F&lt;sub&gt;1&lt;/sub&gt; Hybrid Animals: Reactivity Against Recognition Structures of Parental Strain Lymphoid Cells

Ramseier, H.; Lindenmann, Jean

doi:10.1159/000162189

Cited by 16 publications

(16 citation statements)

References 10 publications

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“…They mimic the classical experiments of Lafferty and Woolnough (53) in which histoincompatible epithelial thyroid grafts that had lost most or all of their lymphohemopoietic passenger cells were accepted by histoincompatible recipients without inducing an alloresponse. Whether the unresponsiveness to alloantigens on unirradiated thymus grafts and thymocytes is mediated by proper, tolerogenic, alloantigen presentation on lymphohemopoietic antigen-presenting cells alone and/or by some balanced suppressive mechanisms, possibly directed against the host's allorecognition receptors (54,55), remains to be examined not only in the thymus chimeras but also in irradiation bone marrow chimeras.…”

Section: Discussionmentioning

confidence: 99%

Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts.

Zinkernagel¹,

Althage²,

Waterfield³

et al. 1980

The Journal of Experimental Medicine

133

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Congenitally thymusless nude mice that lacked functional T cells were reconstituted with H-2-compatible or -incompatible thymus grafts taken from either fetal, newborn, or adult mice and transplanted under the kidney capsule or subcutaneously. Transplantation with unirradiated fetal (15--17 d) or newborn thymus grafts reconstituted the nude mice as assessed by their subsequent generation of virus-specific cytotoxic T cells in vivo or alloreactive T cells in vitro. The restriction specificity of T cells from homozygous mice was exclusively for the nude host H-2, as shown by direct cytolysis or by cold target competitive inhibition assays. irrespective of whether nude mice were reconstituted with H-2-compatible, semiallogeneic, or H-2-incompatible, unirradiated newborn or fetal thymus grafts (in order of decreasing efficiency of reconstitution). The restriction specificity for the nonhost H-2 of the thymus could not be demonstrated even after primary or secondary sensitization in an infected appropriate F1 environment. These nude mice reconstituted with fetal or newborn grafts were tolerant to the H-2 of the thymus donors. Nude mice transplanted with irradiated adult thymus grafts were reconstituted functionally with syngeneic or semisyngeneic but not with allogeneic thymus grafts. In homozygous nu/nu irradiated heterozygous recipients of F1 thymus grafts, the restriction specificity for the nonhost thymic H-2 could not be elicited upon adoptive sensitization in irradiated and infected F1 heterozygote stimulator mice; in fact, these chimeras' lymphocytes were not tolerant to the nonhost H-2. The discrepancy between the restorative capacity of unirradiated vs. irradiated thymus grafts suggests that precursors of T cells in nude mice can acquire restriction specificity and immunocompetence independently of a conventional, functioning H-2-compatible thymus if exposed to an allogeneic fetal or a newborn thymus that contains functioning thymocytes of donor type but not if reconstituted with an irradiated adult allogeneic thymus.

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Section: Discussionmentioning

confidence: 99%

Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts.

Zinkernagel¹,

Althage²,

Waterfield³

et al. 1980

The Journal of Experimental Medicine

133

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“…Possibly, the recognition structures for this Mis antigen may serve as the antigenic stim ulus for certain C3H X CBA lympho cytes. This thesis is supported by the finding that FI hybrids may produce antibodies against specific recognition structures on parental lymphocytes [7,14,15].…”

Section: Introductionmentioning

confidence: 80%

Search for Specific Effector Functions of C3H × CBA Lymphocytes which Have Proliferated in the Spleens of Irradiated CBA Mice

Lilliehöök

Blomgren

1979

Int Arch Allergy Immunol

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Injection of C3H × CBA hybrid lymphocytes into CBA mice specifically reduces the pool of host T cells which are reactive against the Mls antigen determined by the C3H genome. Since C3H × CBA lymphocytes are triggered to cell division in the spleens of irradiated CBA mice we have now examined if such activated cell populations exhibit any effector functions against CBA lymphocytes which are reactive against C3H-determined antigens. It was observed that such ‘educated’ cell populations were unable to significantly kill CBA lymphocytes which are triggered to cell division in C3H × CBA hosts or CBA lymphocytes which can inhibit proliferation of transplanted C3H × CBA bone marrow cells. Moreover, there was no evidence that such ‘educated’ cell populations can specifically kill anti-C3H-reactive CBA lymphocytes in vitro or damage CBA bone marrow cells in vivo. Thus, these results do not demonstrate that C3H × CBA lymphocytes acquire any effector functions against CBA T cells which are reactive against C3H-determined antigens.

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“…The host produces antibodies against these donor T cell receptors. This anti‐receptor, anti‐idiotypic response is an ‘anti‐antiself’ response 7 and has been observed in parent anti‐F1 immunizations by Ramseier, 8 Ramseier and Lindenmann, 9 and Binz and Wigzell 10 , 11 , 12 and in fully allogeneic immunizations (Hoffmann et al 7…”

Section: Introductionmentioning

confidence: 87%

“…In the Ramseier and Lindenmann study, 9 immunization of (AxB) F1 animals (rats, mice and Syrian hamsters) with lymphoid cells from parent A induced such anti‐anti‐B anti‐idiotypic antibodies in all three species. The anti‐idiotypic antibodies prevented the recognition by parental strain A of the F1 lymphocytes in vitro .…”

Section: Introductionmentioning

confidence: 99%

Second symmetry in the BALB/c‐C57BL/6 (B6) system, and anti‐antiself antibodies in ageing B6 mice

Al-Fahim

Hoffmann

1998

Immunol Cell Biol

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Summary Using an ELISA assay and inhibition of antibody mediated cytotoxicity we found that there was a higher level of anti-antiself activity in B6 anti-BALB/c alloimmune mice than in BALB/c anti-B6 mice. In contrast, when an inhibition of cellular cytotoxicity assay was used to assay for the activity, similar levels of antiantiself antibodies were seen in B6 anti-BALB/c and BALB/c anti-B6 sera. Anti-antiself antibodies in alloimmune sera are not absorbed by the cellular immunogen as readily as are anti-foreign antibodies. These results are interpreted in terms of anti-antiself antibodies being directed mainly against T cell receptors speci®c for self. Antiantiself antibodies are found also in old B6 mice, that are also known to make autoantibodies.

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F<sub>1</sub> Hybrid Animals: Reactivity Against Recognition Structures of Parental Strain Lymphoid Cells

Cited by 16 publications

References 10 publications

Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts.

Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts.

Search for Specific Effector Functions of C3H × CBA Lymphocytes which Have Proliferated in the Spleens of Irradiated CBA Mice

Second symmetry in the BALB/c‐C57BL/6 (B6) system, and anti‐antiself antibodies in ageing B6 mice

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