Eyelid Juvenile Xanthogranuloma: A Case Report and Literature Review

Hassan, Amirah; Talib, NorLaila; Adzman, Sellymiah; Hussein, Adil

doi:10.7759/cureus.5008

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…The iris is the most frequent anatomical part of the eye that is affected by JXG [12]. To date, eyelid JXG is an uncommon presentation, only with several individual case reports in the literature [12,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

On the knowledge of solitary juvenile xanthogranuloma of the eyelid: a case series and literature review

Chen

Liu

Tang

et al. 2022

Graefes Arch Clin Exp Ophthalmol

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Purpose Solitary eyelid juvenile xanthogranuloma (JXG) is extremely rare, and there is limited literature on its clinical features and treatment outcomes. Here, we present a case series and comprehensive review of the literature on patients with isolated eyelid JXG. Methods We systematically extracted data from our institution’s records of isolated eyelid JXG cases and conducted a search for additional cases from the literature utilising the PubMed, Wanfang, and Chinese National Knowledge Infrastructure (CNKI) databases. Patients with JXG were analysed with respect to age, sex, clinical presentation, therapy, and outcome. Group comparisons were performed. Results Thirty-two patients (including 13 at our institution and 19 from prior publications) were identified. The median age at first presentation was higher in current patients than in the patients from the published cases (median 9 years, range 1.2 to 47.0 years; median 2 years, range 0.5 months to 46.0 years, respectively, P = 0.014). Of the patients who had known characteristics, no significant differences were observed between the two groups in terms of sex, affected eye, eyelid site, type of cutaneous involvement, or duration of symptoms (each P > 0.05). Seventeen (54.8%) patients were male. The most common lesion location was the upper eyelid (n = 10, 62.5%). Twenty-four (75.0%) cutaneous lesions had full-thickness skin involvement; 8 (25.0%) subcutaneous masses had a chalazion-like appearance. Histologically, the JXG masses were characterised by Touton giant cells with inflammatory cells. Additionally, there was no significant difference in treatment modalities between the two groups (P = 0.072), and 24 (75.0%) patients underwent surgical excision. The overall recurrence-free survival was 3.6 to 52.8 (median 27.0) months in the current patients. For published cases with available follow-up information, there was no recurrence in 10 cases and improvement in 1 case, with a median follow-up of 9.5 months. Conclusion Solitary eyelid JXG is a rare clinical entity and should be included in the differential diagnosis of eyelid mass lesions in patients of all age groups. Surgical excision is often selected for efficient treatment and to obtain an excisional biopsy.

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Section: Discussionmentioning

confidence: 99%

On the knowledge of solitary juvenile xanthogranuloma of the eyelid: a case series and literature review

Chen

Liu

Tang

et al. 2022

Graefes Arch Clin Exp Ophthalmol

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Ocular Involvement in the Histiocytoses: A Literature Review with an Illustrative Case Series

Kim

Steeples

Jones

2021

Ocular Immunology and Inflammation

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Epidemiologic Differences and Management of Eyelid Lesions in the Pediatric Population

Sheng¹,

Joshi²,

Williams³

et al. 2022

J Pediatr Ophthalmol Strabismus

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Purpose: To report the relative incidence of excised pediatric eyelid lesions and describe the correlation between the clinical and pathology diagnosis. Methods: This was a retrospective analysis of 137 consecutive pathology-confirmed eyelid lesions excised at a U.S. quaternary children's hospital system. Chalazion was excluded from this study. Results: Benign non-cystic epithelial lesions comprised 48.2% of all excised lesions, followed by mesenchymal (14.6%) and cystic (10.2%) lesions. The most common lesions were molluscum contagiosum (21.9%) and verruca vulgaris (19.0%). Hispanic White race represented 62.0% of cases, followed by non-Hispanic White (23.3%) and Black (8.8%). There were no malignant lesions. A specific preoperative clinical diagnosis was attempted in 70.1% of cases. Of these, 60.4% had a matching histopathology. Conclusions: The authors report a higher proportion of molluscum contagiosum and verruca vulgaris when compared to the literature; these differences may suggest geographic variance, management preference, or a general increase in incidence. Correlation with pathology showed the clinical diagnosis of eyelid lesions can be challenging even for ophthalmologists. However, malignancy in pediatric eyelid lesions is rare and submission for histopathology may be safely omitted, except in cases with atypical features or suspicion for syndromic disease. The decision for surgery should be methodically approached and take into consideration the most likely diagnosis, natural history of the disease, sociopsychological impact, anesthesia risk, and resource burden. [ J Pediatr Ophthalmol Strabismus . 2022;59(6):405–409.]

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Eyelid Juvenile Xanthogranuloma: A Case Report and Literature Review

Cited by 3 publications

References 18 publications

On the knowledge of solitary juvenile xanthogranuloma of the eyelid: a case series and literature review

On the knowledge of solitary juvenile xanthogranuloma of the eyelid: a case series and literature review

Ocular Involvement in the Histiocytoses: A Literature Review with an Illustrative Case Series

Epidemiologic Differences and Management of Eyelid Lesions in the Pediatric Population

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