wu,

Khan,

Liao

et al. 2024

Polymers

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The interface between material science and ophthalmic medicine is witnessing significant advances with the introduction of biopolymers in medical device fabrication. This review discusses the impact of biopolymers on the development of ophthalmic devices, such as intraocular lenses, stents, and various prosthetics. Biopolymers are emerging as superior alternatives due to their biocompatibility, mechanical robustness, and biodegradability, presenting an advance over traditional materials with respect to patient comfort and environmental considerations. We explore the spectrum of biopolymers used in ophthalmic devices and evaluate their physical properties, compatibility with biological tissues, and clinical performances. Specific applications in oculoplastic and orbital surgeries, hydrogel applications in ocular therapeutics, and polymeric drug delivery systems for a range of ophthalmic conditions were reviewed. We also anticipate future directions and identify challenges in the field, advocating for a collaborative approach between material science and ophthalmic practice to foster innovative, patient-focused treatments. This synthesis aims to reinforce the potential of biopolymers to improve ophthalmic device technology and enhance clinical outcomes.

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Extruded, Partially Disintegrated, Poly-HEMA Orbital Implant (AlphaSphere)

Cited by 5 publications

References 10 publications

Induced Retro‐Differentiation of Human Retinal Pigment Epithelial Cells on PolyHEMA

Induced Retro‐Differentiation of Human Retinal Pigment Epithelial Cells on PolyHEMA

The Use of Functional Biomaterials in Aesthetic and Functional Restoration in Orbital Surgery

Biopolymeric Innovations in Ophthalmic Surgery: Enhancing Devices and Drug Delivery Systems

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