Eye platelet-rich plasma in the treatment of ocular surface disorders

Alió, Jorge L.; Rodrı́guez, Alejandra; Wróbel-Dudzińska, Dominika

doi:10.1097/icu.0000000000000169

Cited by 72 publications

(70 citation statements)

References 39 publications

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“…Improvement of tear film break-up time and Schirmer tear test results have been observed in the study population [Selek et al, 2000]. Human serum and plasma-derived products such as autologous serum eye drops and autologous platelet-rich plasma (PRP) have been demonstrated to be beneficial in PEDs and dry eye disease [Jeng and Dupps, 2009;Hussain et al, 2014;Alio et al, 2015;Tseng et al, 2015;Soni and Jeng, 2016]. Thus, tretinoin maybe the secondary option for the treatment of SM-induced dry eye.…”

Section: Management Of Delayed Ocular Complications Medical Managementsmentioning

confidence: 94%

“…However, tretinoin did not improve ocular symptoms such as photophobia and foreign body sensation [Selek et al, 2000]. About 50% autologous serum eye drops have been documented to be safe and effective for the management of corneal defects, because the serum composition is similar to the tear, with the presence of epidermal growth factor (EGF) and transforming growth factor-b (TGF-b), leading to regenerative process and healing of corneal defects [Alio et al, 2015;Tseng et al, 2015;Soni and Jeng, 2016]. The efficacy of 0.01% all-transretinoic acid is documented for the treatment of myopia and corneal epithelial erosions [Ubels et al, 1985;Huang et al, 2011].…”

Section: Management Of Delayed Ocular Complications Medical Managementsmentioning

confidence: 99%

“…Human serum and plasma-derived products such as autologous serum eye drops and autologous platelet-rich plasma (PRP) have been demonstrated to be beneficial in PEDs and dry eye disease [Jeng and Dupps, 2009;Hussain et al, 2014;Alio et al, 2015;Tseng et al, 2015;Soni and Jeng, 2016]. About 50% autologous serum eye drops have been documented to be safe and effective for the management of corneal defects, because the serum composition is similar to the tear, with the presence of epidermal growth factor (EGF) and transforming growth factor-b (TGF-b), leading to regenerative process and healing of corneal defects [Alio et al, 2015;Tseng et al, 2015;Soni and Jeng, 2016]. PRP contains more EGF and TGF-b than 50% autologous serum and is showed to be more efficient with a higher cure rate compared to 50% autologous serum in patients with PEDs [Kim et al, 2012].…”

Section: Medical Managementsmentioning

confidence: 99%

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Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Panahi

Rajaee

Sahebkar

2017

J of Cellular Biochemistry

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Sulfur mustard (SM) is a strong blistering, highly reactive, lipophilic chemical war agent that causes injury in different organs including the skin, eyes, and respiratory tract. The Eyes are especially susceptible to the consequences of SM poisoning because of the aqueous and mucosal nature of conjunctiva and cornea. DNA alkylation and depletion of glutathione, are the most important mechanisms of SM action in the eye injuries. Acute clinical symptoms are including decrease in visual acuity, dryness, photophobia, blepharospasm, conjunctivitis, and complaints of foreign body sensation and soreness that gradually progress to severe ocular pain. Corneal abrasions, ulcerations, vesication, and perforations are common corneal consequences in SM injured victims. Appearance of chronic symptoms has been reported as chronic inflammation of the corneal and conjunctival vasculature, ischemia, lipid and cholesterol deposition, scarring in cornea, corneal thinning, opacification and perforation of the cornea, limbal stem cell deficiency (LSCD), and neovascularization. Different medical and surgical protocols have been documented in the management of SM-induced ocular injuries, including preservative-free artificial tears, topical steroids and antibiotic, mydriatic, antiglaucoma drops, therapeutic contact lenses, dark glasses and punctal plugs/cauterization, N-acetylcysteine, tarsorrhaphy, amniotic membrane transplantation, stem cell transplantation, and corneal transplantation. New drugs such as resolvin E1, topical form of essential fatty acids, thymosin β4, 43 amino-acid polypeptides, topical form of curcumin, newly formulated artificial tears, diquafosol, rebamipide, tretinoin, and oral uridineseems to be beneficial in the management of ocular lesion associated with sulfur mustard poisoning. Further studies are needed to approve these drugs in SM victims. J. Cell. Biochem. 118: 3549-3560, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Management Of Delayed Ocular Complications Medical Managementsmentioning

confidence: 94%

Section: Management Of Delayed Ocular Complications Medical Managementsmentioning

confidence: 99%

Section: Medical Managementsmentioning

confidence: 99%

See 1 more Smart Citation

Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Panahi

Rajaee

Sahebkar

2017

J of Cellular Biochemistry

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“…The use of platelet-rich plasma (PRP) has become a strategy in the management of several disorders of the ocular surface, including corneal ulcers3 and persistent ocular epithelial defects 4. PRP has an antiapoptotic effect on corneal stromal cells,5 and autologous platelets have been injected for the management of macular holes 6 7.…”

Section: Introductionmentioning

confidence: 99%

Randomised, prospective clinical trial of platelet-rich plasma injection in the management of severe dry eye

2018

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“…). Since then, the interest in the use of haematological‐derived substances for topical use as a treatment approach for ocular surface disorders has increased significantly in the last years (Alio & Rodriguez ; Anitua & Muruzabal ), with a great variety of studies reported (Tananuvat & Daniell ; Noble & Loh ; Kojima et al. ; Noda‐Tsuruya & Asano‐Kato ; Alio et al.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of treatment of hyposecretory dry eye with platelet‐rich plasma

Garcia-Conca

Abad-Collado²,

Hueso-Abancens

et al. 2018

Acta Ophthalmologica

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Objective: To evaluate and compare the symptomatology and clinical findings in hyposecretory dry eye of the treatment with platelet-rich plasma (PRP) and artificial tears of sodium hyaluronate (SH). Methods: Blind single-centre prospective comparative randomized study including 83 patients with hyposecretory dry eye and mean age of 64.0 years. Two groups were differentiated depending on the treatment applied: 44 patients treated with PRP (PRP group), and 39 patients treated with artificial tears of SH (SH group). Changes in Schimer test, tear osmolarity, corneal and conjunctival staining, tear film break-up time (TF-BUT), conjunctival hyperaemia, dry eye-related symptoms with the Ocular Surface Disease Index questionnaire, and caliciform cell density were evaluated during 30 days of treatment.Results: Significantly larger reduction in symptomatology (p < 0.001), visual improvement (p < 0.001), reduction in hyperaemia (p < 0.001), and corneal and conjunctival staining (p < 0.001), increment of Schirmer test outcome (p ≤ 0.005), and reduction of osmolarity were found in the PRP group in both eyes compared to SH group at 15 and 30 days of treatment. Likewise, a significantly higher increment of caliciform cell density (p < 0.001) was found in the PRP group. Strong and statistically significant correlations were found in the PRP group of the change achieved in visual acuity, hyperaemia, osmolarity, and conjunctival and corneal staining with the baseline values of these variables (p < 0.001). Conclusion: PRP treatment in hyposecretory dry eye induces a more significant positive effect over symptomatology and different dry eye signs than SH, especially in moderate and severe cases.

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Eye platelet-rich plasma in the treatment of ocular surface disorders

Cited by 72 publications

References 39 publications

Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Randomised, prospective clinical trial of platelet-rich plasma injection in the management of severe dry eye

Efficacy and safety of treatment of hyposecretory dry eye with platelet‐rich plasma

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