Eyelid dermatitis due to cocamidopropyl betaine in a hard contact lens solution

Cameli, Norma; Tosti, Giovanni; Venturo, Nicola; Tosti, Antonella

doi:10.1111/j.1600-0536.1991.tb01862.x

Cited by 19 publications

(10 citation statements)

References 12 publications

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“…Contact lens cleaning solutions have been reported to induce allergic contact dermatitis caused by a variety of allergens, such as nickel and cobalt, cocamidopropyl betaine, and myristamidopropyl dimethylamine . No cases of dermatitis caused by PHMB in contact lens cleaning solutions have been published so far.…”

Section: Discussionmentioning

confidence: 99%

“…Further information was then given to the patient regarding trade names and synonyms of PHMB, and she remained disease-free after correctly following our recommendations. of allergens, such as nickel and cobalt, cocamidopropyl betaine, and myristamidopropyl dimethylamine (4)(5)(6). No cases of dermatitis caused by PHMB in contact lens cleaning solutions have been published so far.…”

Section: Case Reportmentioning

confidence: 99%

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Allergic contact dermatitis caused by poly(hexamethylene) biguanide hydrochloride in contact lens care solutions

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Allergic contact dermatitis caused by poly(hexamethylene) biguanide hydrochloride in contact lens care solutions

et al. 2017

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“…It has been recognized for many years that CAPB is an occasional contact allergen (1, 11 -17). Specific cases of allergic contact dermatitis from CAPB have often been associated with a particular product/use of this material, including contact lens cleaners, eye make-up remover and shampoo (13,(18)(19)(20). The last-mentioned use has been implicated as a contributory factor in hand dermatitis experienced by hairdressers (15,21).…”

Section: Discussionmentioning

confidence: 99%

Provocative use tests in CAPB‐allergic subjects with CAPB‐containing product

Fartasch

Diepgen²,

Kuhn³

et al. 1999

Contact Dermatitis

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Cocamidopropyl betaine (CAPB) has been identified as a cause of contact allergy in personal care products. Furthermore, it has been suggested that chemicals responsible are impurities, especially dimethylaminopropylamine (DMAPA). However, skin contact concentrations with these impurities, especially DMAPA, are very low. The aim of the study was to analyse whether subjects with previous positive patch tests to CAPB would react in provocative use tests of a product containing CAPB. 10 individuals with a clinical history of contact allergy to CAPB (by positive patch test and history) took part in a ROAT which used a CAPB-based shower gel at 25% (DMAPA concentration < 1 ppm). None of the subjects showed positive allergic reactions. 1 of the test subjects did experience a flare of atopic dermatitis at the treatment site. Later, all 10 subjects were patch tested to 3 different concentrations of CAPB and DMAPA (0.1%, 0.3%, 1%) to verify the threshold that was capable of inducing a positive test reaction. 5/10 showed clear + reactions to 1% CAPB (typically at D3), whilst a further 3 gave marginal and/or irritant reactions. Only 1 of the subjects showed an allergic reaction to DMAPA. Finally, in uncontrolled use testing with the shower gel, none of the test subjects reported any adverse skin reactions. Thus, the study confirmed that CAPB-sensitive individuals can use a CAPB-based rinse-off product without the risk of experiencing an allergic reaction to CAPB.

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“…For many such products, CAPB is favored over other surfactants because it shows synergistic effects with other surfactants and thus helps to formulate products which are mild to the skin and eyes. On the other hand, concerns about CAPB have been raised recently by several papers reporting allergic contact dermatitis to CAPB in shampoos, skin cleaners, make-up removers, and contact lens solutions (1)(2)(3)(4)(5)(6)(7)(8)(9). Allergic contact dermatitis, sometimes referred to as skin sensitization, is a skin response, such as a rash, resulting from a substance's touching the skin and involving the immune system.…”

mentioning

confidence: 99%

“…Beginning in the early to mid-1980s, a number of case reports and small studies appeared in the literature indicating possible allergic contact dermatitis in individuals exposed to CAPB generally through the use of shampoos, skin cleaners, and other cosmetic-related products either personally or in an occupational setting (1)(2)(3)(4)(5)(6)(7)(8)(9). No systematic study has been undertaken to assess the prevalence of such allergy, but its occurrence is felt to be fairly rare, considering the relatively small number of individuals reported to have experienced reactions to CAPB.…”

mentioning

confidence: 99%

Safety to human skin of cocamidopropyl betaine: A mild surfactant for personal‐care products

Hunter

Fowler²

1998

J Surfact & Detergents

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Cocamidopropyl betaine (CAPB) is a mild surfactant used in shampoos, conditioners, body washes, and other personal‐care products. Several recently published case reports have suggested that CAPB may be a skin sensitizer. A 6‐wk product‐use study was conducted to determine whether subjects with previous positive patch tests to CAPB could use personal‐care products (prototype hair shampoo, liquid handsoap, and body wash) with this surfactant without problems. Post‐study patch testing suggested that amidoamine, a material used in the synthesis of CAPB and a contaminant of CAPB preparations, is a likely sensitizer. However, patch testing did not rule out the possibility that CAPB itself may be an allergen to a small number of presensitized individuals. It is recommended that CAPB with minimal levels of contamination be used for the formulation of personal‐care products.

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Eyelid dermatitis due to cocamidopropyl betaine in a hard contact lens solution

Cited by 19 publications

References 12 publications

Allergic contact dermatitis caused by poly(hexamethylene) biguanide hydrochloride in contact lens care solutions

Allergic contact dermatitis caused by poly(hexamethylene) biguanide hydrochloride in contact lens care solutions

Provocative use tests in CAPB‐allergic subjects with CAPB‐containing product

Safety to human skin of cocamidopropyl betaine: A mild surfactant for personal‐care products

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