Eyelid and conjunctival paracoccidioidomycosis simulating carcinoma

Odashiro, Alexandre Nakao; Odashiro, Patricia R.; Fernandes, P. I.; Leite, Lívio V. O.; Odashiro, Maçanori; Maloney, Shawn C.; Fernandes, Bruno F.; Cesare, Sebastian Di; Burnier, Miguel N.

doi:10.1007/s10792-010-9407-7

Cited by 9 publications

(18 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The incidence of ocular involvement in PCM is very low, and most cases are limited to the eyelid and conjunctiva [6, 8, 11]. Belfort Jr et al described 50 cases of systemic PCM with ocular involvement, among which 38% were eyelid lesions, 12% conjunctival lesions and 4% corneal involvement [6].…”

Section: Discussionmentioning

confidence: 99%

Retinal involvement of Paracoccioidomycosis: A Case Report

et al. 2012

View full text Add to dashboard Cite

Purpose: to describe the clinicopathologic features and treatment of a rare case of systemic paracoccidioidomycosis with choroidal and retinal involvement. Design: retrospective interventional case report. Participant: A 36-year-old young man with visual impairment in left eye with anterior uveitis and presence of whitish perimacular choroidal nodule, multiple underlying whitish spots and mid-periphery exudative retinal detachment. A primary extensive work-up for systemic infectious, autoimmune, neoplasic or inflammatory conditions was performed and high-resolution computer tomography scan demonstrated asymmetric parietal thickening of the trachea and bilateral diffuse multiple lobular opacities. Pulmonary bronchoscopy/biopsy of larynx, trachea and bronchial tube were also performed. Histopathological evaluation showed characteristic of Paracoccidioidomycosis. Intervention: Patient was treated with oral sulphadiazine (1.5 g/day). Main Outcome Measures: Anterior uveitis, retinal examination, histopathological evaluation and primary clinical outcome were observed during systemic treatment. Results: After 3 months of irregular treatment, choroidal lesions decreased in size forming atrophic scars and fibrotic spots; however visual acuity did not show any improvement. Conclusion: We report a rare case of systemic paracoccidioidomycosis with choroidal and retinal involvement treated with oral sulphadiazine.

show abstract

Section: Discussionmentioning

confidence: 99%

Retinal involvement of Paracoccioidomycosis: A Case Report

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The disease progresses slowly with symptoms of cough, expectoration, weight loss, and fever. A characteristic of the chronic form is pulmonary manifestation; however, it can also occur as a multifocal form with fungal spread to more than one organ or tissue such as the oral mucosa, skin, lymph nodes [35][36][37], central nervous system, and gastrointestinal and ocular manifestations [38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Expanding the Clinical and Genetic Spectrum of Human CD40L Deficiency: The Occurrence of Paracoccidioidomycosis and Other Unusual Infections in Brazilian Patients

et al. 2011

View full text Add to dashboard Cite

CD40 ligand (CD40L) deficiency or X-linked hyper-IgM syndrome (X-HIGM) is a well-described primary immunodeficiency in which Pneumocystis jiroveci pneumonia is a common clinical feature. We have identified an unusual high incidence of fungal infections and other not yet described infections in a cohort of 11 X-HIGM patients from nine unrelated Brazilian families. Among these, we describe the first case of paracoccidioidomycosis (PCM) in X-HIGM. The molecular genetic analysis of CD40L was performed by gene sequencing and evaluation of CD40L protein expression. Nine of these 11 patients (82%) had fungal infections. These included fungal species common to CD40L deficiency (P. jiroveci and Candida albicans) as well as Paracoccidioides brasiliensis. One patient presented with PCM at age 11 years and is now doing well at 18 years of age. Additionally, one patient presented with a simultaneous infection with Klebsiella and Acinetobacter, and one with condyloma caused by human papilloma virus. Molecular analysis revealed four previously described CD40L mutations, two novel missense mutations (c.433 T > G and c.476 G > C) resulting in the absence of CD40L protein expression by activated CD4(+) cells and one novel insertion (c.484_485insAA) within the TNFH domain leading to a frame shift and premature stop codon. These observations demonstrated that the susceptibility to fungal infections in X-HIGM extends beyond those typically associated with X-HIGM (P. jiroveci and C. albicans) and that these patients need to be monitored for those pathogens.

show abstract

“…A paracoccidioidomicose foi descrita pela primeira vez no Brasil por Adolf Lutz em 1908 e representa a micose sistêmica mais prevalente em imunocompetentes do Brasil [1][2][3] . Ela é causada por um fungo dimórfico, o Paracoccidioides brasiliensis, o qual à temperatura ambiente adquire a forma de micélio (esporulada) e à 35-37C de levedura, sua forma parasitária, podendo ser encontrada na água, vegetação e solo 1,2,4,5 . A po-pulação de trabalhadores rurais é a mais comumente afetada, sendo que em regiões tropicais e subtropicais a doença é ainda mais prevalente, com destaque para Colômbia, Venezuela, Argentina e Brasil.…”

Section: Introductionunclassified

Lesão palpebral causada por paracoccidioidomicose: relato de caso

Castro¹,

Azevedo²,

Angeloni³

et al. 2022

eOftalmo

View full text Add to dashboard Cite

A paracoccidioidomicose é uma micose sistêmica de grande importância epidemiológica no Brasil e possui grande impacto na população de trabalhadores rurais, principalmente de regiões tropicais e subtropicais. A doença geralmente é transmitida pela inalação de esporos e pode trazer graves manifestações sistêmicas. O acometimento ocular é incomum e as lesões fazem diagnóstico diferencial com uma ampla gama de outras patologias, o que pode dificultar a identificação da doença. O tratamento se dá com antifúngicos sistêmicos, porém a doença possui um caráter recidivante, cursando com fibrose de tecidos acometidos. O presente artigo busca relatar um caso de lesão palpebral por paracoccidioidomicose que foi inicialmente confundido com calázio, cujo diagnóstico correto foi dado posteriormente após biópsia excisional. SUMMARYParacoccidioidomycosis is a systemic mycosis of great epidemiological importance in Brazil and has a significant impact on rural workers, mainly in tropical and subtropical regions. The disease is transmitted via inhalation of spores and can cause severe systemic manifestations. Ocular involvement is uncommon, and the differential diagnosis includes a wide range of other diseases, which can make it difficult to identify the condition. Treatment is with systemic antifungal agents, but the disease has a relapsing course and progresses to fibrosis of the affected tissues. The present study aimed to report a case of eyelid lesion caused by paracoccidioidomycosis that was initially misdiagnosed as chalazion. The correct diagnosis was later confirmed using excisional biopsy.

show abstract

Eyelid and conjunctival paracoccidioidomycosis simulating carcinoma

Cited by 9 publications

References 20 publications

Retinal involvement of Paracoccioidomycosis: A Case Report

Retinal involvement of Paracoccioidomycosis: A Case Report

Expanding the Clinical and Genetic Spectrum of Human CD40L Deficiency: The Occurrence of Paracoccidioidomycosis and Other Unusual Infections in Brazilian Patients

Lesão palpebral causada por paracoccidioidomicose: relato de caso

Contact Info

Product

Resources

About