Eyelid, conjunctival, and corneal findings in sleep apnea syndrome

Mojon, Daniel S.; Goldblum, David; Fleischhauer, Johannes; Chiou, Auguste G.-Y.; Frueh, Béatrice E.; Heß, Christian; Gugger, Matthias; Bassetti, Claudio L.; Boehnke, Matthias; Mathis, Johannes

doi:10.1016/s0161-6420(99)90256-7

Cited by 111 publications

(114 citation statements)

References 18 publications

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“…Ocular associations reported with OSAHS include floppy eyelid syndrome (FES), blepharoptosis, lower lid ectropion, blepharochalasis, eyelash ptosis, lacrimal gland prolapse, papillary conjunctivitis, filamentary or infectious keratitis, recurrent corneal erosion, keratoconus, optic neuropathy, papilloedema, and glaucoma. [3][4][5][6][7][8][9][10][11][12][13] Specific disease management uses the basic concept of gentle pressurisation of the upper airway during sleep to prevent the collapse of the pharynx. Continuous positive airway pressure (CPAP) administered through a nasal or face mask has remained the mainstay of treatment in OSAHS since its advent in the 1980s.…”

Section: Introductionmentioning

confidence: 99%

Ocular findings in sleep apnoea patients using continuous positive airway pressure

Kadyan

Asghar²,

Dowson

et al. 2009

Eye

107

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Purpose To describe ocular findings in patients with established obstructive sleep apnoea hypopnoea syndrome (OSAHS) using continuous positive airway pressure (CPAP). Methods One hundred and fifteen referrals investigated for OSAHS were included. Patients with OSAHS were compared with those with normal sleep study controls. Subgroup analysis for CPAP users and nonusers was also carried out. Results OSAHS patients (n ¼ 89) compared with the controls (n ¼ 26) had higher ocular irritation symptoms (Po0.001), abnormal tear break-up time (Po0.05) with increased upper (Po0.001) and lower (Po0.001) lid laxity. Floppy eyelid syndrome (FES) was noted in 31.5% (28/89) OSAHS patients vs 3.8% (1/26) controls (P ¼ 0.005). Open angle glaucoma prevalence in OSAHS patients (3/89, 3.4%) was similar to the controls (1/26, 3.8%) (P ¼ 0.92). Sixty-seven (75.3%) OSAHS patients were using CPAP (average duration: 19.6 ± 15.3 months). All CPAP users maintained a supine sleep posture to prevent mask edge leaks. A fifth of CPAP users (14/67) had experienced earlier episodes of conjunctivitis secondary to leaks. CPAP users had similar upper and lower lid laxity (P ¼ 0.746 and 0.633) to non-CPAP users, but a better tear film (P ¼ 0.029) and less ocular irritation (P ¼ 0.134). Conclusion OSAHS patients showed increased ocular irritation, abnormal tear film, lid laxity, and FES. The prevalence of glaucoma in our series was similar to normal population data of 2%, P ¼ 0.429, and may relate to use of CPAP in majority of the patients. More stable tear film in CPAP users was probably secondary to the supine sleep postures necessarily adopted with CPAP use.

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Section: Introductionmentioning

confidence: 99%

Ocular findings in sleep apnoea patients using continuous positive airway pressure

Kadyan

Asghar²,

Dowson

et al. 2009

Eye

107

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“…[1][2][3][4][5][6] Recently, possible ocular manifestations, including optic neuropathy in the form of visual field (VF) defect and disc oedema, normal-tension glaucoma (NTG), pseudotumour cerebri, nonarteritic anterior ischaemic optic neuropathy (NAAION); and anterior segment complications such as floppy eyelid syndrome, upper lid ptosis, lower lid ectropion, blepharochalasis, trichiasis, chronic conjunctivitis, keratoconus, exposure keratopathy, dry eyes, recurrent corneal erosion (RCE), keratitis, and progressive endotheliopathy have aroused ophthalmologists' concern. [7][8][9][10][11][12][13][14][15] However, there are limited evidences in published articles of causal relationship between OSA and the various ocular manifestations, especially in the Chinese locality. Therefore, we designed a prospective case-control study to continuously recruit OSA patients, follow them up to determine the prevalence of ocular manifestations, and observed their progress.…”

Section: Introductionmentioning

confidence: 99%

Moderate to severe obstructive sleep apnoea patients is associated with a higher incidence of visual field defect

Tsang

Chong

et al. 2005

Eye

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Purpose To compare the visual fields (VFs) and optic nerve head changes between obstructive sleep apnoea (OSA) in normotensive patients and an age-matched non-OSA population. Design Case-control study. Participants A total of 41 ethnic Chinese patients diagnosed with moderate to severe OSA referred from the Sleep Laboratory, ENT Department, Tuen Mun Hospital. A total of 35 age-matched non-OSA subjects recruited from the Ophthalmology Department, North District Hospital. Methods Comprehensive ophthalmological and systemic history, complete ophthalmological examination, including central-30 computerized perimetry for all studied patients. Main outcome measures Polysomnographic data, VF indices, optic disc changes Results In the OSA arm, VF indices were significantly subnormal and the incidence of suspicious glaucomatous disc changes was four times higher than that of the control arm. None of the studied patients suffered from any form of anterior segment complications. Conclusions Moderate to severe OSA is associated with a higher incidence of VF defect and glaucomatous optic nerve changes.

