Exuberant bullous vasculitis associated with SARS-CoV-2 infection

Gouveia, Pedro Alves da Cruz; Cipriano, Ingrid Cardoso; Melo, Marina Acevedo Zarzar de; Silva, Helena Texeira Araujo da; Amorim, Matheus Augusto de Oliveira; Leitão, Clezio Cordeiro de Sá; Guedes, Maria Magalhães Vasconcelos; Takano, Daniela Mayumi; Filgueira, Norma Arteiro; Ferraz, Cláudia Elise

doi:10.1016/j.idcr.2021.e01047

Cited by 11 publications

(9 citation statements)

References 10 publications

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“…The reported occurrence of vascular lesions supports the hypothesis that endothelial dysfunction plays a key role in organ injury 2 . Many hypotheses have been advanced to explain the onset of endothelial damage in COVID‐19 patients: It has been considered as an immunological reaction to viral antigens deposition; also, immune activation, especially high level of IL‐6, and the stimulation of the coagulation system due to viral load have been proposed as possible triggers 3 …”

Section: Figurementioning

confidence: 58%

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Bullous dermatosis on the hands following SARS‐CoV‐2 infection

et al. 2021

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Section: Figurementioning

confidence: 58%

“…In case of prominent vascular damage, conspicuous bullous lesions may appear; however, only few cases of extended bullous vasculitis following the novel coronavirus infections have been reported so far 3,4 . Importantly, the published evidence described bullous lesions which were primarily localized on the lower extremities 3,4 …”

Section: Figurementioning

confidence: 99%

Bullous dermatosis on the hands following SARS‐CoV‐2 infection

et al. 2021

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“…52,98 The cardinal symptom is palpable purpura mainly concerning dependent areas of the body, notably the lower legs, but may also affect thighs, arms, and abdomen. [99][100][101] In cases with high levels of inflammation, bullae and necrosis may develop in the purpuric skin lesions. 99 Skin symptoms may be accompanied by fever, fatigue, or arthralgia.…”

Section: Small Vessel Vasculitismentioning

confidence: 99%

“…[99][100][101] In cases with high levels of inflammation, bullae and necrosis may develop in the purpuric skin lesions. 99 Skin symptoms may be accompanied by fever, fatigue, or arthralgia. 52 Small vessel vasculitis has been described as a cutaneous manifestation in COVID-19.…”

Section: Small Vessel Vasculitismentioning

confidence: 99%

Microvascular Skin Manifestations Caused by COVID-19

Gawaz

Guenova

2021

Hamostaseologie

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Hypercoagulability and vascular injury, which characterize morbidity in COVID-19 disease, are frequently observed in the skin. Several pathomechanisms, such as inflammation caused by angiotensin-converting enzyme 2–mediated uptake into endothelial cells or SARS-CoV-2-initiated host immune responses, contribute to microthrombus formation and the appearance of vascular skin lesions. Besides pathophysiologic mechanisms observed in the skin, this review describes the clinical appearance of cutaneous vascular lesions and their association with COVID-19 disease, including acro-ischemia, reticular lesions, and cutaneous small vessel vasculitis. Clinicians need to be aware that skin manifestations may be the only symptom in SARS-CoV-2 infection, and that inflammatory and thrombotic SARS-CoV-2-driven processes observed in multiple organs and tissues appear identically in the skin as well.

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“…[ 44 45 ] Atypical presentation with hemorrhagic bullous morphology in leukocytoclastic vasculitis has been described in COVID-19 patients. [ 46 47 ] Drug-induced vasculitis has to be kept in mind as a differential diagnosis of vasculitic lesions in the COVID-19 patients, as they are on multiple drugs during the presentation. The response of these lesions to oral corticosteroids is excellent.…”

Section: Cutaneous Manifestations Of Covid-19 Diseasementioning

confidence: 99%

Dermatological Manifestations Associated with COVID-19 Infection

Panda

Dash

Behera

et al. 2021

Indian Journal of Dermatology

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The severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) causing the 2019 coronavirus disease (COVID-19) has infected millions in recent years and is a major public health concern. Various cutaneous manifestations of the COVID-19 disease have been identified. Skin is a mirror to internal disease and can be the presenting sign of COVID-19 disease. Several cutaneous manifestations can indicate severe COVID-19 disease. In the present scenario, physicians should know the various cutaneous manifestations of COVID-19 disease for early diagnosis and proper management of the disease.

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Exuberant bullous vasculitis associated with SARS-CoV-2 infection

Cited by 11 publications

References 10 publications

Bullous dermatosis on the hands following SARS‐CoV‐2 infection

Bullous dermatosis on the hands following SARS‐CoV‐2 infection

Microvascular Skin Manifestations Caused by COVID-19

Dermatological Manifestations Associated with COVID-19 Infection

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