Eye Changes in Autoimmune NZB and NZB x NZW Mice

Kessler, Harry S.; Cubberly, Margaret; Manski, W.

doi:10.1001/archopht.1971.00990050213016

Cited by 34 publications

(11 citation statements)

References 6 publications

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“…In general, the earliest mouse models of SS were inbred strains that exhibited SS-like disease manifestations spontaneously, e.g., NZB/NZW and Non-obese diabetic (NOD), two lines originally used to study lupus and diabetes, respectively [23,24]. While no one inbred mouse line should be expected to fully mimic all relevant phenotypes of SS disease, these spontaneous models, taken as a group, exhibit much of the heterogeneity seen in the complex genetics, diverse disease phenotypes, underlying pathology, and clinical manifestations present in patients with SS.…”

Section: Ss-like Disease In Mouse Modelsmentioning

confidence: 99%

What can Sjögren's syndrome-like disease in mice contribute to human Sjögren's syndrome?

Peck

Nguyen

2017

Clinical Immunology

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For decades, Sjögren’s syndrome (SS) and Sjögren’s syndrome-like (SS-like) disease in patients and mouse models, respectively, have been intensely investigated in attempts to identify the underlying etiologies, the path-ophysiological changes defining disease phenotypes, the nature of the autoimmune responses, and the propensity for developing B cell lymphomas. An emerging question is whether the generation of a multitude of mouse models and the data obtained from their studies is actually important to the understanding of the human disease and potential interventional therapies. In this brief report, we comment on how and why mouse models can stimulate interest in specific lines of research that apparently parallel aspects of human SS. Focusing on two mouse models, NOD and B6·Il14α, we present the possible relevance of mouse models to human SS, highlighting a few selected disease-associated biological processes that have baffled both SS and SS-like investigations for decades.

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Section: Ss-like Disease In Mouse Modelsmentioning

confidence: 99%

What can Sjögren's syndrome-like disease in mice contribute to human Sjögren's syndrome?

Peck

Nguyen

2017

Clinical Immunology

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“…In NZW mice, exocrine gland inflammation is more pronounced in females compared with males, whereas this phenomenon is generally less apparent in NZB mice [20,21]. …”

Section: Murine Models Of Spontaneous Diseasementioning

confidence: 99%

Sjögren's syndrome: studying the disease in mice

et al. 2011

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Sjögren's syndrome (SS), a systemic autoimmune disease, is characterized by inflammation of exocrine tissues accompanied by a significant loss of their secretory function. Clinical symptoms develop late and there are no diagnostic tests enabling early diagnosis of SS. Thus, particularly to study these covert stages, researchers turn to studying animal models where mice provide great freedom for genetic manipulation and testing the effect of experimental intervention. The present review summarizes current literature pertaining to both spontaneous and extrinsic-factor induced SS-like diseases in mouse models, discussing advantages and disadvantages related to the use of murine models in SS research.

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“…The disease starts by the age of 6 months, it is more aggressive in females. It can be worsened with aging and by inflammatory challenge with Freund's incomplete adjuvant [47-50]. …”

Section: Historymentioning

confidence: 99%

Sjögren syndrome

Paiva

Rocha

2015

Current Opinion in Ophthalmology

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Purpose of review Sjögren Syndrome (SS) affects exocrine glands leading to dry mouth and dry eye. Dry eye manifestations can precede the diagnosis of SS in by many years. Innumerous spontaneous and inducible SS models have been used to study pathogenesis of SS. This review focuses on recent human data, ocular and extra-glandular manifestations of animal models, what is known, what is still unknown and how we need to look, and their correlation correspondence to the human disease. Recent findings Hallmarks of dry eye in SS include increased corneal staining, goblet cell loss and low tear volume. Confocal microscopy and impression cytology is being able to clarify new markers of the ocular disease. Extra-glandular manifestations should alert for more severe complications in the eye. Some models have strong gender and exocrine gland predilection while aging generally worsens disease phenotype. While most models do not display a significant increase in corneal staining or tear secretion impairment, conjunctival infiltration and decrease in goblet cells are frequent seen. Summary We have seen great advances in the role of inflammation in ocular, oral and extra-glandular manifestations of SS. Several of the understanding of mechanisms and mediators of SS were elucidated in animal model studies.

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Eye Changes in Autoimmune NZB and NZB x NZW Mice

Cited by 34 publications

References 6 publications

What can Sjögren's syndrome-like disease in mice contribute to human Sjögren's syndrome?

What can Sjögren's syndrome-like disease in mice contribute to human Sjögren's syndrome?

Sjögren's syndrome: studying the disease in mice

Sjögren syndrome

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