EZH2 Contributes to Anoikis Resistance and Promotes Epithelial Ovarian Cancer Peritoneal Metastasis by Regulating m6A

Wang, Shaohai; Li, Lin; Bao, K.; Zhang, Yifan; Wang, Wen-wen; Du, Shouying; Jia, Ning; Suo,; Cai, Jing; Guo, Jianfeng; Liu, Gang

doi:10.1007/s11596-023-2719-4

Cited by 6 publications

(1 citation statement)

References 32 publications

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“…In addition, the chemosensitization effect of HDACIs is also related to the combination of drugs. Besides HDACs, other epigenetic enzymes are abnormally expressed in ovarian cancer and participate in ovarian cancer metastasis [154][155][156], which indicates that the combination of HDACIs and inhibitors of these epigenetic enzymes may improve outcomes for patients. In ovarian cancer, many preclinical studies have found that both single-agent HDACIs and the combination of HDACIs with standard chemotherapeutic drugs have significant inhibitory effects on the cell proliferation and metastasis of ovarian cancer [136,157].…”

Section: Discussionmentioning

confidence: 99%

The Roles of Histone Deacetylases in the Regulation of Ovarian Cancer Metastasis

Xu,

Yan,

Wang

et al. 2023

IJMS

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Ovarian cancer is the most lethal gynecologic malignancy, and metastasis is the major cause of death in patients with ovarian cancer, which is regulated by the coordinated interplay of genetic and epigenetic mechanisms. Histone deacetylases (HDACs) are enzymes that can catalyze the deacetylation of histone and some non-histone proteins and that are involved in the regulation of a variety of biological processes via the regulation of gene transcription and the functions of non-histone proteins such as transcription factors and enzymes. Aberrant expressions of HDACs are common in ovarian cancer. Many studies have found that HDACs are involved in regulating a variety of events associated with ovarian cancer metastasis, including cell migration, invasion, and the epithelial–mesenchymal transformation. Herein, we provide a brief overview of ovarian cancer metastasis and the dysregulated expression of HDACs in ovarian cancer. In addition, we discuss the roles of HDACs in the regulation of ovarian cancer metastasis. Finally, we discuss the development of compounds that target HDACs and highlight their importance in the future of ovarian cancer therapy.

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Section: Discussionmentioning

confidence: 99%

The Roles of Histone Deacetylases in the Regulation of Ovarian Cancer Metastasis

Xu,

Yan,

Wang

et al. 2023

IJMS

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Anoikis in cell fate, physiopathology, and therapeutic interventions

Mei,

Jiang,

Tian

et al. 2024

MedComm

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The extracellular matrix (ECM) governs a wide spectrum of cellular fate processes, with a particular emphasis on anoikis, an integrin‐dependent form of cell death. Currently, anoikis is defined as an intrinsic apoptosis. In contrast to traditional apoptosis and necroptosis, integrin correlates ECM signaling with intracellular signaling cascades, describing the full process of anoikis. However, anoikis is frequently overlooked in physiological and pathological processes as well as traditional in vitro research models. In this review, we summarized the role of anoikis in physiological and pathological processes, spanning embryonic development, organ development, tissue repair, inflammatory responses, cardiovascular diseases, tumor metastasis, and so on. Similarly, in the realm of stem cell research focused on the functional evolution of cells, anoikis offers a potential solution to various challenges, including in vitro cell culture models, stem cell therapy, cell transplantation, and engineering applications, which are largely based on the regulation of cell fate by anoikis. More importantly, the regulatory mechanisms of anoikis based on molecular processes and ECM signaling will provide new strategies for therapeutic interventions (drug therapy and cell‐based therapy) in disease. In summary, this review provides a systematic elaboration of anoikis, thus shedding light on its future research.

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The stromal microenvironment endows pancreatic neuroendocrine tumors with spatially specific invasive and metastatic phenotypes

Ye,

Li,

et al. 2024

Cancer Letters

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EZH2 Contributes to Anoikis Resistance and Promotes Epithelial Ovarian Cancer Peritoneal Metastasis by Regulating m6A

Cited by 6 publications

References 32 publications

The Roles of Histone Deacetylases in the Regulation of Ovarian Cancer Metastasis

The Roles of Histone Deacetylases in the Regulation of Ovarian Cancer Metastasis

Anoikis in cell fate, physiopathology, and therapeutic interventions

The stromal microenvironment endows pancreatic neuroendocrine tumors with spatially specific invasive and metastatic phenotypes

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