In order to enhance design reliability of a co-rotating twin screw pulping extruder (TSPE), optimum design on screw parameters of the TSPE was studied based on the extrusion model. The maximum shear flux or the minimum power consumption, or the two synchronous optimizations were taken as objective functions, and constraint conditions, such as thread lead, depth of thread, screw rotational speed, number of reverse thread lead, actual top width of the flight, torsional strength and stiffness of the screw mandrel, and so on were confirmed base on actual requirements of the TSPE manufacture and application. The optimizing results show that two-objective optimum design results split the difference of the two single-objective optimum design, and it is the most economical in reducing manufacture cost of the equipment and pulping expenses.