Eye and systemic manifestations of Mobius syndrome

Background A growing link between prenatal exposure to misoprostol (PEM) and Moebius syndrome (MS) or sequence has been reported. Our objectives were to describe the craniofacial clinical manifestations associated with MS and to determine the frequency of PEM, comparing cases of exposure and nonexposure. Methods A descriptive, cross‐sectional study of 140 patients with MS. Clinical evaluations, as well as 140 interviews with mothers residing in 39 cities or districts of Colombia, were carried out between April 2008 and May 2018. Additionally, previous clinical history of each case was reviewed. Results The average age of the patients with MS was 8.4 years (29 days to 48 years). All of them presented facial nerve involvement and abducens, 112 (80.8%) with bilateral facial paralysis. 98.5% presented craniofacial disorders, and there were no significant differences between those exposed and not exposed to misoprostol. Forty‐seven percentage of patients (64 cases) presented PEM, in 98.4% of which abortion had been intended. Conclusion PEM could have an influence in the appearance of new cases of MS by increasing the frequency of bleeding during gestation, without increasing the number of associated craniofacial malformations. We present the biggest series on MS and craniofacial findings in the literature, along with a meaningful reference for its understanding. Level of Evidence 3b.

show abstract

Moebius syndrome: Craniofacial clinical manifestations and their association with prenatal exposure to misoprostol

Ruge‐Peña

Valencia

Cabrera

et al. 2020

Laryngoscope Investig Oto

View full text Add to dashboard Cite

show abstract

Unmasking a Mask-like Face

Adhisivam

2014

The Journal of Pediatrics

View full text Add to dashboard Cite

Síndrome de Moebius: reporte de un caso

Mederos-Mollineda

Fernández-Vélez

Borrego

et al. 2017

Neurología Argentina

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Eye and systemic manifestations of Mobius syndrome

Cited by 4 publications

References 34 publications

Moebius syndrome: Craniofacial clinical manifestations and their association with prenatal exposure to misoprostol

Moebius syndrome: Craniofacial clinical manifestations and their association with prenatal exposure to misoprostol

Unmasking a Mask-like Face

Síndrome de Moebius: reporte de un caso

Contact Info

Product

Resources

About