F-A-S-T: a refocused, intensified, administrative tuberculosis transmission control strategy

Barrera, E.; Livchits, Viktoria; Nardell, Edward A.

doi:10.5588/ijtld.14.0680

Cited by 68 publications

(78 citation statements)

References 11 publications

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“…The "F-A-S-T" strategy, promoted by the World Health Organization for controlling TB transmission, includes finding cases, actively by cough surveillance and rapid molecular sputum testing, separating safely, and treating effectively based on rapid DST [24]. Our study supported that the Xpert MTB/ RIF assay is very helpful in stopping the transmission of TB.…”

Section: Discussionsupporting

confidence: 69%

Real-Life Clinical Practice of Using the Xpert MTB/RIF Assay in Thailand

Kawkitinarong

Suwanpimolkul

Kateruttanakul

et al. 2017

Clinical Infectious Diseases

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Background. Delayed diagnosis of tuberculosis (TB) and drug-resistant TB are major challenges of TB control in Thailand. This study assessed the practicality of the Xpert MTB/RIF assay in a real-life setting with high prevalence of human immunodeficiency virus (HIV) infection and pulmonary tuberculosis (PTB).Methods. This prospective study was conducted at 3 large tertiary care hospitals. Patients who had suspected PTB were enrolled into the study. Expectorated sputum samples were sent for staining, mycobacterial culture, and Xpert MTB/RIF.Results. Four hundred ninety-four patients were enrolled. From 355 cases with final diagnosis of PTB, 263 (71.8%) had definite diagnosis and 92 cases had probable diagnosis. Among TB culture-positive cases, Xpert MTB/RIF had 100% and 81% sensitivity in sputum smear-positive and smear-negative groups, respectively. The specificity was 95.7%. The sensitivity and positive predictive value of Xpert MTB/RIF in culture-negative but clinically diagnosed PTB was 37.8% and 83.8%, respectively. Centrifugation was required in 59% cases with scanty sputum. Five cases were false-positive by Xpert MTB/RIF in patients with nontuberculous mycobacteria, old PTB scar, and immune reconstitution syndrome. Discordant rifampicin susceptibility results of Xpert MTB/RIF and mycobacteria growth indicator tube (MGIT) were confirmed by using rpoB gene sequencing, which raised the sensitivity of Xpert MTB/RIF in detecting rifampicin resistance to 93.8%.Conclusions. Xpert MTB/RIF is an effective tool in diagnosing PTB but will be more cost-effective for sputum-negative patients and in settings with high prevalence of rifampicin resistance. Early diagnosis of TB results in early treatment and implementation of strategies to limit spreading of TB. Sputum centrifugation may increase the yield of Xpert MTB/RIF.

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Section: Discussionsupporting

confidence: 69%

Real-Life Clinical Practice of Using the Xpert MTB/RIF Assay in Thailand

Kawkitinarong

Suwanpimolkul

Kateruttanakul

et al. 2017

Clinical Infectious Diseases

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“…461,462 464 Following the widely publicised and high-mortality outbreak of XDR tuberculosis at the Church of Scotland Hospital in KwaZulu-Natal, South Africa, a series of similar targeted interventions have dramatically reduced transmission in the hospital and in the community.…”

Section: Importance Of Unsuspected Drug Resistancementioning

confidence: 99%

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

Dheda

Gumbo

Maartens

et al. 2017

The Lancet Respiratory Medicine

533

474

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“…A simplified approach to TB IC, known as the F-A-S-T strategy, has been implemented in several other settings. 8 Dedicated TB IC officers or focal points may enhance the implementation of guidelines, the monitoring of supply chains and regular staff screening.…”

Section: Public Health Action the Three I's For Tb-hiv In Nepal 174mentioning

confidence: 99%

Dotting the Three I's for collaborative TB-HIV activities: evaluation of a pilot programme in Kathmandu, Nepal

Sah¹,

Sahu

Lamichhane³

et al. 2016

public health action

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F-A-S-T: a refocused, intensified, administrative tuberculosis transmission control strategy

Cited by 68 publications

References 11 publications

Real-Life Clinical Practice of Using the Xpert MTB/RIF Assay in Thailand

Real-Life Clinical Practice of Using the Xpert MTB/RIF Assay in Thailand

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

Dotting the Three I's for collaborative TB-HIV activities: evaluation of a pilot programme in Kathmandu, Nepal

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