F.23. Polymorphisms of Toll-Like Receptor 2 and 4 Genes in Asthma and COPD

Larocca, N.E.; DeSanctis, Juan; Toro, Félix; Moreno, Dolores

doi:10.1016/j.clim.2006.04.063

Cited by 2 publications

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“…Seventeen studies were excluded because they did not meet the inclusion criteria: eight did not report genotypic frequencies in cases and/or in controls 24 , 25 , 38 , 43 , 44 , 45 , 46 , 47 ; two were cross-sectional studies 48 , 49 ; four were family-based studies, 50 , 51 , 52 , 53 and 3 were abstracts. 54 , 55 , 56 Twenty case-control studies were eligible for meta-analysis, 19 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 one study was in Portuguese, 62 and another was in Chinese. 64 Among the eligible studies, 11 were excluded because the number of studies of the same polymorphism was less than 3.…”

Section: Resultsmentioning

confidence: 99%

Association of Single Nucleotide Polymorphisms in Toll-like Receptor Genes With Asthma Risk: a Systematic Review and Meta-analysis

Tizaoui

Kaabachi

Hamzaoui

et al. 2015

Allergy Asthma Immunol Res

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PurposeAsthma is a complex disease, with contributions from multiple genes, various genetic backgrounds, and environmental factors. Many human epidemiological studies have demonstrated that single nucleotide polymorphisms (SNPs) in Toll-like receptor (TLR) genes are inconsistently associated with asthma risk. Some have demonstrated differences concerning the study design and effect size, and conflicting results have been reported. A meta-analysis is necessary to determine the magnitude of this association.MethodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, a systematic search and meta-analysis of the literature was conducted to estimate the association of SNPs in TLR genes with asthma risk. We screened the medical literature based on the following keyword searches in MEDLINE and EMBASE databases: 'TLR', 'polymorphism', 'asthma', and their combinations.ResultsMeta-analysis of eight studies on TLR4 Asp299Gly showed a marginal association of TLR4 with asthma risk (odds ratio [OR]=0.814 [95% confidence interval [CI], 0.652-1.016; P=0.069]) in the recessive model. TLR4 Thr399Ile was not associated with asthma risk under any genetic model. Meta-analysis of four studies on TLR2 Arg753Gln indicated that TLR2 might be significantly associated with asthma in the dominant and codominant models (P=0.029, P=0.030, and P=0.009, respectively). TLR9 -1237 was marginally associated with asthma risk (OR=0.408 [95% CI, 0.163-1.021; P=0.065]) in the codominant model. Analysis using the allele contrast model showed that the major TLR9 -1237 T allele tended to be a significant protective factor with OR=0.689 (95% CI, 0.471-1.007; P=0.055).ConclusionsThe results showed that TLR4 Asp299Gly, TLR2 Arg753Gln, and TLR9-1237 might contribute significantly to asthma susceptibility. Future genetic association studies would consolidate these findings.

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Section: Resultsmentioning

confidence: 99%

Association of Single Nucleotide Polymorphisms in Toll-like Receptor Genes With Asthma Risk: a Systematic Review and Meta-analysis

Tizaoui

Kaabachi

Hamzaoui

et al. 2015

Allergy Asthma Immunol Res

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“…The characteristics of the selected studies are listed in Table 1 , with a total of 13 studies of 2649 asthma cases and 2542 controls for investigating +896A/G polymorphism and 7 studies of 1443 asthma cases and 1693 controls for +1196C/T polymorphism. As for ethnicity, 11 studies investigated white populations [ 13 , 17 , 19 , 20 , 23 – 28 , 31 ], 2 studies investigated Asian populations [ 16 , 18 ], and 1 study investigated the U.S. population [ 14 ]. Deviation from HWE was detected in the controls of 2 eligible studies [ 13 , 16 ].…”

Section: Resultsmentioning

confidence: 99%

Association of TLR4 (896A/G and 1196C/T) Gene Polymorphisms with Asthma Risk: A Meta-Analysis

Xie

Song

et al. 2015

Med Sci Monit

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BackgroundConflicting data have been reported on the association between Toll-like receptor 4 (TLR4) +896A/G and +1196C/T polymorphisms and the risk of asthma. Therefore, we conducted this meta-analysis to clarify the effect of TLR4 +896A/G and +1196C/T polymorphisms on the risk of asthma.Material/MethodsAn electronic literature search was performed using PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang Data to find relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations. All statistical analyses were conducted using STATA software version 12.0.ResultsA total of 14 studies with 2873 asthma cases and 3110 controls were included. The pooled results indicated a significant association between TLR4 +1196C/T polymorphism and the risk of asthma (T vs. C: OR=0.79, 95%CI=0.63–0.99, P=0.04; TT+CT vs. CC: OR=0.76, 95%CI=0.59–0.96, P=0.03; CT vs. CC: OR=0.74, 95%CI=0.58–0.95, P=0.02). In subgroup analysis by ethnicity, TLR4 +1196C/T polymorphism was significantly associated with asthma risk in Asians (T vs. C: OR=0.73, 95%CI=0.54–0.98, P=0.04; TT+CT vs. CC: OR=0.70, 95%CI=0.51–0.96, P=0.03; CT vs. CC: OR=0.69, 95%CI=0.50–0.96, P=0.03), but not in whites. For TLR4 +896A/G polymorphism, no significant association was found between TLR4 +896A/G polymorphism and asthma risk under any genetic models.ConclusionsThe results of this meta-analysis suggest that T allele of the TLR4 +1196C/T might act as a protective factor against the development of asthma.

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F.23. Polymorphisms of Toll-Like Receptor 2 and 4 Genes in Asthma and COPD

Cited by 2 publications

References 0 publications

Association of Single Nucleotide Polymorphisms in Toll-like Receptor Genes With Asthma Risk: a Systematic Review and Meta-analysis

Association of Single Nucleotide Polymorphisms in Toll-like Receptor Genes With Asthma Risk: a Systematic Review and Meta-analysis

Association of TLR4 (896A/G and 1196C/T) Gene Polymorphisms with Asthma Risk: A Meta-Analysis

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