Extruded sorghum consumption associated with a caloric restricted diet reduces body fat in overweight men: A randomized controlled trial

Anunciação, Pamella Cristine; Cardoso, Leandro de Morais; Alfenas, Rita de Cássia Gonçalves; Queiróz, Valéria Aparecida Vieira; Carvalho, Carlos Wanderlei Piler de; Martino, Hércia Stampini Duarte; Pinheiro-Sant’Ana, Helena Maria

doi:10.1016/j.foodres.2018.10.048

Cited by 33 publications

(17 citation statements)

References 40 publications

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“…Interestingly, a sorghum drink containing high levels of proanthocyanidin (condensed tannins) performed better than the two other sorghum drinks that did not contain proanthocyanidins at reducing blood glucose [ 12 ]. Human clinical trials also indicated that consumption of flaked biscuits made from whole grain sorghum led to higher satiety compared to participants receiving the wheat treatment [ 13 ] and consumption of extruded sorghum combined with a calorie-restricted diet significantly promoted weight loss and decreased waist circumference and body fat percentage and performed better than wheat [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Adipogenic Activity of High-Phenolic Sorghum Brans in Pre-Adipocytes

et al. 2022

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Obesity is one of the leading public health problems that can result in life-threatening metabolic and chronic diseases such as cardiovascular diseases, diabetes, and cancer. Sorghum (Sorghum bicolor (L.) Moench) is the fifth most important cereal crop in the world and certain genotypes of sorghum have high polyphenol content. PI570481, SC84, and commercially available sumac sorghum are high-polyphenol genotypes that have demonstrated strong anti-cancer activities in previous studies. The objective of this study was to explore a potential anti-obesity use of extracts from sorghum bran in the differentiation of 3T3-L1 preadipocytes and to investigate cellular and molecular responses in differentiated adipocytes to elucidate related mechanisms. None of the four different sorghum bran extracts (PI570481, SC84, Sumac, and white sorghum as a low-polyphenol control) caused cytotoxicity in undifferentiated and differentiated 3T3-L1 cells at doses used in this study. Sorghum bran extracts (PI570481, SC84, and Sumac) reduced intracellular lipid accumulation and expression of adipogenic and lipogenic proteins in a dose-dependent manner in differentiated 3T3-L1 cells. The same polyphenol containing sorghum bran extracts also repressed production of reactive oxygen species (ROS) and MAPK signaling pathways and repressed insulin signaling and glucose uptake in differentiated 3T3-L1 cells. These data propose a potential use of high-phenolic sorghum bran for the prevention of obesity.

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Section: Introductionmentioning

confidence: 99%

Anti-Adipogenic Activity of High-Phenolic Sorghum Brans in Pre-Adipocytes

et al. 2022

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“…Finger millet, foxtail millet, barnyard millet, and/or a mixture of millets (finger millet and little millet) were used in the 19 studies (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36) that were included in one or more outcomes of meta-analysis. It was observed that consumption of milletbased food for a duration varying from 21 days to 4 months had a significant reducing effect on TC, triacylglycerol, VLDL-C, and/or LDL-C levels.…”

Section: Resultsmentioning

confidence: 99%

Can Millet Consumption Help Manage Hyperlipidemia and Obesity?: A Systematic Review and Meta-Analysis

et al. 2021

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Many health benefits of millets (defined broadly to also include sorghum) have been advocated, including their roles in managing and preventing diabetes; however, the effects of millets on hyperlipidemia (high lipid levels) have been underrecognized. A systematic review and meta-analysis were conducted to collate available evidence of the impacts of millets consumption on lipid profile, namely total cholesterol (TC), triacylglycerol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and very-low–density lipoprotein cholesterol (VLDL-C). The results from 19 studies showed that the consumption of millets for periods as short as 21 days to 4 months reduced levels of TC, triacylglycerol, LDL-C, and VLDL-C (p<0.01) by 8.0, 9.5, 10 and 9.0%, respectively. Four studies demonstrated that millets consumption brought TC and triacylglycerol levels to the normal levels (<200 and <150 mg/dl, respectively). Furthermore, upon consumption of millet-based meals, there was a 6.0% increase in the HDL-C 4.0 and 5.0% reduction in systolic and diastolic blood pressure, and 7.0% reduction in body mass index (BMI). This evidence, leads us to conclude that consumption of millets reduces hyperlipidemia and hence hypertension, and raises the levels of HDL-C (good cholesterol), which can be beneficial for managing the associated risk of developing hypertension and atherosclerotic cardiovascular diseases in future.Systematic Review Registration: The protocol of this systematic review has been registered in the online registration platform called “research registry” with the unique identification number “reviewregistry1123.”

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“…In the catechines class, green tea and coffee were also reported for the significant reduction of body weight and maintenance of the body weight in average condition. Sorghum bicolor L. has been demonstrated to be a worthy substitute to control obesity in weighty men because it reduces body fat fraction and amplifies daily carbohydrate and dietary fiber consumption when compared to wheat consumption [ 169 ]. Nowadays, people are having a great interest in herbal plant compositions or phytochemicals due to safer and efficacious effects, and the clinical studies must not be limited to in vitro or in vivo levels for their development.…”

Section: Clinical Studies: Translational Potential Of Natural Product...mentioning

confidence: 99%

Biogenic Phytochemicals Modulating Obesity: From Molecular Mechanism to Preventive and Therapeutic Approaches

Kumar

Singh

Lakhawat

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The incidence of obesity and over bodyweight is emerging as a major health concern. Obesity is a complex metabolic disease with multiple pathophysiological clinical conditions as comorbidities are associated with obesity such as diabetes, hypertension, cardiovascular disorders, sleep apnea, osteoarthritis, some cancers, and inflammation-based clinical conditions. In obese individuals, adipocyte cells increased the expression of leptin, angiotensin, adipocytokines, plasminogen activators, and C-reactive protein. Currently, options for treatment and lifestyle behaviors interventions are limited, and keeping a healthy lifestyle is challenging. Various types of phytochemicals have been investigated for antiobesity potential. Here, we discuss pathophysiology and signaling pathways in obesity, epigenetic regulations, regulatory mechanism, functional ingredients in natural antiobesity products, and therapeutic application of phytochemicals in obesity.

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Extruded sorghum consumption associated with a caloric restricted diet reduces body fat in overweight men: A randomized controlled trial

Cited by 33 publications

References 40 publications

Anti-Adipogenic Activity of High-Phenolic Sorghum Brans in Pre-Adipocytes

Anti-Adipogenic Activity of High-Phenolic Sorghum Brans in Pre-Adipocytes

Can Millet Consumption Help Manage Hyperlipidemia and Obesity?: A Systematic Review and Meta-Analysis

Biogenic Phytochemicals Modulating Obesity: From Molecular Mechanism to Preventive and Therapeutic Approaches

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