Eyelid and Periorbital Skin Basal Cell Carcinoma

Mannor, Geva; Chern, Peggy; Barnette, David J.

doi:10.1097/iio.0b013e3181b7ebe8

Cited by 17 publications

(17 citation statements)

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“…(Hilovsky, 1995;Chang et al, 2003;Takamura and Yamashita, 2005;Lin et al, 2006;Coroi et al, 2010) Male dominance was seen in basal cell carcinoma in accordance with previous findings (Frost et al, 1998). Basal cell carcinoma is most common in the lower eyelid, and medial canthal area in the ocular adnexal region (Margo and Waltz, 1993;Allali et al, 2005;Mannor et al, 2009). This tumor generally does not metastasize, however it is locally invasive, and destructive.…”

Section: Discussionsupporting

confidence: 78%

Eyelid Tumors: Clinical Data from an Eye Center in Ankara, Turkey

Gündoğan¹,

Yolcu²,

Taş³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Introduction: The aim of the study was to explore the distribution of eyelid tumors in Ankara, the capital city of Turkey, from a histopathological point of view. Materials and Methods: Medical records of 1,502 patients who had eyelid surgery because of tumoral lesions were retrospectively reviewed after obtaining institutional review board approval. A total of 1,541 lesions with histopathologic diagnosis were included. Inflammatory tumoral lesions were excluded. The lesions were categorized into three groups according to the origin: epidermal, adnexal tumors and 'others', including melanocytic, neural and vascular lesions. Results: Of the total of 1,541, 908 lesions were epidermal in origin. Only 22 (1.5%) were malignant, and 6.0% was premalignant lesions such as actinic keratosis and Bowen's disease. Twenty-one of 22 malignant lesions were basal cell carcinoma. There was only one patient with squamous cell carcinoma and no sebaceous cell carcinoma. Among the benign tumors (92.5%), squamous papilloma was the most frequent (21.8% of all lesions). The other frequent lesions were nevus (17.6%), seborrheic keratosis (17.3%), hydrocystomas (10.6%), xanthelasma (7.6%) and epidermal cysts (7.2%). Conclusions: The results of this study are in accordance with published literature. The absence of sebaceous cell carcinomas needs to be stressed.

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Section: Discussionsupporting

confidence: 78%

Eyelid Tumors: Clinical Data from an Eye Center in Ankara, Turkey

Gündoğan¹,

Yolcu²,

Taş³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Therefore, the type and size of lesion are factors that can influence the outcome of BCC treatment. 4,5 In this study, the authors have evaluated and reported the influence of socio-economic factors on size of periocular BCC on presentation.…”

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confidence: 99%

The Effect of Socio-Economic Status on Severity of Periocular Basal Cell Carcinoma at Presentation

Lim

Agarwal

Young

et al. 2015

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…O tumor periocular é a neoplasia mais comum da prática oftalmológica e, apesar de apenas 15 a 20% das lesões serem malignas, o CBC é responsável por 86 a 95% dos casos (3,6,7) . Em asiáticos, essa porcentagem é inferior, sendo de 30 a 50% das lesões malignas perioculares (8) . Mais frequentemente acomete pacientes entre a sexta e oitava década de vida; porém, até 15% dos casos podem estar presentes em crianças ou adultos jovens (8) .…”

Section: Descriptorsunclassified

“…Em asiáticos, essa porcentagem é inferior, sendo de 30 a 50% das lesões malignas perioculares (8) . Mais frequentemente acomete pacientes entre a sexta e oitava década de vida; porém, até 15% dos casos podem estar presentes em crianças ou adultos jovens (8) .…”

Section: Descriptorsunclassified

“…Quanto à localização das lesões perioculares, de 50 a 60% acometem a pálpebra inferior; de 25 a 30%, o canto medial; 15%, a pálpebra superior, e 5%, o canto lateral. Devido ao seu crescimento lento e indolor, a destruição local é sua principal característica, podendo invadir as vias lacrimais e a órbita (3,6,8) . Embora geralmente não leve à morte, seu diagnóstico tardio torna o tratamento cirúrgico algumas vezes mutilante, trazendo dificuldade para reconstrução da pálpebra e vias lacrimais e, em alguns casos, nem sendo possível preservar o olho (3) .…”

Section: Descriptorsunclassified

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Avaliação da eficácia e segurança da imunoterapia tópica com imiquimode creme 5% no tratamento do carcinoma basocelular nodular periocular

Macedo¹

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Clinical Trials.gov Identifier: NCT00803907 Apoio do CNPq-processo n° 480144/2008-7 ARTIGO ORIGINAL Recebido para publicação em 2/11/2011-Aceito para publicação em 2/3/2011 ABSTRACT Purpose: The objective of this study was to compare the estimated cost of clinical and surgical treatment for basl cell carcinoma of the eyelid. Methods: This was a pilot study of 12 patients with basal cell carcinoma receiving treatment with 5% imiquimod cream at the ocular plastic surgery center, medical school University of São Paulo (HC-FMUSP, Brazil). The cost of clinical treatment was estimated based on the time of treatment and amount of medication consumed by patients in the home setting. The cost of surgical treatment was estimated by ophthalmologists with experience in reconstructive plastic surgery based on analysis of images of the same patients. Surgeons responded to a questionnaire with four questions about surgical technique, surgical materials required, estimated duration of surgery and type of anesthesia.Results: Immunotherapy lasted from 8 to 12 weeks. All patients reported each cold-stored sachet with 5% imiquimod cream lasted 3 days. According to the institution, a box with 12 sachets costs BRL 480.00. Patients required 1.58-3.11 boxes for complete treatment, corresponding to a total cost of BRL 758.40-1,492.80. Based on image analysis, surgeons evaluated surgery would require 1-3 hours. The estimated cost of surgery room and staff was BRL 263.00, to which the cost of supplies was added. Thus, the total cost of surgical treatment was BRL 272.61-864.82. On the average, immunotherapy was 57,64% more costly than surgical treatment. Conclusions: Malignant eyelid tumors are a common finding in clinical ophthalmology. Surgery is still the treatment of choice at our institution, but immunotherapy with 5% imiquimod cream may be indicated for patients with multiple lesions or high surgical risk and for patients declining surgery for reasons of fear or esthetic concerns. The ability to estimate costs related to the treatment of malignant eyelid tumors is an important aid in the financial planning of health care institutions. Further studies should evaluate the possibility of institutions equating the cost of immunotherapy and surgical treatment by acquiring similar but less expensive medications.

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Eyelid and Periorbital Skin Basal Cell Carcinoma

Cited by 17 publications

References 61 publications

Eyelid Tumors: Clinical Data from an Eye Center in Ankara, Turkey

Eyelid Tumors: Clinical Data from an Eye Center in Ankara, Turkey

The Effect of Socio-Economic Status on Severity of Periocular Basal Cell Carcinoma at Presentation

Avaliação da eficácia e segurança da imunoterapia tópica com imiquimode creme 5% no tratamento do carcinoma basocelular nodular periocular

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