2001
DOI: 10.1073/pnas.081062398
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F-spondin is a contact-repellent molecule for embryonic motor neurons

Abstract: The floor plate plays a key role in patterning axonal trajectory in the embryonic spinal cord by providing both long-range and local guidance cues that promote or inhibit axonal growth toward and across the ventral midline of the spinal cord, thus acting as an intermediate target for a number of crossing (commissural) and noncrossing (motor) axons. F-spondin, a secreted adhesion molecule expressed in the embryonic floor plate and the caudal somite of birds, plays a dual role in patterning the nervous system. I… Show more

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Cited by 52 publications
(58 citation statements)
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References 35 publications
(61 reference statements)
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“…SPON1 encodes the developmentally regulated protein Fspondin, which is induced in neuronal injury and impairs the binding of cells to the ECM (9). In rats, this protein induces a hippocampal progenitor cell line (and primary cortical neural cells) to differentiate into cells with neuronal features (10).…”
Section: Resultsmentioning
confidence: 99%
“…SPON1 encodes the developmentally regulated protein Fspondin, which is induced in neuronal injury and impairs the binding of cells to the ECM (9). In rats, this protein induces a hippocampal progenitor cell line (and primary cortical neural cells) to differentiate into cells with neuronal features (10).…”
Section: Resultsmentioning
confidence: 99%
“…Considering the strong relationships that exist between PRV and the axons [11], this is no more surprising than the result for neurogenesis. The case of the SPON2 gene involved in nerve system patterning [40] referenced on 01/13/2004, by Gene Ontology under the terms described in this article (axon guidance, extracellular matrix) is of particular interest. A recent report [18] strongly suggests that SPON2 is also involved in defense mechanisms and could be essential to initiation of the innate immune response.…”
Section: Discussionmentioning
confidence: 99%
“…5a and Supplement Data 1). Spondin proteins are known to be glycosylated and to be a component of the extracellular matrix (ECM) environment, which may enable multicellularity in metazoans through cell adhesion, and have been found to help coordinate nerve cell development through adhesion and repulsion (Michel et al, 2010;Tzarfati-Majar et al, 2011). Despite this large variation in protein abundance, the function of spondins in eukaryotic phytoplankton, including Phaeocystis, remains largely unknown.…”
Section: Observation Of An Iron-induced Switch From Single Cells To Cmentioning
confidence: 99%