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“…10,11,19,20 Bizim hastalarımızın keratometri değerleri normal sınırlar içe-risinde idi ve hiçbirinde keratokonus yoktu. Çalışmamızda keratokonuslu hasta saptanmaması-nın nedeni değerlendirilen OUAS hasta sayısının az olması olabilir.…”

Section: İstati̇sti̇ksel Anali̇zunclassified

“…9 OUAS ile keratokonus arasında da ilişki olduğu bildirilmektedir. 10,11 OUAS toplumda sık görülmesi, önemli göz hastalıkları ile sık birliktelik göstermesi ve bu hastaların geçirebileceği katarakt ve diğer ön segment cerrahileri nedeni ile OUAS'lı olguların ön segment parametrelerinin değerlendirilmesi ve hastalıkla iliş-kili olabilecek ön segment değişikliklerinin ortaya konulması önemlidir. Bu nedenle çalışmamızda, OUAS hastalarının ön segment parametrelerinin kombine Scheimpflug-Placido Disk Sistemi (Sirius, CSO) ile değerlendirilmesi ve normal bireylerle karşılaştırılarak, bu hastalarda görülebilecek ön segment değişimlerinin belirlenmesi amaçlanmıştır.…”

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Evaluation of Anterior Segment Parameters Using Corneal Topography in Obstructive Sleep Apnea Syndrome

Bayhan¹,

Muhafız²,

Bayhan³

et al. 2015

Turkiye Klinikleri J Ophthalmol

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Ö ÖZ ZE ET T A Am ma aç ç: : Obstrüktif uyku apne sendromu (OUAS) olan hastaların ön segment parametrelerinin kornea topografisi ile değerlendirilmesi ve sağlıklı bireyler ile karşılaştırılmasıdır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu prospektif çalışma kapsamında, 45 OUAS hastasının 45 gözü (OUAS grubu) ve 43 sağlıklı bireyin 43 gözü (kontrol grubu) değerlendirilmiştir. Tüm katılımcıların tanısı göğüs hastalıkları kliniği uyku laboratuvarında polisomnografi yapılarak konulmuştur. Hastaların rutin göz muayenelerinin ardından kornea topografisi ile ön segment ölçümleri yapılmıştır. Grupların merkezi kornea kalınlığı (MKK), dik ve düz keratometri değerleri, ön kamara derinliği (ÖKD), ön kamara hacmi (ÖKH), ön kamara açısı (ÖKA), kornea hacmi (KH), görülebilir horizontal iris çapı (GHİÇ) ve horizontal ön kamara çapı (HÖKÇ) verileri karşılaştırılmıştır. B Bu ul lg gu ul la ar r: : Gruplar arasında yaş ve cinsiyet açısından fark yok idi (p>0,05). Ortalama apne hipopne indeksi (AHI) değeri OUAS grubunda 26,78±23,56 iken, kontrol grubunda 3,00±1,64 idi (p<0,001). Gruplar arasında aksiyel uzunluk, göz içi basıncı, refraksiyon değeri ve görme keskinliği açısından anlamlı fark yok idi (p>0,05). MKK OUAS grubunda 529,28±27,63 µm, kontrol grubunda 522,17±34,17 µm idi (p=0,29). Düz ve dik keratometri değerleri OUAS grubunda sırasıyla 43,21±1,71 D ve 43,87±1,74 D, kontrol grubunda aynı sırayla 42,02±1,35 D ve 43,75±1,84 D olarak bulundu (p=0,23 ve p=0,74). Gruplar arasında ÖKA, ÖKD, ÖKH, KH, GHİÇ, HÖKÇ açısından istatistiksel anlamlı fark bulunmadı (p>0,05). S So on nu uç ç: : OUAS'ta ön segment parametrelerinin normal bireylerden farklılık göstermediği saptanmıştır.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Uyku apnesi, tıkayıcı; anterior göz segmenti; kornea topografisi A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To evaluate the anterior segment parameters of obstructive sleep apnea syndrome (OUAS) patients using corneal topography and to compare them with those of healthy individuals. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : 45 eyes of 45 OUAS patients (OUAS group) and 43 eyes of 43 healthy individuals (control group) were evaluated in this prospective study. Diagnostic polysomnography was performed to all subjects in department of chest disease. After routine ophthalmological examination, anterior segment assesment using corneal topography was performed to the control and OUAS groups. Central corneal thickness (CCT), steep and flat keratometry, anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA), corneal volume (CV), horizontal visible iris diameter (HVID) and horizontal anterior chamber diameter (HACD) of groups were compared. R Re es su ul lt ts s: : There was no difference in age and sex between the groups (p>0.05). Mean apnea hypopnea index (AHI) value was 26.78±23.56 in the OUAS group and 3.00±1.64 in the control group (p<0,001). There was no difference in axial length, intraocular pressure, refraction, visual acui...

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Eyelid, conjunctival, and corneal findings in sleep apnea syndrome

Cited by 111 publications

References 18 publications

Ocular findings in sleep apnoea patients using continuous positive airway pressure

Ocular findings in sleep apnoea patients using continuous positive airway pressure

Moderate to severe obstructive sleep apnoea patients is associated with a higher incidence of visual field defect

Evaluation of Anterior Segment Parameters Using Corneal Topography in Obstructive Sleep Apnea Syndrome

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