Eyelid Contracture may Indicate Recurrent Basal Cell Carcinoma, even after Mohs’ Micrographic Surgery

Ong, Lorraine Y.; Lane, Carol

doi:10.1080/01676830802421132

Cited by 8 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ong et al reported progressive eyelid contracture as an early sign of tumor recurrence but emphasized the difficulty in distinguishing it from scar tissue. 17 In our series, clinical examination findings were often nonspecific. Presenting signs of recurrence included contracture, ptosis, and medial canthus erythema.…”

Section: Discussionmentioning

confidence: 61%

Recurrence Following Globe Sparing Excision for Basal Cell Carcinoma with Anterior Orbital Invasion

Tong

Martin

Tumuluri

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

View full text Add to dashboard Cite

Purpose: Globe-sparing excision for periocular basal cell carcinoma (BCC) with orbital invasion has evident benefits, but the ensuing morbidity and characteristics of recurrence are not well elucidated. This study aims to describe the extent of visual morbidity following globe-sparing excision, and the clinicoradiological characteristics of tumor recurrence. Methods: Multicentre retrospective case series. Results: Eight patients were identified for inclusion in this series. Time to recurrence following globe-sparing excision ranged from 3 to 12 years. Seven patients (87.5%) presented with recurrent disease originating from the medial canthus. Clinical features at presentation included contracture (n=4, 50.0%), upper lid ptosis (n=3, 37.5%), a palpable mass (n=2, 25.0%), and hypoesthesia (n=2, 25.0%). Radiologically, tumor recurrence was predominantly characterized by isointense signals on T1 and T2-weighted sequences (n=5, 62.5%) with moderate contrast enhancement. The most common histologic subtype in recurrent tumors was a mixed nodular and infiltrative growth pattern (n=5, 62.5%). Perineural invasion was a feature in four (50%) cases. Salvage therapy in the form of exenteration was performed in seven cases. Vismodegib and adjuvant radiotherapy were provided for one case with surgically unresectable tumor recurrence. Conclusions: Globe-sparing excision for invasive periocular BCC can be complicated by late recurrence that develops rapidly despite silent neuroimaging for years. Early clinical signs are subtle. High-risk features predictive of recurrence include medial canthus location, mixed histological subtypes, and perineural invasion. Patients with such characteristics require lifelong clinical and imaging surveillance following globe-sparing excision.

show abstract

Section: Discussionmentioning

confidence: 61%

Recurrence Following Globe Sparing Excision for Basal Cell Carcinoma with Anterior Orbital Invasion

Tong

Martin

Tumuluri

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

View full text Add to dashboard Cite

show abstract

“…12,16,17 This may be because of the close proximity of these sites to bone and cartilage or incomplete primary treatment. 18 Other risk factors for aggressive BCC are large size, neglected and longstanding tumor, aggressive histologic subtype as discussed previously, and perineural or perivascular invasion. 9, 16 Eyelid contracture has been reported as a clinical indicator of recurrent periocular BCC, even after MMS.…”

Section: Basal Cell Carcinomamentioning

confidence: 91%

“…9,16 Eyelid contracture has been reported as a clinical indicator of recurrent periocular BCC, even after MMS. 18 Other risk factors for aggressive BCC are large size, neglected and longstanding tumor, aggressive histologic subtype as discussed previously, and perineural or perivascular invasion. 12 When evaluating aggressive, high-risk, and neglected BCC, one must also consider the rare possibility of metastasis to the lymph nodes, lungs, and bone (incidence 0.003-0.55%).…”

Section: Basal Cell Carcinomamentioning

confidence: 91%

Periocular Cutaneous Malignancies: A Review of the Literature

Slutsky

Jones

2012

Dermatologic Surgery

105

View full text Add to dashboard Cite

Timely diagnosis and management of periocular malignancies is essential because of their proximity to and potential to invade vital structures such as the orbit, sinuses, and brain. Surgical excision remains the standard of care for the majority of periorbital malignancies, but given the sensitive anatomic location, tissue-sparing techniques with margin control such as Mohs micrographic surgery are the preferred method for most nonmelanoma skin cancers. Depending on tumor type, other treatment modalities may include radiation, chemotherapy, cryosurgery, topical medications, and photodynamic therapy.

show abstract

“…This finding has been reported as a sign of recurrence but not necessarily correlated with orbital invasion. 3 It is a separate entity from postreconstruction contraction. Anecdotally, one of the senior authors (D.S.)…”

Section: To the Editormentioning

confidence: 99%

Medial Canthal Contraction as a Marker for Orbital Invasion in Basal Cell Carcinoma

Juniat¹,

McNab²,

Selva³

2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

View full text Add to dashboard Cite

Eyelid Contracture may Indicate Recurrent Basal Cell Carcinoma, even after Mohs’ Micrographic Surgery

Cited by 8 publications

References 8 publications

Recurrence Following Globe Sparing Excision for Basal Cell Carcinoma with Anterior Orbital Invasion

Recurrence Following Globe Sparing Excision for Basal Cell Carcinoma with Anterior Orbital Invasion

Periocular Cutaneous Malignancies: A Review of the Literature

Medial Canthal Contraction as a Marker for Orbital Invasion in Basal Cell Carcinoma

Contact Info

Product

Resources

About