F-18 fluorodeoxyglucose uptake in leiomyomatous uterus

Shida, Masako; Murakami, Masaru; Tsukada, Hitomi; Ishiguro, Yoshio; Kikuchi, Kei; Yamashita, Eiko; Kajiwara, Hiroshi; Yasuda, Masanori; Ide, Mitsuru

doi:10.1111/j.1525-1438.2006.00778.x

Cited by 26 publications

(16 citation statements)

References 19 publications

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“…In addition, FDG uptake in uterine leiomyoma declines with age [37]. But there are some case reports of intense FDG uptake in large or degenerated benign leiomyomas [36,[38][39][40][41]. Reported high uptake in the leiomyomas might be owing to increased vascularity [40] or large sizes of the tumors [41].…”

Section: Endometrial Uptakementioning

confidence: 91%

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Benign ovarian and endometrial uptake on FDG PET-CT: patterns and pitfalls

Liu

2009

Ann Nucl Med

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Increased ovarian or endometrial uptake may cause a dilemma in the interpretation of whole body F18-fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging or even misdiagnosis of malignant disease. Knowledge of benign FDG uptake of the ovaries and uterus is important for daily practice of nuclear medicine radiologists. Increased uptake in the ovaries or uterus indicates a pathologic or neoplastic process in postmenopausal patients. In premenopausal women, increased ovarian or endometrial uptake can be functional or malignant. Benign functional uptake of premenopausal ovaries or uterus is related to the menstrual cycle; therefore, information about the patient's menstrual status is crucial for interpretation. In addition, correlation with computed tomography (CT), especially diagnostic CT acquired at the same time of PET/CT is very useful in clarifying the location of the uptake and the existence or disappearance of the discrete lesion. Increased ovarian uptake may also be identified in histologically different benign tumor entities. Nonmenstrual-related endometrial uptake may be present in many benign diseases as well.

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Section: Endometrial Uptakementioning

confidence: 91%

“…Therefore, nonmenstrual-related endometrial uptake may represent either benign or malignant process. MRI correlation is usually helpful for differentiation [39,40].…”

Section: Endometrial Uptakementioning

confidence: 99%

Benign ovarian and endometrial uptake on FDG PET-CT: patterns and pitfalls

Liu

2009

Ann Nucl Med

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“…In general, SUV values for leiomyosarcoma were observed to be significantly greater than those for leiomyoma. However, numerous reports for 18-FDG-avid leiomyoma were also identified (36)(37)(38). Furthermore, a series of comprehensive analyses for those patients who underwent 18-FDG-PET/CT revealed that small proportion of benign uterine leiomyomas exhibited positive 18-FDG uptake.…”

Section: Discussionmentioning

confidence: 99%

Benign metastasizing leiomyoma and 18-FDG-PET/CT: A case report and literature review

et al. 2017

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Abstract. Pulmonary benign metastasizing leiomyoma (PBML) is a rare disease entity that usually occurs in females of reproductive age with a previous history of uterine myoma. It is typically characterized by multiple pulmonary tumors consisting of benign leiomyoma cells. In the present study, two cases of PBML are discussed. The patient in each case underwent 2-deoxy-2-(fluorine-18)-fluoro-D-glu cose positron emission tomography/computed tomography (18-FDG-PET/CT) scans. One patient demonstrated a lack of 18-FDG uptake and a quiescent clinical course. However, the second patient exhibited a markedly high uptake of 18-FDG and aggressive cell proliferation. The two tumors revealed significant differences in metabolic behavior and in clinical course; however, they were similar with regard to cellular appearance. A review of previous studies concerning the findings of 18-FDG-PET/CT in published cases of PBML was also conducted and is presented here.

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“…We have already reported on the usefulness of FDG-PET for the diagnosis of uterine sarcomas (7)(8)(9). However, several studies (10,11) have shown positive results for FDG-PET in cases of LM, and its usefulness in the differential diagnosis of LM and LMS is unclear.…”

Section: Introductionmentioning

confidence: 99%

Use of 18F-fluorodeoxyglucose positron emission tomography for diagnosis of uterine sarcomas

Nagamatsu

Umesaki²,

Li³

et al. 2010

Oncol Rep

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Abstract. We evaluated the use of 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) for the diagnosis of uterine sarcomas. FDG-PET combined with serum lactate dehydrogenase (LDH) levels were compared with FDG-PET alone for the diagnosis of leiomyosarcomas (LMS), which are the most difficult uterine sarcomas to diagnose. FDG-PET imaging of endometrial cancer (EC) was used as a reference. Immunoreactivity for glucose transporter-1 (GLUT-I) correlated with FDG uptake was evaluated in sarcomas and leiomyomas (LM), including cases not examined by FDG-PET. FDG was injected after at least 5 h fasting and standardized uptake values (SUVs) were analyzed quantitatively 50-70 min after injection. Immunohistochemical expression of GLUT-1 was studied in paraffin sections of tumors using anti-GLUT-1 antibodies and GLUT-1 expression scores were derived based on staining intensities. FDG-PET was performed preoperatively in a total of 53 patients including 10 with sarcomas, 19 with EC and 24 with LM. Immunohistochemical examination was performed in 17 sarcomas, 6 EC and 9 LM [6 usual LM, 1 uterine smooth muscle tumor of uncertain malignant potential (UMP), and 2 bizarre LM (BLM)]. SUVs for uterine sarcomas and EC were significantly higher (p=0.0001) than those for LMs. There were no significant differences in SUVs among ECs, carcinosarcomas (CS) and LMS. Significant differences in SUVs existed between LM and LMS (p=0.003). However, the diagnostic accuracy for LMS was only 73%. The diagnostic accuracy of FDG-PET combined with serum LDH was 100%. GLUT-1 expression scores were significantly higher in sarcomas and EC than in LM (p<0.0001). Intermediate GLUT-1 scores were found in two of the three cases of UMP and BLM. In conclusion, FDG-PET is useful for diagnosing uterine sarcomas, while FDG-PET combined with serum LDH is useful for diagnosing LMS. Immunohistochemical examination of GLUT-1 confirmed the high FDG uptake in LMS patients.

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F-18 fluorodeoxyglucose uptake in leiomyomatous uterus

Cited by 26 publications

References 19 publications

Benign ovarian and endometrial uptake on FDG PET-CT: patterns and pitfalls

Benign ovarian and endometrial uptake on FDG PET-CT: patterns and pitfalls

Benign metastasizing leiomyoma and 18-FDG-PET/CT: A case report and literature review

Use of 18F-fluorodeoxyglucose positron emission tomography for diagnosis of uterine sarcomas

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