Background. Eye injuries are one of the most common work-related injuries among certain occupations, including welders. The aim of this study was to determine the prevalence and factors influencing eye injuries among welders in Accra, Ghana. Methods. In a cross-sectional study, we recruited 382 welders in Accra from two welding sites. Systematic sampling was used to select participants. A pretested semistructured questionnaire was used to collect demographic information, history of eye injuries, ownership, and use of eye protective equipment and workplace characteristics. Bivariate and multivariate logistic regressions at 5% level of significance were used to determine factors influencing eye injuries. Data were entered into Microsoft excel and exported to Stata 16/MP for analysis. Results. We found 59.7% of welders engaged in electric/arc welding and 40.3% in gas welding. Overall prevalence of eye injuries was 47.9%, higher among electric/arc welders (73.7%) compared to gas welders (9.7%). Factors associated with eye injuries were engaging in gas welding [AOR: 0.08, 95% CI: 0.04–0.16], higher monthly income [AOR = 5.26; 95% CI: 1.72–16.09], nonuse of eye PPE while working [AOR = 1.86; 95% CI: 1.02–3.43], and no training on the use of eye personal protective equipment [AOR = 2.17; 95% CI: 1.07–4.38]. Conclusion. There is high prevalence of welding-related eye injuries among electric welders. Gas welding, high monthly income, nonuse of eye protective equipment, and inadequate training on the use of eye protective equipment were significantly associated with eye injuries. Health policies should be implemented to ensure all welders use eye personal protective equipment.