F1 fraction isolated from Mesobuthus eupeus scorpion venom induces macrophage polarization toward M1 phenotype and exerts anti-tumoral effects on the CT26 tumor cell line

Sadeghi, Mahvash; Amari, Afshin; Asadirad, Ali; Nemati, Mohammad; Khodadadi, Ali

doi:10.1016/j.intimp.2024.111960

International Immunopharmacology

2024

DOI: 10.1016/j.intimp.2024.111960

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F1 fraction isolated from Mesobuthus eupeus scorpion venom induces macrophage polarization toward M1 phenotype and exerts anti-tumoral effects on the CT26 tumor cell line

Mahvash Sadeghi,

Afshin Amari,

Ali Asadirad

et al.

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Inosine Prevents Colorectal Cancer Progression by Inducing M1 Phenotypic Polarization of Macrophages

Ma,

Qian,

et al. 2024

Molecules

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Inosine (IS) is a naturally occurring metabolite of adenosine with potent immunomodulatory effects. This study investigates the immunomodulatory effects of inosine, particularly its ability to inhibit the development of colorectal cancer (CRC) cells CT26 through modulation of macrophage phenotypes. Aside from the already reported effects of inosine on T cells, in this study, in vitro experiments revealed that inosine could modulate macrophage phenotype. The effects of inosine on the M1/M2 macrophage polarization were investigated at the cellular level. Its role in regulating CRC proliferation and migration was further examined. In addition, a CT26 tumor mouse model was established to assess the mechanism of action of inosine by tumor weight measurement, immunohistochemistry, and immunofluorescence. Inosine significantly increased M1 macrophage markers CD86 and iNOS and enhanced the anti-tumor activity of M1 macrophages, effectively inhibiting CRC progression and metastasis potential. In vivo, inosine had significant tumor inhibitory activity. It also significantly reduced the expression of Ki-67 and promoted the polarization of M1 macrophages.

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Inosine Prevents Colorectal Cancer Progression by Inducing M1 Phenotypic Polarization of Macrophages

Ma,

Qian,

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

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F1 fraction isolated from Mesobuthus eupeus scorpion venom induces macrophage polarization toward M1 phenotype and exerts anti-tumoral effects on the CT26 tumor cell line

Cited by 1 publication

References 39 publications

Inosine Prevents Colorectal Cancer Progression by Inducing M1 Phenotypic Polarization of Macrophages

Inosine Prevents Colorectal Cancer Progression by Inducing M1 Phenotypic Polarization of Macrophages

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